Caffeine enhances antitumor T-cell activity by suppressing kynurenine pathway in colorectal cancer

Caffeine enhances antitumor T-cell activity by suppressing kynurenine pathway in colorectal cancer

Abstract Colorectal cancer (CRC) is a leading global health issue, ranking third in incidence and second in cancer mortality. Immunotherapy, effective mainly in mismatch repair-deficient CRC, may benefit from dietary interventions. This study investigates caffeine’s potential to boost programmed dea...

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Bibliographic Details
Main Authors: Yuechen Liu, Zhengyu Liu, Yating Hu, Yunyan Ling, Shunjie Qing, Yang Liu, Yizhi Zhan, Zhiyong Shen, Yuan Fang, Haijun Deng
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60958-0
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