Discovery of Novel Pyrrolidine-Based Chalcones as Dual Inhibitors of α‑Amylase and α‑Glucosidase: Synthesis, Molecular Docking, ADMET Profiles, and Pharmacological Screening
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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American Chemical Society
2025-02-01
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| Series: | ACS Omega |
| Online Access: | https://doi.org/10.1021/acsomega.4c10095 |
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| author | Bedriye Seda Kurşun Aktar Yusuf Sıcak Abdulkadir Bakırdöven Gizem Tatar Yılmaz Özlem Yılmaz Ayşegül Karaküçük-İyidoğan Demet Taşdemir Ebru Sağlam Emine Elçin Oruç-Emre |
| author_facet | Bedriye Seda Kurşun Aktar Yusuf Sıcak Abdulkadir Bakırdöven Gizem Tatar Yılmaz Özlem Yılmaz Ayşegül Karaküçük-İyidoğan Demet Taşdemir Ebru Sağlam Emine Elçin Oruç-Emre |
| author_sort | Bedriye Seda Kurşun Aktar |
| collection | DOAJ |
| format | Article |
| id | doaj-art-4838ce46bc7d430bbacc33f1f1fe0841 |
| institution | DOAJ |
| issn | 2470-1343 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | American Chemical Society |
| record_format | Article |
| series | ACS Omega |
| spelling | doaj-art-4838ce46bc7d430bbacc33f1f1fe08412025-08-20T02:57:55ZengAmerican Chemical SocietyACS Omega2470-13432025-02-011099368938010.1021/acsomega.4c10095Discovery of Novel Pyrrolidine-Based Chalcones as Dual Inhibitors of α‑Amylase and α‑Glucosidase: Synthesis, Molecular Docking, ADMET Profiles, and Pharmacological ScreeningBedriye Seda Kurşun Aktar0Yusuf Sıcak1Abdulkadir Bakırdöven2Gizem Tatar Yılmaz3Özlem Yılmaz4Ayşegül Karaküçük-İyidoğan5Demet Taşdemir6Ebru Sağlam7Emine Elçin Oruç-Emre8Department of Hair Care and Beauty Services, Yeşilyurt Vocational School, Malatya Turgut Özal University, Malatya, TürkiyeDepartment of Medicinal and Aromatic Plants, Köyceğiz Vocational School, Mugla Sitki Kocman University, Muğla, TürkiyeDepartment of Hair Care and Beauty Services, Yeşilyurt Vocational School, Malatya Turgut Özal University, Malatya, TürkiyeDepartment of Biostatistics and Medical Informatics, Faculty of Medicine, Karadeniz Technical University, Trabzon, TürkiyeDepartment of Chemistry, Faculty of Arts and Sciences, Tokat Gaziosmanpaşa University, Tokat, TürkiyeDepartment of Chemistry, Faculty of Arts and Sciences, Gaziantep University, Gaziantep, TürkiyeDepartment of Medical Biochemistry, Faculty of Medicine, Gaziantep University, Gaziantep, TürkiyeRespiratory Diseases and Respiratory Surgery Research and Practice Center, Gaziantep University, Gaziantep, TürkiyeDepartment of Chemistry, Faculty of Arts and Sciences, Gaziantep University, Gaziantep, Türkiyehttps://doi.org/10.1021/acsomega.4c10095 |
| spellingShingle | Bedriye Seda Kurşun Aktar Yusuf Sıcak Abdulkadir Bakırdöven Gizem Tatar Yılmaz Özlem Yılmaz Ayşegül Karaküçük-İyidoğan Demet Taşdemir Ebru Sağlam Emine Elçin Oruç-Emre Discovery of Novel Pyrrolidine-Based Chalcones as Dual Inhibitors of α‑Amylase and α‑Glucosidase: Synthesis, Molecular Docking, ADMET Profiles, and Pharmacological Screening ACS Omega |
| title | Discovery of Novel Pyrrolidine-Based Chalcones as Dual Inhibitors of α‑Amylase and α‑Glucosidase: Synthesis, Molecular Docking, ADMET Profiles, and Pharmacological Screening |
| title_full | Discovery of Novel Pyrrolidine-Based Chalcones as Dual Inhibitors of α‑Amylase and α‑Glucosidase: Synthesis, Molecular Docking, ADMET Profiles, and Pharmacological Screening |
| title_fullStr | Discovery of Novel Pyrrolidine-Based Chalcones as Dual Inhibitors of α‑Amylase and α‑Glucosidase: Synthesis, Molecular Docking, ADMET Profiles, and Pharmacological Screening |
| title_full_unstemmed | Discovery of Novel Pyrrolidine-Based Chalcones as Dual Inhibitors of α‑Amylase and α‑Glucosidase: Synthesis, Molecular Docking, ADMET Profiles, and Pharmacological Screening |
| title_short | Discovery of Novel Pyrrolidine-Based Chalcones as Dual Inhibitors of α‑Amylase and α‑Glucosidase: Synthesis, Molecular Docking, ADMET Profiles, and Pharmacological Screening |
| title_sort | discovery of novel pyrrolidine based chalcones as dual inhibitors of α amylase and α glucosidase synthesis molecular docking admet profiles and pharmacological screening |
| url | https://doi.org/10.1021/acsomega.4c10095 |
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