New Triterpenoids from the Leaves of <i>Heritiera littoralis</i> and Their Anti-Inflammatory Activity
Six new triterpenoids, heritieras C–H (<b>1</b>–<b>6</b>), along with thirteen known triterpenoids (<b>7</b>–<b>19</b>), were isolated from the leaves of <i>Heritiera littoralis</i>. Their structures were identified by spectroscopic analysi...
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MDPI AG
2024-12-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/30/1/131 |
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| author | Chenyang Ren Xiaoqin Liang Rui Pi Jiwen Xin Bo Yang Qingfang Zheng Yanqin Li Jun Li Yanjun Zhang |
| author_facet | Chenyang Ren Xiaoqin Liang Rui Pi Jiwen Xin Bo Yang Qingfang Zheng Yanqin Li Jun Li Yanjun Zhang |
| author_sort | Chenyang Ren |
| collection | DOAJ |
| description | Six new triterpenoids, heritieras C–H (<b>1</b>–<b>6</b>), along with thirteen known triterpenoids (<b>7</b>–<b>19</b>), were isolated from the leaves of <i>Heritiera littoralis</i>. Their structures were identified by spectroscopic analysis, including 1D and 2D nuclear magnetic resonance (NMR), high-resolution electrospray ionization mass spectrometry (HRESIMS), and by comparison with the literature. Anti-inflammatory activity of the isolates was evaluated using the lipopolysaccharide (LPS) stimulated RAW 264.7 cell model. Among the isolated triterpenoid, compounds <b>1</b>, <b>12</b>, <b>16</b>, <b>17</b>, and <b>18</b> demonstrated inhibitory activity against nitric oxide (NO) release, in which compound <b>18</b> exhibited the best activity with an IC<sub>50</sub> value of 18.13 μM. The potential anti-inflammatory mechanism was investigated using molecular docking. The triterpenoids from <i>H. littoralis</i> could be served as potential candidates for the development of new anti-inflammatory agents. |
| format | Article |
| id | doaj-art-48104c4aca1b4d86976a2c9811f0dae3 |
| institution | Kabale University |
| issn | 1420-3049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-48104c4aca1b4d86976a2c9811f0dae32025-01-10T13:18:58ZengMDPI AGMolecules1420-30492024-12-0130113110.3390/molecules30010131New Triterpenoids from the Leaves of <i>Heritiera littoralis</i> and Their Anti-Inflammatory ActivityChenyang Ren0Xiaoqin Liang1Rui Pi2Jiwen Xin3Bo Yang4Qingfang Zheng5Yanqin Li6Jun Li7Yanjun Zhang8State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, ChinaState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, ChinaGuangxi Key Laboratory of Green Chemical Materials and Safety Technology, College of Petroleum and Chemical Engineering, Beibu Gulf University, Qinzhou 535000, ChinaState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, ChinaState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, ChinaState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, ChinaState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, ChinaState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, ChinaGuangxi Key Laboratory of Green Chemical Materials and Safety Technology, College of Petroleum and Chemical Engineering, Beibu Gulf University, Qinzhou 535000, ChinaSix new triterpenoids, heritieras C–H (<b>1</b>–<b>6</b>), along with thirteen known triterpenoids (<b>7</b>–<b>19</b>), were isolated from the leaves of <i>Heritiera littoralis</i>. Their structures were identified by spectroscopic analysis, including 1D and 2D nuclear magnetic resonance (NMR), high-resolution electrospray ionization mass spectrometry (HRESIMS), and by comparison with the literature. Anti-inflammatory activity of the isolates was evaluated using the lipopolysaccharide (LPS) stimulated RAW 264.7 cell model. Among the isolated triterpenoid, compounds <b>1</b>, <b>12</b>, <b>16</b>, <b>17</b>, and <b>18</b> demonstrated inhibitory activity against nitric oxide (NO) release, in which compound <b>18</b> exhibited the best activity with an IC<sub>50</sub> value of 18.13 μM. The potential anti-inflammatory mechanism was investigated using molecular docking. The triterpenoids from <i>H. littoralis</i> could be served as potential candidates for the development of new anti-inflammatory agents.https://www.mdpi.com/1420-3049/30/1/131<i>Heritiera</i><i>Heritiera littoralis</i>heritiera Cheritiera Danti-inflammatory |
| spellingShingle | Chenyang Ren Xiaoqin Liang Rui Pi Jiwen Xin Bo Yang Qingfang Zheng Yanqin Li Jun Li Yanjun Zhang New Triterpenoids from the Leaves of <i>Heritiera littoralis</i> and Their Anti-Inflammatory Activity Molecules <i>Heritiera</i> <i>Heritiera littoralis</i> heritiera C heritiera D anti-inflammatory |
| title | New Triterpenoids from the Leaves of <i>Heritiera littoralis</i> and Their Anti-Inflammatory Activity |
| title_full | New Triterpenoids from the Leaves of <i>Heritiera littoralis</i> and Their Anti-Inflammatory Activity |
| title_fullStr | New Triterpenoids from the Leaves of <i>Heritiera littoralis</i> and Their Anti-Inflammatory Activity |
| title_full_unstemmed | New Triterpenoids from the Leaves of <i>Heritiera littoralis</i> and Their Anti-Inflammatory Activity |
| title_short | New Triterpenoids from the Leaves of <i>Heritiera littoralis</i> and Their Anti-Inflammatory Activity |
| title_sort | new triterpenoids from the leaves of i heritiera littoralis i and their anti inflammatory activity |
| topic | <i>Heritiera</i> <i>Heritiera littoralis</i> heritiera C heritiera D anti-inflammatory |
| url | https://www.mdpi.com/1420-3049/30/1/131 |
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