Ovarian sensitivity index affects clinical pregnancy and live birth rates in gonadotropin-releasing hormone agonist and antagonist in vitro fertilization cycles
ObjectivesThis study aimed to investigate the correlation of ovarian sensitivity index (OSI) and clinical parameters in IVF treatments.MethodsIVF data files between January 2011 and December 2020 in a single unit were included. The primary outcome measure was the correlation between the OSI and clin...
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1457435/full |
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| author | Chao Chin Hsu Chao Chin Hsu Isabel Hsu Sonam Dorjee Yi Chun Chen Tzu Ning Chen Yu Lin Chuang |
| author_facet | Chao Chin Hsu Chao Chin Hsu Isabel Hsu Sonam Dorjee Yi Chun Chen Tzu Ning Chen Yu Lin Chuang |
| author_sort | Chao Chin Hsu |
| collection | DOAJ |
| description | ObjectivesThis study aimed to investigate the correlation of ovarian sensitivity index (OSI) and clinical parameters in IVF treatments.MethodsIVF data files between January 2011 and December 2020 in a single unit were included. The primary outcome measure was the correlation between the OSI and clinical pregnancy and live birth rates. A generalized linear model was employed to assess group differences while controlling for age. Correlations between the OSI and clinical parameters were analyzed using Pearson’s correlation test.ResultsIn total, 1,627 patient data were reviewed, comprising 1,160 patients who received GnRH antagonists and 467 who received GnRH agonists. There was no difference in the incidence of premature ovulation and LH surge in women receiving either GnRH antagonists or agonists. A higher number of mature oocytes and good embryos were obtained in the GnRH agonist cycles. No differences were observed in pregnancy and live birth rates between both groups. Regarding the correlation of the OSI with clinical parameters, serum anti-Müllerian hormone, cycle day 2 follicle-stimulating hormone, LH, and estradiol concentrations, numbers of larger follicles, fertilization rate, and the incidence of premature LH surge were positively correlated with the OSI. Whereas the body mass index, mature oocytes obtained, embryo transfer number, and dose of GnRH antagonists were negatively correlated with the OSI. In the GnRH antagonists group, an OSI of 225.75 significantly distinguished pregnancy from non-pregnancy (p < 0.001), with an AUC of 0.615, and an OSI of 208.62 significantly distinguished live births from non-live births (p < 0.001), with an AUC of 0.637. As for the GnRH agonist group, an OSI of 228 significantly distinguished live births from non-live births, (p =0.020) with an AUC of 0.569.ConclusionWe demonstrated the capability of employing OSI to distinguish the clinical pregnancy and live birth outcomes in IVF cycles. |
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| institution | OA Journals |
| issn | 1664-2392 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj-art-48120c745c654b89acffed983421cecf2025-08-20T02:38:15ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-12-011510.3389/fendo.2024.14574351457435Ovarian sensitivity index affects clinical pregnancy and live birth rates in gonadotropin-releasing hormone agonist and antagonist in vitro fertilization cyclesChao Chin Hsu0Chao Chin Hsu1Isabel Hsu2Sonam Dorjee3Yi Chun Chen4Tzu Ning Chen5Yu Lin Chuang6Taiwan United Birth-Promoting Experts Fertility Clinic, Tainan, TaiwanDepartment of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei, TaiwanDepartment of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei, TaiwanTaiwan United Birth-Promoting Experts Fertility Clinic, Tainan, TaiwanTaiwan United Birth-Promoting Experts Fertility Clinic, Tainan, TaiwanTaiwan United Birth-Promoting Experts Fertility Clinic, Tainan, TaiwanTaiwan United Birth-Promoting Experts Fertility Clinic, Tainan, TaiwanObjectivesThis study aimed to investigate the correlation of ovarian sensitivity index (OSI) and clinical parameters in IVF treatments.MethodsIVF data files between January 2011 and December 2020 in a single unit were included. The primary outcome measure was the correlation between the OSI and clinical pregnancy and live birth rates. A generalized linear model was employed to assess group differences while controlling for age. Correlations between the OSI and clinical parameters were analyzed using Pearson’s correlation test.ResultsIn total, 1,627 patient data were reviewed, comprising 1,160 patients who received GnRH antagonists and 467 who received GnRH agonists. There was no difference in the incidence of premature ovulation and LH surge in women receiving either GnRH antagonists or agonists. A higher number of mature oocytes and good embryos were obtained in the GnRH agonist cycles. No differences were observed in pregnancy and live birth rates between both groups. Regarding the correlation of the OSI with clinical parameters, serum anti-Müllerian hormone, cycle day 2 follicle-stimulating hormone, LH, and estradiol concentrations, numbers of larger follicles, fertilization rate, and the incidence of premature LH surge were positively correlated with the OSI. Whereas the body mass index, mature oocytes obtained, embryo transfer number, and dose of GnRH antagonists were negatively correlated with the OSI. In the GnRH antagonists group, an OSI of 225.75 significantly distinguished pregnancy from non-pregnancy (p < 0.001), with an AUC of 0.615, and an OSI of 208.62 significantly distinguished live births from non-live births (p < 0.001), with an AUC of 0.637. As for the GnRH agonist group, an OSI of 228 significantly distinguished live births from non-live births, (p =0.020) with an AUC of 0.569.ConclusionWe demonstrated the capability of employing OSI to distinguish the clinical pregnancy and live birth outcomes in IVF cycles.https://www.frontiersin.org/articles/10.3389/fendo.2024.1457435/fullGnRH-agonistGnRH-antagonistovarian sensitivity indexcontrolled ovarian hyperstimulationin vitro fertilizationclinical pregnancy rate |
| spellingShingle | Chao Chin Hsu Chao Chin Hsu Isabel Hsu Sonam Dorjee Yi Chun Chen Tzu Ning Chen Yu Lin Chuang Ovarian sensitivity index affects clinical pregnancy and live birth rates in gonadotropin-releasing hormone agonist and antagonist in vitro fertilization cycles Frontiers in Endocrinology GnRH-agonist GnRH-antagonist ovarian sensitivity index controlled ovarian hyperstimulation in vitro fertilization clinical pregnancy rate |
| title | Ovarian sensitivity index affects clinical pregnancy and live birth rates in gonadotropin-releasing hormone agonist and antagonist in vitro fertilization cycles |
| title_full | Ovarian sensitivity index affects clinical pregnancy and live birth rates in gonadotropin-releasing hormone agonist and antagonist in vitro fertilization cycles |
| title_fullStr | Ovarian sensitivity index affects clinical pregnancy and live birth rates in gonadotropin-releasing hormone agonist and antagonist in vitro fertilization cycles |
| title_full_unstemmed | Ovarian sensitivity index affects clinical pregnancy and live birth rates in gonadotropin-releasing hormone agonist and antagonist in vitro fertilization cycles |
| title_short | Ovarian sensitivity index affects clinical pregnancy and live birth rates in gonadotropin-releasing hormone agonist and antagonist in vitro fertilization cycles |
| title_sort | ovarian sensitivity index affects clinical pregnancy and live birth rates in gonadotropin releasing hormone agonist and antagonist in vitro fertilization cycles |
| topic | GnRH-agonist GnRH-antagonist ovarian sensitivity index controlled ovarian hyperstimulation in vitro fertilization clinical pregnancy rate |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1457435/full |
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