Personalized medicine in pancreatic cancer: Harnessing the potential of mRNA vaccines
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer with a five-year survival rate of just 7%. Its late diagnosis and limited treatment options contribute to poor outcomes. Immunotherapy has had little success due to PDAC’s dense and immunosuppressive tumor environment. Emerging mRNA v...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Journal of Genetic Engineering and Biotechnology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1687157X25000137 |
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| author | Aariz Hussain Areeba Fareed |
| author_facet | Aariz Hussain Areeba Fareed |
| author_sort | Aariz Hussain |
| collection | DOAJ |
| description | Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer with a five-year survival rate of just 7%. Its late diagnosis and limited treatment options contribute to poor outcomes. Immunotherapy has had little success due to PDAC’s dense and immunosuppressive tumor environment. Emerging mRNA vaccines, such as autogene cevumeran (BNT122), show promise in enhancing treatment. Preliminary trials have reported prolonged survival with minimal side effects. Despite this progress, the complexity of PDAC remains a significant challenge. Continued research is essential to fully realize the potential of mRNA-based therapies in combating this deadly cancer. |
| format | Article |
| id | doaj-art-485045b7ff4c43479a77af48e8db7a7d |
| institution | DOAJ |
| issn | 1687-157X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Genetic Engineering and Biotechnology |
| spelling | doaj-art-485045b7ff4c43479a77af48e8db7a7d2025-08-20T02:47:36ZengElsevierJournal of Genetic Engineering and Biotechnology1687-157X2025-03-0123110046910.1016/j.jgeb.2025.100469Personalized medicine in pancreatic cancer: Harnessing the potential of mRNA vaccinesAariz Hussain0Areeba Fareed1Corresponding author.; Karachi Medical and Dental College, PakistanKarachi Medical and Dental College, PakistanPancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer with a five-year survival rate of just 7%. Its late diagnosis and limited treatment options contribute to poor outcomes. Immunotherapy has had little success due to PDAC’s dense and immunosuppressive tumor environment. Emerging mRNA vaccines, such as autogene cevumeran (BNT122), show promise in enhancing treatment. Preliminary trials have reported prolonged survival with minimal side effects. Despite this progress, the complexity of PDAC remains a significant challenge. Continued research is essential to fully realize the potential of mRNA-based therapies in combating this deadly cancer.http://www.sciencedirect.com/science/article/pii/S1687157X25000137Pancreatic cancermRNA vaccinesTreatmentChemotherapySurgeryPersonalized Medicine |
| spellingShingle | Aariz Hussain Areeba Fareed Personalized medicine in pancreatic cancer: Harnessing the potential of mRNA vaccines Journal of Genetic Engineering and Biotechnology Pancreatic cancer mRNA vaccines Treatment Chemotherapy Surgery Personalized Medicine |
| title | Personalized medicine in pancreatic cancer: Harnessing the potential of mRNA vaccines |
| title_full | Personalized medicine in pancreatic cancer: Harnessing the potential of mRNA vaccines |
| title_fullStr | Personalized medicine in pancreatic cancer: Harnessing the potential of mRNA vaccines |
| title_full_unstemmed | Personalized medicine in pancreatic cancer: Harnessing the potential of mRNA vaccines |
| title_short | Personalized medicine in pancreatic cancer: Harnessing the potential of mRNA vaccines |
| title_sort | personalized medicine in pancreatic cancer harnessing the potential of mrna vaccines |
| topic | Pancreatic cancer mRNA vaccines Treatment Chemotherapy Surgery Personalized Medicine |
| url | http://www.sciencedirect.com/science/article/pii/S1687157X25000137 |
| work_keys_str_mv | AT aarizhussain personalizedmedicineinpancreaticcancerharnessingthepotentialofmrnavaccines AT areebafareed personalizedmedicineinpancreaticcancerharnessingthepotentialofmrnavaccines |