Hepatic transcript profiling in beef cattle: Effects of rumen-protected niacin supplementation.
The objective of our study was to assess the effect of rumen-protected niacin supplementation on the transcriptome of liver tissue in growing Angus × Simmental steers and heifers through RNA-seq analysis. Consequently, we wanted to assess the known role of niacin in the physiological processes of va...
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Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0289409&type=printable |
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| author | Gastón F Alfaro Valentino Palombo Mariasilvia D'Andrea Wenqi Cao Yue Zhang Jonathan Beever Russell B Muntifering Wilmer J Pacheco Soren P Rodning Xu Wang Sonia J Moisá |
| author_facet | Gastón F Alfaro Valentino Palombo Mariasilvia D'Andrea Wenqi Cao Yue Zhang Jonathan Beever Russell B Muntifering Wilmer J Pacheco Soren P Rodning Xu Wang Sonia J Moisá |
| author_sort | Gastón F Alfaro |
| collection | DOAJ |
| description | The objective of our study was to assess the effect of rumen-protected niacin supplementation on the transcriptome of liver tissue in growing Angus × Simmental steers and heifers through RNA-seq analysis. Consequently, we wanted to assess the known role of niacin in the physiological processes of vasodilation, detoxification, and immune function in beef hepatic tissue. Normal weaned calves (~8 months old) were provided either a control diet or a diet supplemented with rumen-protected niacin (6 g/hd/d) for a 30-day period, followed by a liver biopsy. We observed a significant list of changes at the transcriptome level due to rumen-protected niacin supplementation. Several metabolic pathways revealed potential positive effects to the animal's liver metabolism due to administration of rumen-protected niacin; for example, a decrease in lipolysis, apoptosis, inflammatory responses, atherosclerosis, oxidative stress, fibrosis, and vasodilation-related pathways. Therefore, results from our study showed that the liver transcriptional machinery switched several metabolic pathways to a condition that could potentially benefit the health status of animals supplemented with rumen-protected niacin. In conclusion, based on the results of our study, we can suggest the utilization of rumen-protected niacin supplementation as a nutritional strategy could improve the health status of growing beef cattle in different beef production stages, such as backgrounding operations or new arrivals to a feedlot. |
| format | Article |
| id | doaj-art-4839f688ce224134ad29189262774fe0 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-4839f688ce224134ad29189262774fe02025-01-21T05:31:24ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-01188e028940910.1371/journal.pone.0289409Hepatic transcript profiling in beef cattle: Effects of rumen-protected niacin supplementation.Gastón F AlfaroValentino PalomboMariasilvia D'AndreaWenqi CaoYue ZhangJonathan BeeverRussell B MuntiferingWilmer J PachecoSoren P RodningXu WangSonia J MoisáThe objective of our study was to assess the effect of rumen-protected niacin supplementation on the transcriptome of liver tissue in growing Angus × Simmental steers and heifers through RNA-seq analysis. Consequently, we wanted to assess the known role of niacin in the physiological processes of vasodilation, detoxification, and immune function in beef hepatic tissue. Normal weaned calves (~8 months old) were provided either a control diet or a diet supplemented with rumen-protected niacin (6 g/hd/d) for a 30-day period, followed by a liver biopsy. We observed a significant list of changes at the transcriptome level due to rumen-protected niacin supplementation. Several metabolic pathways revealed potential positive effects to the animal's liver metabolism due to administration of rumen-protected niacin; for example, a decrease in lipolysis, apoptosis, inflammatory responses, atherosclerosis, oxidative stress, fibrosis, and vasodilation-related pathways. Therefore, results from our study showed that the liver transcriptional machinery switched several metabolic pathways to a condition that could potentially benefit the health status of animals supplemented with rumen-protected niacin. In conclusion, based on the results of our study, we can suggest the utilization of rumen-protected niacin supplementation as a nutritional strategy could improve the health status of growing beef cattle in different beef production stages, such as backgrounding operations or new arrivals to a feedlot.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0289409&type=printable |
| spellingShingle | Gastón F Alfaro Valentino Palombo Mariasilvia D'Andrea Wenqi Cao Yue Zhang Jonathan Beever Russell B Muntifering Wilmer J Pacheco Soren P Rodning Xu Wang Sonia J Moisá Hepatic transcript profiling in beef cattle: Effects of rumen-protected niacin supplementation. PLoS ONE |
| title | Hepatic transcript profiling in beef cattle: Effects of rumen-protected niacin supplementation. |
| title_full | Hepatic transcript profiling in beef cattle: Effects of rumen-protected niacin supplementation. |
| title_fullStr | Hepatic transcript profiling in beef cattle: Effects of rumen-protected niacin supplementation. |
| title_full_unstemmed | Hepatic transcript profiling in beef cattle: Effects of rumen-protected niacin supplementation. |
| title_short | Hepatic transcript profiling in beef cattle: Effects of rumen-protected niacin supplementation. |
| title_sort | hepatic transcript profiling in beef cattle effects of rumen protected niacin supplementation |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0289409&type=printable |
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