Causal Relationship Between Colorectal Cancer and Common Psychiatric Disorders: A Two-sample Mendelian Randomization Study
ObjectiveTo elucidate the causal relationships between colorectal cancer (CRC) and prevalent psychiatric disorders through a two-sample Mendelian randomization approach. MethodsUtilizing publicly available genome-wide association study data, we explored the connections between CRC and various psychi...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
Magazine House of Cancer Research on Prevention and Treatment
2025-06-01
|
| Series: | Zhongliu Fangzhi Yanjiu |
| Subjects: | |
| Online Access: | http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2025.24.1154 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849418609674158080 |
|---|---|
| author | Yuan YAO Mingze YANG Chen LI Haibo CHENG |
| author_facet | Yuan YAO Mingze YANG Chen LI Haibo CHENG |
| author_sort | Yuan YAO |
| collection | DOAJ |
| description | ObjectiveTo elucidate the causal relationships between colorectal cancer (CRC) and prevalent psychiatric disorders through a two-sample Mendelian randomization approach. MethodsUtilizing publicly available genome-wide association study data, we explored the connections between CRC and various psychiatric disorders, including depression, anxiety, bipolar disorder, and schizophrenia. We applied three statistical analyses: inverse variance weighting, MR-Egger, and median weighting. Sensitivity analyses were conducted to ensure the reliability and validity of the results. ResultsInverse variance weighting analysis showed no significant links between CRC and depression (P=0.090), anxiety (P=0.099), or schizophrenia (P=0.899). Conversely, a significant inverse relationship was found with bipolar disorder (P=0.010). ConclusionNo causal connection exists between CRC and the psychiatric conditions of depression, anxiety, or schizophrenia. However, CRC may have a causal association with a reduced risk of bipolar disorder, further supporting the existence of the gut-brain axis. |
| format | Article |
| id | doaj-art-4850765d91694d2287f02cb58b92b5ce |
| institution | Kabale University |
| issn | 1000-8578 |
| language | zho |
| publishDate | 2025-06-01 |
| publisher | Magazine House of Cancer Research on Prevention and Treatment |
| record_format | Article |
| series | Zhongliu Fangzhi Yanjiu |
| spelling | doaj-art-4850765d91694d2287f02cb58b92b5ce2025-08-20T03:32:24ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85782025-06-0152649650110.3971/j.issn.1000-8578.2025.24.115420241154Causal Relationship Between Colorectal Cancer and Common Psychiatric Disorders: A Two-sample Mendelian Randomization StudyYuan YAO0Mingze YANG1Chen LI2Haibo CHENG3The First School of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaThe First School of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaThe First School of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaThe First School of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaObjectiveTo elucidate the causal relationships between colorectal cancer (CRC) and prevalent psychiatric disorders through a two-sample Mendelian randomization approach. MethodsUtilizing publicly available genome-wide association study data, we explored the connections between CRC and various psychiatric disorders, including depression, anxiety, bipolar disorder, and schizophrenia. We applied three statistical analyses: inverse variance weighting, MR-Egger, and median weighting. Sensitivity analyses were conducted to ensure the reliability and validity of the results. ResultsInverse variance weighting analysis showed no significant links between CRC and depression (P=0.090), anxiety (P=0.099), or schizophrenia (P=0.899). Conversely, a significant inverse relationship was found with bipolar disorder (P=0.010). ConclusionNo causal connection exists between CRC and the psychiatric conditions of depression, anxiety, or schizophrenia. However, CRC may have a causal association with a reduced risk of bipolar disorder, further supporting the existence of the gut-brain axis.http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2025.24.1154colorectal cancerdepressionanxietybipolar disorderschizophreniamendelian randomizationgut-brain axis |
| spellingShingle | Yuan YAO Mingze YANG Chen LI Haibo CHENG Causal Relationship Between Colorectal Cancer and Common Psychiatric Disorders: A Two-sample Mendelian Randomization Study Zhongliu Fangzhi Yanjiu colorectal cancer depression anxiety bipolar disorder schizophrenia mendelian randomization gut-brain axis |
| title | Causal Relationship Between Colorectal Cancer and Common Psychiatric Disorders: A Two-sample Mendelian Randomization Study |
| title_full | Causal Relationship Between Colorectal Cancer and Common Psychiatric Disorders: A Two-sample Mendelian Randomization Study |
| title_fullStr | Causal Relationship Between Colorectal Cancer and Common Psychiatric Disorders: A Two-sample Mendelian Randomization Study |
| title_full_unstemmed | Causal Relationship Between Colorectal Cancer and Common Psychiatric Disorders: A Two-sample Mendelian Randomization Study |
| title_short | Causal Relationship Between Colorectal Cancer and Common Psychiatric Disorders: A Two-sample Mendelian Randomization Study |
| title_sort | causal relationship between colorectal cancer and common psychiatric disorders a two sample mendelian randomization study |
| topic | colorectal cancer depression anxiety bipolar disorder schizophrenia mendelian randomization gut-brain axis |
| url | http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2025.24.1154 |
| work_keys_str_mv | AT yuanyao causalrelationshipbetweencolorectalcancerandcommonpsychiatricdisordersatwosamplemendelianrandomizationstudy AT mingzeyang causalrelationshipbetweencolorectalcancerandcommonpsychiatricdisordersatwosamplemendelianrandomizationstudy AT chenli causalrelationshipbetweencolorectalcancerandcommonpsychiatricdisordersatwosamplemendelianrandomizationstudy AT haibocheng causalrelationshipbetweencolorectalcancerandcommonpsychiatricdisordersatwosamplemendelianrandomizationstudy |