Native learning ability and not age determines the effects of brain stimulation
Abstract Healthy aging often entails a decline in cognitive and motor functions, affecting independence and quality of life in older adults. Brain stimulation shows potential to enhance these functions, but studies show variable effects. Previous studies have tried to identify responders and non-res...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-11-01
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| Series: | npj Science of Learning |
| Online Access: | https://doi.org/10.1038/s41539-024-00278-y |
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| author | Pablo Maceira-Elvira Traian Popa Anne-Christine Schmid Andéol Cadic-Melchior Henning Müller Roger Schaer Leonardo G. Cohen Friedhelm C. Hummel |
| author_facet | Pablo Maceira-Elvira Traian Popa Anne-Christine Schmid Andéol Cadic-Melchior Henning Müller Roger Schaer Leonardo G. Cohen Friedhelm C. Hummel |
| author_sort | Pablo Maceira-Elvira |
| collection | DOAJ |
| description | Abstract Healthy aging often entails a decline in cognitive and motor functions, affecting independence and quality of life in older adults. Brain stimulation shows potential to enhance these functions, but studies show variable effects. Previous studies have tried to identify responders and non-responders through correlations between behavioral change and baseline parameters, but results lack generalization to independent cohorts. We propose a method to predict an individual’s likelihood of benefiting from stimulation, based on baseline performance of a sequential motor task. Our results show that individuals with less efficient learning mechanisms benefit from stimulation, while those with optimal learning strategies experience none or even detrimental effects. This differential effect, first identified in a public dataset and replicated here in an independent cohort, was linked to one’s ability to integrate task-relevant information and not age. This study constitutes a further step towards personalized clinical-translational interventions based on brain stimulation. |
| format | Article |
| id | doaj-art-4825c9addb484e8c9c4b955edddac6e1 |
| institution | OA Journals |
| issn | 2056-7936 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Science of Learning |
| spelling | doaj-art-4825c9addb484e8c9c4b955edddac6e12025-08-20T02:08:15ZengNature Portfolionpj Science of Learning2056-79362024-11-019111110.1038/s41539-024-00278-yNative learning ability and not age determines the effects of brain stimulationPablo Maceira-Elvira0Traian Popa1Anne-Christine Schmid2Andéol Cadic-Melchior3Henning Müller4Roger Schaer5Leonardo G. Cohen6Friedhelm C. Hummel7Defitech Chair for Clinical Neuroengineering, Neuro-X Institute (INX), École Polytechnique Fédérale de Lausanne (EPFL)Defitech Chair for Clinical Neuroengineering, Neuro-X Institute (INX), École Polytechnique Fédérale de Lausanne (EPFL)Defitech Chair for Clinical Neuroengineering, Neuro-X Institute (INX), École Polytechnique Fédérale de Lausanne (EPFL)Defitech Chair for Clinical Neuroengineering, Neuro-X Institute (INX), École Polytechnique Fédérale de Lausanne (EPFL)University of Applied Sciences Western Switzerland (HES-SO)University of Applied Sciences Western Switzerland (HES-SO)Human Cortical Physiology and Neurorehabilitation Section, NINDS, NIHDefitech Chair for Clinical Neuroengineering, Neuro-X Institute (INX), École Polytechnique Fédérale de Lausanne (EPFL)Abstract Healthy aging often entails a decline in cognitive and motor functions, affecting independence and quality of life in older adults. Brain stimulation shows potential to enhance these functions, but studies show variable effects. Previous studies have tried to identify responders and non-responders through correlations between behavioral change and baseline parameters, but results lack generalization to independent cohorts. We propose a method to predict an individual’s likelihood of benefiting from stimulation, based on baseline performance of a sequential motor task. Our results show that individuals with less efficient learning mechanisms benefit from stimulation, while those with optimal learning strategies experience none or even detrimental effects. This differential effect, first identified in a public dataset and replicated here in an independent cohort, was linked to one’s ability to integrate task-relevant information and not age. This study constitutes a further step towards personalized clinical-translational interventions based on brain stimulation.https://doi.org/10.1038/s41539-024-00278-y |
| spellingShingle | Pablo Maceira-Elvira Traian Popa Anne-Christine Schmid Andéol Cadic-Melchior Henning Müller Roger Schaer Leonardo G. Cohen Friedhelm C. Hummel Native learning ability and not age determines the effects of brain stimulation npj Science of Learning |
| title | Native learning ability and not age determines the effects of brain stimulation |
| title_full | Native learning ability and not age determines the effects of brain stimulation |
| title_fullStr | Native learning ability and not age determines the effects of brain stimulation |
| title_full_unstemmed | Native learning ability and not age determines the effects of brain stimulation |
| title_short | Native learning ability and not age determines the effects of brain stimulation |
| title_sort | native learning ability and not age determines the effects of brain stimulation |
| url | https://doi.org/10.1038/s41539-024-00278-y |
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