Therapeutic bullfrog oil-based nanoemulsion for oral application: Development, characterization and stability
The aim of this study was to develop, optimize, and characterize a stable therapeutic bullfrog oil based nanoemulsion for oral application using a rational experimental design approach. The optimized oral nanoemulsion contained 0.2 % sodium benzoate and 0.02 % propyl-paraben as preservatives; 0.1 %...
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| Format: | Article |
| Language: | English |
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Sciendo
2019-03-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2019-0001 |
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| author | Rutckeviski Renata Xavier Francisco Humberto Morais Andreza Rochelle Do Vale Amaral-Machado Lucas Alencar Everton Do Nascimento Genre Julieta De Souza Araujo Adriano Antunes Egito Eryvaldo Socrates Tabosa Do |
| author_facet | Rutckeviski Renata Xavier Francisco Humberto Morais Andreza Rochelle Do Vale Amaral-Machado Lucas Alencar Everton Do Nascimento Genre Julieta De Souza Araujo Adriano Antunes Egito Eryvaldo Socrates Tabosa Do |
| author_sort | Rutckeviski Renata |
| collection | DOAJ |
| description | The aim of this study was to develop, optimize, and characterize a stable therapeutic bullfrog oil based nanoemulsion for oral application using a rational experimental design approach. The optimized oral nanoemulsion contained 0.2 % sodium benzoate and 0.02 % propyl-paraben as preservatives; 0.1 % sucralose and 0.4 % acesulfam K as sweeteners and 0.1 % tutti-frutti as flavoring to mask the unpleasant organoleptic characteristics of bullfrog oil. The oral O/W-nanoemulsion showed the droplet size, PDI, zeta potential, and pH of 410 ± 8 nm, 0.20 ± 0.02, –38 ± 2.5 mV, and 6.43 ± 0.05, respectively. The optimized oral nanoemulsion showed a milky single-phase and optimal physical stability at 25 °C for 90 days. Indeed, higher oxidation induction time and lower formation of peroxides in the oral nanoemulsion were responsible for improving its stability. A therapeutic delivery system containing bullfrog oil for oral application was successfully developed and optimized with ideal thermo-oxidative stability. |
| format | Article |
| id | doaj-art-481f483f5a254e9784e95345c89c7142 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2019-03-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-481f483f5a254e9784e95345c89c71422025-02-02T17:01:54ZengSciendoActa Pharmaceutica1846-95582019-03-01691334810.2478/acph-2019-0001acph-2019-0001Therapeutic bullfrog oil-based nanoemulsion for oral application: Development, characterization and stabilityRutckeviski Renata0Xavier Francisco Humberto1Morais Andreza Rochelle Do Vale2Amaral-Machado Lucas3Alencar Everton Do Nascimento4Genre Julieta5De Souza Araujo Adriano Antunes6Egito Eryvaldo Socrates Tabosa Do7Universidade Federal do Rio Grande do Norte (UFRN), Programa de Pós-graduação em Ciências Farmacêuticas, Departamento de Farmácia, 59010-180, Natal–RN, BrazilUFRN, Laboratório de Sistemas Dispersos (LaSiD), Departamento de Farmácia59010-180, Natal–RN, BrazilUFRN, Laboratório de Sistemas Dispersos (LaSiD), Departamento de Farmácia59010-180, Natal–RN, BrazilUFRN, Laboratório de Sistemas Dispersos (LaSiD), Departamento de Farmácia59010-180, Natal–RN, BrazilUFRN, Laboratório de Sistemas Dispersos (LaSiD), Departamento de Farmácia59010-180, Natal–RN, BrazilUFRN, Laboratório de Sistemas Dispersos (LaSiD), Departamento de Farmácia59010-180, Natal–RN, BrazilUniversidade Federal de SergipeDepartamento de Farmácia. 49100-000São Cristovão–SE, BrazilUniversidade Federal do Rio Grande do Norte (UFRN), Programa de Pós-graduação em Ciências Farmacêuticas, Departamento de Farmácia, 59010-180, Natal–RN, BrazilThe aim of this study was to develop, optimize, and characterize a stable therapeutic bullfrog oil based nanoemulsion for oral application using a rational experimental design approach. The optimized oral nanoemulsion contained 0.2 % sodium benzoate and 0.02 % propyl-paraben as preservatives; 0.1 % sucralose and 0.4 % acesulfam K as sweeteners and 0.1 % tutti-frutti as flavoring to mask the unpleasant organoleptic characteristics of bullfrog oil. The oral O/W-nanoemulsion showed the droplet size, PDI, zeta potential, and pH of 410 ± 8 nm, 0.20 ± 0.02, –38 ± 2.5 mV, and 6.43 ± 0.05, respectively. The optimized oral nanoemulsion showed a milky single-phase and optimal physical stability at 25 °C for 90 days. Indeed, higher oxidation induction time and lower formation of peroxides in the oral nanoemulsion were responsible for improving its stability. A therapeutic delivery system containing bullfrog oil for oral application was successfully developed and optimized with ideal thermo-oxidative stability.https://doi.org/10.2478/acph-2019-0001bullfrog oilnanoemulsionthermo-oxidative stabilityexperimental designoral applicationtherapeutic nanosystem |
| spellingShingle | Rutckeviski Renata Xavier Francisco Humberto Morais Andreza Rochelle Do Vale Amaral-Machado Lucas Alencar Everton Do Nascimento Genre Julieta De Souza Araujo Adriano Antunes Egito Eryvaldo Socrates Tabosa Do Therapeutic bullfrog oil-based nanoemulsion for oral application: Development, characterization and stability Acta Pharmaceutica bullfrog oil nanoemulsion thermo-oxidative stability experimental design oral application therapeutic nanosystem |
| title | Therapeutic bullfrog oil-based nanoemulsion for oral application: Development, characterization and stability |
| title_full | Therapeutic bullfrog oil-based nanoemulsion for oral application: Development, characterization and stability |
| title_fullStr | Therapeutic bullfrog oil-based nanoemulsion for oral application: Development, characterization and stability |
| title_full_unstemmed | Therapeutic bullfrog oil-based nanoemulsion for oral application: Development, characterization and stability |
| title_short | Therapeutic bullfrog oil-based nanoemulsion for oral application: Development, characterization and stability |
| title_sort | therapeutic bullfrog oil based nanoemulsion for oral application development characterization and stability |
| topic | bullfrog oil nanoemulsion thermo-oxidative stability experimental design oral application therapeutic nanosystem |
| url | https://doi.org/10.2478/acph-2019-0001 |
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