Differential Neutralization Profiles of 17DD Vaccinated Population to 17D-204 and 17DD Vaccine Strains
<b>Background/Objectives</b>: Yellow fever virus (YFV) (<i>Flaviviridae</i>, <i>Orthoflavivirus</i>) is the etiologic agent of yellow fever (YF), a vector-borne disease with significant morbidity and mortality across the tropics and neotropics, despite having a hi...
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MDPI AG
2024-11-01
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| author | Ana C. B. Terzian Sasha R. Azar Cassia F. Estofolete Mauricio L. Nogueira Nikos Vasilakis |
| author_facet | Ana C. B. Terzian Sasha R. Azar Cassia F. Estofolete Mauricio L. Nogueira Nikos Vasilakis |
| author_sort | Ana C. B. Terzian |
| collection | DOAJ |
| description | <b>Background/Objectives</b>: Yellow fever virus (YFV) (<i>Flaviviridae</i>, <i>Orthoflavivirus</i>) is the etiologic agent of yellow fever (YF), a vector-borne disease with significant morbidity and mortality across the tropics and neotropics, despite having a highly efficacious and safe vaccine (17D). Vaccination provides lifelong protection from YF disease mediated by humoral immunity. There are several versions of the original 17D vaccine: 17D-204 (marketed in the USA as YF-VAX, in France as Stamaril, and in China as Tiantan-V), 17D-213 (Russian Federation), and 17DD (by FIOCRUZ in Brazil). Vaccines produced in the US, France, Senegal, China, and Russia represent 17D-204-derived strains, whereas the Brazilian 17DD has a unique passage/attenuation history from 17D-204-derived strains. Their functional differences in the neutralization profiles are not known. <b>Methods</b>: The Plaque Reduction Neutralization Test (PRNT) was used to determine the neutralization profiles of sera from 209 patients that were previously vaccinated with the 17DD strain against both 17D-204 and 17DD. <b>Results</b>: Sera exhibited significantly more efficient neutralization of 17DD (mean reciprocal PRNT<sub>50</sub> 183, PRNT<sub>80</sub> 86, median reciprocal PRNT<sub>50</sub> 80, and PRNT<sub>80</sub> 40) compared to 17D-204 (mean reciprocal PRNT<sub>50</sub> 91, PRNT<sub>80</sub> 33, median reciprocal PRNT<sub>50</sub> 40, and PRNT<sub>80</sub> 10). <b>Conclusions</b>: Our data indicate antigenic differences between 17D and 17DD vaccines. |
| format | Article |
| id | doaj-art-481e72f5ffc8498d93fb36dab72f078e |
| institution | Kabale University |
| issn | 2076-393X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj-art-481e72f5ffc8498d93fb36dab72f078e2024-12-27T14:57:49ZengMDPI AGVaccines2076-393X2024-11-011212131110.3390/vaccines12121311Differential Neutralization Profiles of 17DD Vaccinated Population to 17D-204 and 17DD Vaccine StrainsAna C. B. Terzian0Sasha R. Azar1Cassia F. Estofolete2Mauricio L. Nogueira3Nikos Vasilakis4Laboratório de Imunologia Celular e Molecular, Instituto René Rachou, Fundação Osvaldo Cruz, Belo Horizonte 30190-009, MG, BrazilCenter for Tissue Engineering, Department of Surgery, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX 77030-2703, USALaboratório de Pesquisas em Virologia, Departamento de Doenças Dermatológicas, Infecciosas e Parasitárias, Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto 15090-000, SP, BrazilLaboratório de Pesquisas em Virologia, Departamento de Doenças Dermatológicas, Infecciosas e Parasitárias, Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto 15090-000, SP, BrazilDepartment of Pathology, University of Texas Medical Branch, Galveston, TX 77555-0609, USA<b>Background/Objectives</b>: Yellow fever virus (YFV) (<i>Flaviviridae</i>, <i>Orthoflavivirus</i>) is the etiologic agent of yellow fever (YF), a vector-borne disease with significant morbidity and mortality across the tropics and neotropics, despite having a highly efficacious and safe vaccine (17D). Vaccination provides lifelong protection from YF disease mediated by humoral immunity. There are several versions of the original 17D vaccine: 17D-204 (marketed in the USA as YF-VAX, in France as Stamaril, and in China as Tiantan-V), 17D-213 (Russian Federation), and 17DD (by FIOCRUZ in Brazil). Vaccines produced in the US, France, Senegal, China, and Russia represent 17D-204-derived strains, whereas the Brazilian 17DD has a unique passage/attenuation history from 17D-204-derived strains. Their functional differences in the neutralization profiles are not known. <b>Methods</b>: The Plaque Reduction Neutralization Test (PRNT) was used to determine the neutralization profiles of sera from 209 patients that were previously vaccinated with the 17DD strain against both 17D-204 and 17DD. <b>Results</b>: Sera exhibited significantly more efficient neutralization of 17DD (mean reciprocal PRNT<sub>50</sub> 183, PRNT<sub>80</sub> 86, median reciprocal PRNT<sub>50</sub> 80, and PRNT<sub>80</sub> 40) compared to 17D-204 (mean reciprocal PRNT<sub>50</sub> 91, PRNT<sub>80</sub> 33, median reciprocal PRNT<sub>50</sub> 40, and PRNT<sub>80</sub> 10). <b>Conclusions</b>: Our data indicate antigenic differences between 17D and 17DD vaccines.https://www.mdpi.com/2076-393X/12/12/1311YFVvaccineimmune responseneutralizing antibodies |
| spellingShingle | Ana C. B. Terzian Sasha R. Azar Cassia F. Estofolete Mauricio L. Nogueira Nikos Vasilakis Differential Neutralization Profiles of 17DD Vaccinated Population to 17D-204 and 17DD Vaccine Strains Vaccines YFV vaccine immune response neutralizing antibodies |
| title | Differential Neutralization Profiles of 17DD Vaccinated Population to 17D-204 and 17DD Vaccine Strains |
| title_full | Differential Neutralization Profiles of 17DD Vaccinated Population to 17D-204 and 17DD Vaccine Strains |
| title_fullStr | Differential Neutralization Profiles of 17DD Vaccinated Population to 17D-204 and 17DD Vaccine Strains |
| title_full_unstemmed | Differential Neutralization Profiles of 17DD Vaccinated Population to 17D-204 and 17DD Vaccine Strains |
| title_short | Differential Neutralization Profiles of 17DD Vaccinated Population to 17D-204 and 17DD Vaccine Strains |
| title_sort | differential neutralization profiles of 17dd vaccinated population to 17d 204 and 17dd vaccine strains |
| topic | YFV vaccine immune response neutralizing antibodies |
| url | https://www.mdpi.com/2076-393X/12/12/1311 |
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