Assessment of serum parameters caused by the outbreak of mycoplasma pneumoniae pneumonia in children after COVID-19
Abstract Mycoplasma pneumonia pneumonia(MPP) is a common respiratory disease that often occurs in children. The purpose of this study was to explore the clinical characteristics of children with mycoplasma pneumoniae pneumonia, the first outbreak after the prevalence of COVID-19 epidemic. Meanwhile,...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-08-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-13555-6 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849763323608825856 |
|---|---|
| author | Fangye Zhou Sen Yang Wenchang Zhang Min Huang |
| author_facet | Fangye Zhou Sen Yang Wenchang Zhang Min Huang |
| author_sort | Fangye Zhou |
| collection | DOAJ |
| description | Abstract Mycoplasma pneumonia pneumonia(MPP) is a common respiratory disease that often occurs in children. The purpose of this study was to explore the clinical characteristics of children with mycoplasma pneumoniae pneumonia, the first outbreak after the prevalence of COVID-19 epidemic. Meanwhile, this study also analyzed the predictive value of serum protein indicators and coagulation parameters in the MPP group, as well as the correlation between these indicators. Children with Mycoplasma pneumoniae admitted to the pediatric ward of Chengdu Fifth People’s Hospital from May 2023 to March 2024 were selected. After screening, 411 children who met the research criteria were selected as the study subjects. All of the blood samples were tested for coagulation function, procalcitonin, serum protein and glucose among MPP group and control group. All data were processed for statistical analysis using GraphPad Prism 10.2.3. Comparison of the serum proteins and coagulation function between the MPP group and control group showed that prothrobin time(PT), thrombin time (TT), fibrinogen(Fbg), activated partial thromboplastin time (APTT), international normalized ration(INR), D-Dimer(DD) were significantly higher(P < 0.05) in MPP group. Total protein, albumin, prealbumin, alkaline phosphatase, lactate dehydrogenase, adanosine deaminase, glucose, platelet, procalcitonin also were significantly higher(P < 0.05) in MPP group. A multiple logistic regression analysis showed that the children in MPP group were a statistically significant difference in comparison of TT, Fbg, total protein, albumin, glucose, platelet expression in predicting the development. Then we analyzed the area under the ROC curve and correlation of serum parameters with significant differences in MPP group children. These results indicate that the coagulation function and serum protein of MPP patients who first broke out after the COVID-19 epidemic are different from the previous clinical characteristics, which can be used as a reference for auxiliary diagnosis. |
| format | Article |
| id | doaj-art-484fd45986ce4ddbae76dcc8bd5cb712 |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-484fd45986ce4ddbae76dcc8bd5cb7122025-08-20T03:05:26ZengNature PortfolioScientific Reports2045-23222025-08-011511610.1038/s41598-025-13555-6Assessment of serum parameters caused by the outbreak of mycoplasma pneumoniae pneumonia in children after COVID-19Fangye Zhou0Sen Yang1Wenchang Zhang2Min Huang3Chengdu Fifth People’s Hospital, Chengdu University of T.C.MChengdu Fifth People’s Hospital, Chengdu University of T.C.MChengdu Fifth People’s Hospital, Chengdu University of T.C.MChengdu Fifth People’s Hospital, Chengdu University of T.C.MAbstract Mycoplasma pneumonia pneumonia(MPP) is a common respiratory disease that often occurs in children. The purpose of this study was to explore the clinical characteristics of children with mycoplasma pneumoniae pneumonia, the first outbreak after the prevalence of COVID-19 epidemic. Meanwhile, this study also analyzed the predictive value of serum protein indicators and coagulation parameters in the MPP group, as well as the correlation between these indicators. Children with Mycoplasma pneumoniae admitted to the pediatric ward of Chengdu Fifth People’s Hospital from May 2023 to March 2024 were selected. After screening, 411 children who met the research criteria were selected as the study subjects. All of the blood samples were tested for coagulation function, procalcitonin, serum protein and glucose among MPP group and control group. All data were processed for statistical analysis using GraphPad Prism 10.2.3. Comparison of the serum proteins and coagulation function between the MPP group and control group showed that prothrobin time(PT), thrombin time (TT), fibrinogen(Fbg), activated partial thromboplastin time (APTT), international normalized ration(INR), D-Dimer(DD) were significantly higher(P < 0.05) in MPP group. Total protein, albumin, prealbumin, alkaline phosphatase, lactate dehydrogenase, adanosine deaminase, glucose, platelet, procalcitonin also were significantly higher(P < 0.05) in MPP group. A multiple logistic regression analysis showed that the children in MPP group were a statistically significant difference in comparison of TT, Fbg, total protein, albumin, glucose, platelet expression in predicting the development. Then we analyzed the area under the ROC curve and correlation of serum parameters with significant differences in MPP group children. These results indicate that the coagulation function and serum protein of MPP patients who first broke out after the COVID-19 epidemic are different from the previous clinical characteristics, which can be used as a reference for auxiliary diagnosis.https://doi.org/10.1038/s41598-025-13555-6Mycoplasma pneumonia pneumoniaCoagulation functionSerum proteins |
| spellingShingle | Fangye Zhou Sen Yang Wenchang Zhang Min Huang Assessment of serum parameters caused by the outbreak of mycoplasma pneumoniae pneumonia in children after COVID-19 Scientific Reports Mycoplasma pneumonia pneumonia Coagulation function Serum proteins |
| title | Assessment of serum parameters caused by the outbreak of mycoplasma pneumoniae pneumonia in children after COVID-19 |
| title_full | Assessment of serum parameters caused by the outbreak of mycoplasma pneumoniae pneumonia in children after COVID-19 |
| title_fullStr | Assessment of serum parameters caused by the outbreak of mycoplasma pneumoniae pneumonia in children after COVID-19 |
| title_full_unstemmed | Assessment of serum parameters caused by the outbreak of mycoplasma pneumoniae pneumonia in children after COVID-19 |
| title_short | Assessment of serum parameters caused by the outbreak of mycoplasma pneumoniae pneumonia in children after COVID-19 |
| title_sort | assessment of serum parameters caused by the outbreak of mycoplasma pneumoniae pneumonia in children after covid 19 |
| topic | Mycoplasma pneumonia pneumonia Coagulation function Serum proteins |
| url | https://doi.org/10.1038/s41598-025-13555-6 |
| work_keys_str_mv | AT fangyezhou assessmentofserumparameterscausedbytheoutbreakofmycoplasmapneumoniaepneumoniainchildrenaftercovid19 AT senyang assessmentofserumparameterscausedbytheoutbreakofmycoplasmapneumoniaepneumoniainchildrenaftercovid19 AT wenchangzhang assessmentofserumparameterscausedbytheoutbreakofmycoplasmapneumoniaepneumoniainchildrenaftercovid19 AT minhuang assessmentofserumparameterscausedbytheoutbreakofmycoplasmapneumoniaepneumoniainchildrenaftercovid19 |