Functional Characterization of the Osteoarthritis Susceptibility Mapping to CHST11-A Bioinformatics and Molecular Study.
The single nucleotide polymorphism (SNP) rs835487 is associated with hip osteoarthritis (OA) at the genome-wide significance level and is located within CHST11, which codes for carbohydrate sulfotransferase 11. This enzyme post-translationally modifies proteoglycan prior to its deposition in the car...
Saved in:
| Main Authors: | Louise N Reynard, Madhushika Ratnayake, Mauro Santibanez-Koref, John Loughlin |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2016-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0159024&type=printable |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Human chondrocytes respond discordantly to the protein encoded by the osteoarthritis susceptibility gene GDF5.
by: Madhushika Ratnayake, et al.
Published: (2014-01-01) -
A consistent and potentially exploitable response during chondrogenesis of mesenchymal stem cells from osteoarthritis patients to the protein encoded by the susceptibility gene GDF5.
by: Madhushika Ratnayake, et al.
Published: (2017-01-01) -
The identification of trans-acting factors that regulate the expression of GDF5 via the osteoarthritis susceptibility SNP rs143383.
by: Catherine M Syddall, et al.
Published: (2013-06-01) -
Surgical management of endometrial cancer in patient with musculocontractural Ehlers-Danlos Syndrome harboring pathogenic variants in CHST14 (mcEDS-CHST14): A case report
by: Yuta Shioya, et al.
Published: (2025-02-01) -
CHST3, PGBD5, and SLIT2 can be identified as potential genes for the diagnosis and treatment of osteoporosis and sarcopenia
by: Xingyao Yang, et al.
Published: (2025-01-01)