Comparison of Biological Properties and Clinical Application of Mesenchymal Stem Cells from the Mesoderm and Ectoderm
Since the discovery of mesenchymal stem cells (MSCs) in the 1970s, they have been widely used in the treatment of a variety of diseases because of their wide sources, strong differentiation potential, rapid expansion in vitro, low immunogenicity, and so on. At present, most of the related research i...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2023/4547875 |
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| _version_ | 1832546726383190016 |
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| author | Zhenning Wang Meng Huang Yu Zhang Xiaoxia Jiang Lulu Xu |
| author_facet | Zhenning Wang Meng Huang Yu Zhang Xiaoxia Jiang Lulu Xu |
| author_sort | Zhenning Wang |
| collection | DOAJ |
| description | Since the discovery of mesenchymal stem cells (MSCs) in the 1970s, they have been widely used in the treatment of a variety of diseases because of their wide sources, strong differentiation potential, rapid expansion in vitro, low immunogenicity, and so on. At present, most of the related research is on mesoderm-derived MSCs (M-MSCs) such as bone marrow MSCs and adipose-derived MSCs. As a type of MSC, ectoderm-derived MSCs (E-MSCs) have a stronger potential for self-renewal, multidirectional differentiation, and immunomodulation and have more advantages than M-MSCs in some specific conditions. This paper analyzes the relevant research development of E-MSCs compared with that of M-MSCs; summarizes the extraction, discrimination and culture, biological characteristics, and clinical application of E-MSCs; and discusses the application prospects of E-MSCs. This summary provides a theoretical basis for the better application of MSCs from both ectoderm and mesoderm in the future. |
| format | Article |
| id | doaj-art-483501c0c8774d55bfdfbd71e18e652c |
| institution | Kabale University |
| issn | 1687-9678 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-483501c0c8774d55bfdfbd71e18e652c2025-02-03T06:47:21ZengWileyStem Cells International1687-96782023-01-01202310.1155/2023/4547875Comparison of Biological Properties and Clinical Application of Mesenchymal Stem Cells from the Mesoderm and EctodermZhenning Wang0Meng Huang1Yu Zhang2Xiaoxia Jiang3Lulu Xu4Medical School of Chinese PLAMedical School of Chinese PLAMedical School of Chinese PLABeijing Institute of Basic Medical SciencesDepartment of OrthodonticsSince the discovery of mesenchymal stem cells (MSCs) in the 1970s, they have been widely used in the treatment of a variety of diseases because of their wide sources, strong differentiation potential, rapid expansion in vitro, low immunogenicity, and so on. At present, most of the related research is on mesoderm-derived MSCs (M-MSCs) such as bone marrow MSCs and adipose-derived MSCs. As a type of MSC, ectoderm-derived MSCs (E-MSCs) have a stronger potential for self-renewal, multidirectional differentiation, and immunomodulation and have more advantages than M-MSCs in some specific conditions. This paper analyzes the relevant research development of E-MSCs compared with that of M-MSCs; summarizes the extraction, discrimination and culture, biological characteristics, and clinical application of E-MSCs; and discusses the application prospects of E-MSCs. This summary provides a theoretical basis for the better application of MSCs from both ectoderm and mesoderm in the future.http://dx.doi.org/10.1155/2023/4547875 |
| spellingShingle | Zhenning Wang Meng Huang Yu Zhang Xiaoxia Jiang Lulu Xu Comparison of Biological Properties and Clinical Application of Mesenchymal Stem Cells from the Mesoderm and Ectoderm Stem Cells International |
| title | Comparison of Biological Properties and Clinical Application of Mesenchymal Stem Cells from the Mesoderm and Ectoderm |
| title_full | Comparison of Biological Properties and Clinical Application of Mesenchymal Stem Cells from the Mesoderm and Ectoderm |
| title_fullStr | Comparison of Biological Properties and Clinical Application of Mesenchymal Stem Cells from the Mesoderm and Ectoderm |
| title_full_unstemmed | Comparison of Biological Properties and Clinical Application of Mesenchymal Stem Cells from the Mesoderm and Ectoderm |
| title_short | Comparison of Biological Properties and Clinical Application of Mesenchymal Stem Cells from the Mesoderm and Ectoderm |
| title_sort | comparison of biological properties and clinical application of mesenchymal stem cells from the mesoderm and ectoderm |
| url | http://dx.doi.org/10.1155/2023/4547875 |
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