Paneth cells as the cornerstones of intestinal and organismal health: a primer
Abstract Paneth cells are versatile secretory cells located in the crypts of Lieberkühn of the small intestine. In normal conditions, they function as the cornerstones of intestinal health by preserving homeostasis. They perform this function by providing niche factors to the intestinal stem cell co...
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| Format: | Article |
| Language: | English |
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Springer Nature
2022-12-01
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| Series: | EMBO Molecular Medicine |
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| Online Access: | https://doi.org/10.15252/emmm.202216427 |
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| _version_ | 1849226058657693696 |
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| author | Charlotte Wallaeys Natalia Garcia‐Gonzalez Claude Libert |
| author_facet | Charlotte Wallaeys Natalia Garcia‐Gonzalez Claude Libert |
| author_sort | Charlotte Wallaeys |
| collection | DOAJ |
| description | Abstract Paneth cells are versatile secretory cells located in the crypts of Lieberkühn of the small intestine. In normal conditions, they function as the cornerstones of intestinal health by preserving homeostasis. They perform this function by providing niche factors to the intestinal stem cell compartment, regulating the composition of the microbiome through the production and secretion of antimicrobial peptides, performing phagocytosis and efferocytosis, taking up heavy metals, and preserving barrier integrity. Disturbances in one or more of these functions can lead to intestinal as well as systemic inflammatory and infectious diseases. This review discusses the multiple functions of Paneth cells, and the mechanisms and consequences of Paneth cell dysfunction. It also provides an overview of the tools available for studying Paneth cells. |
| format | Article |
| id | doaj-art-4841a5af76f84da8a2601b3f98ea63b4 |
| institution | Kabale University |
| issn | 1757-4676 1757-4684 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | EMBO Molecular Medicine |
| spelling | doaj-art-4841a5af76f84da8a2601b3f98ea63b42025-08-24T11:43:43ZengSpringer NatureEMBO Molecular Medicine1757-46761757-46842022-12-0115212610.15252/emmm.202216427Paneth cells as the cornerstones of intestinal and organismal health: a primerCharlotte Wallaeys0Natalia Garcia‐Gonzalez1Claude Libert2Center for Inflammation Research‐VIBCenter for Inflammation Research‐VIBCenter for Inflammation Research‐VIBAbstract Paneth cells are versatile secretory cells located in the crypts of Lieberkühn of the small intestine. In normal conditions, they function as the cornerstones of intestinal health by preserving homeostasis. They perform this function by providing niche factors to the intestinal stem cell compartment, regulating the composition of the microbiome through the production and secretion of antimicrobial peptides, performing phagocytosis and efferocytosis, taking up heavy metals, and preserving barrier integrity. Disturbances in one or more of these functions can lead to intestinal as well as systemic inflammatory and infectious diseases. This review discusses the multiple functions of Paneth cells, and the mechanisms and consequences of Paneth cell dysfunction. It also provides an overview of the tools available for studying Paneth cells.https://doi.org/10.15252/emmm.202216427paneth cellsgut homeostasisinfectionantimicrobial peptides |
| spellingShingle | Charlotte Wallaeys Natalia Garcia‐Gonzalez Claude Libert Paneth cells as the cornerstones of intestinal and organismal health: a primer EMBO Molecular Medicine paneth cells gut homeostasis infection antimicrobial peptides |
| title | Paneth cells as the cornerstones of intestinal and organismal health: a primer |
| title_full | Paneth cells as the cornerstones of intestinal and organismal health: a primer |
| title_fullStr | Paneth cells as the cornerstones of intestinal and organismal health: a primer |
| title_full_unstemmed | Paneth cells as the cornerstones of intestinal and organismal health: a primer |
| title_short | Paneth cells as the cornerstones of intestinal and organismal health: a primer |
| title_sort | paneth cells as the cornerstones of intestinal and organismal health a primer |
| topic | paneth cells gut homeostasis infection antimicrobial peptides |
| url | https://doi.org/10.15252/emmm.202216427 |
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