Secretomes from Mesenchymal Stem Cells against Acute Kidney Injury: Possible Heterogeneity
A kidney has the ability to regenerate itself after a variety of renal injuries. Mesenchymal stem cells (MSCs) have been shown to ameliorate tissue damages during renal injuries and diseases. The regenerations induced by MSCs are primarily mediated by the paracrine release of soluble factors and ext...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2018/8693137 |
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| author | Kenji Tsuji Shinji Kitamura Jun Wada |
| author_facet | Kenji Tsuji Shinji Kitamura Jun Wada |
| author_sort | Kenji Tsuji |
| collection | DOAJ |
| description | A kidney has the ability to regenerate itself after a variety of renal injuries. Mesenchymal stem cells (MSCs) have been shown to ameliorate tissue damages during renal injuries and diseases. The regenerations induced by MSCs are primarily mediated by the paracrine release of soluble factors and extracellular vesicles, including exosomes and microvesicles. Extracellular vesicles contain proteins, microRNAs, and mRNAs that are transferred into recipient cells to induce several repair signaling pathways. Over the past few decades, many studies identified trophic factors from MSCs, which attenuate renal injury in a variety of animal acute kidney injury models, including renal ischemia-reperfusion injury and drug-induced renal injury, using microarray and proteomic analysis. Nevertheless, these studies have revealed the heterogeneity of trophic factors from MSCs that depend on the cell origins and different stimuli including hypoxia, inflammatory stimuli, and aging. In this review article, we summarize the secretomes and regenerative mechanisms induced by MSCs and highlight the possible heterogeneity of trophic factors from different types of MSC and different circumstances for renal regeneration. |
| format | Article |
| id | doaj-art-482ce12286914028b7cf78372a73d939 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-482ce12286914028b7cf78372a73d9392025-02-03T01:06:42ZengWileyStem Cells International1687-966X1687-96782018-01-01201810.1155/2018/86931378693137Secretomes from Mesenchymal Stem Cells against Acute Kidney Injury: Possible HeterogeneityKenji Tsuji0Shinji Kitamura1Jun Wada2Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama 700-8558, JapanDepartment of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama 700-8558, JapanDepartment of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama 700-8558, JapanA kidney has the ability to regenerate itself after a variety of renal injuries. Mesenchymal stem cells (MSCs) have been shown to ameliorate tissue damages during renal injuries and diseases. The regenerations induced by MSCs are primarily mediated by the paracrine release of soluble factors and extracellular vesicles, including exosomes and microvesicles. Extracellular vesicles contain proteins, microRNAs, and mRNAs that are transferred into recipient cells to induce several repair signaling pathways. Over the past few decades, many studies identified trophic factors from MSCs, which attenuate renal injury in a variety of animal acute kidney injury models, including renal ischemia-reperfusion injury and drug-induced renal injury, using microarray and proteomic analysis. Nevertheless, these studies have revealed the heterogeneity of trophic factors from MSCs that depend on the cell origins and different stimuli including hypoxia, inflammatory stimuli, and aging. In this review article, we summarize the secretomes and regenerative mechanisms induced by MSCs and highlight the possible heterogeneity of trophic factors from different types of MSC and different circumstances for renal regeneration.http://dx.doi.org/10.1155/2018/8693137 |
| spellingShingle | Kenji Tsuji Shinji Kitamura Jun Wada Secretomes from Mesenchymal Stem Cells against Acute Kidney Injury: Possible Heterogeneity Stem Cells International |
| title | Secretomes from Mesenchymal Stem Cells against Acute Kidney Injury: Possible Heterogeneity |
| title_full | Secretomes from Mesenchymal Stem Cells against Acute Kidney Injury: Possible Heterogeneity |
| title_fullStr | Secretomes from Mesenchymal Stem Cells against Acute Kidney Injury: Possible Heterogeneity |
| title_full_unstemmed | Secretomes from Mesenchymal Stem Cells against Acute Kidney Injury: Possible Heterogeneity |
| title_short | Secretomes from Mesenchymal Stem Cells against Acute Kidney Injury: Possible Heterogeneity |
| title_sort | secretomes from mesenchymal stem cells against acute kidney injury possible heterogeneity |
| url | http://dx.doi.org/10.1155/2018/8693137 |
| work_keys_str_mv | AT kenjitsuji secretomesfrommesenchymalstemcellsagainstacutekidneyinjurypossibleheterogeneity AT shinjikitamura secretomesfrommesenchymalstemcellsagainstacutekidneyinjurypossibleheterogeneity AT junwada secretomesfrommesenchymalstemcellsagainstacutekidneyinjurypossibleheterogeneity |