A combination of Dihydroartemisinin and Venetoclax enhances antitumor effect in AML via C-MYC/BCL-XL/MCL-1 triple targeting

A combination of Dihydroartemisinin and Venetoclax enhances antitumor effect in AML via C-MYC/BCL-XL/MCL-1 triple targeting

Abstract Background Acute myeloid leukemia (AML) is associated with high rates of resistance to standard therapies, necessitating the exploration of novel treatment strategies. Venetoclax (VEN) has shown efficacy in AML, yet drug resistance remains a significant challenge. This study aims to explore...

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Bibliographic Details
Main Authors: Fenglin Li, Yao Chen, Haihui Zhuang, Renzhi Pei, Yuyu Lu, Dong chen, Shuangyue Li, Peipei Ye, Jiaying lian, Ying Lu
Format: Article
Language:English
Published: Springer 2025-04-01
Series:Discover Oncology
Subjects:
AML VEN
DHA
MCL-1
C-MYC
Online Access:https://doi.org/10.1007/s12672-025-02242-7
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