Agranulocytosis induced by metamizole and its management with granulocyte growth factor
Drug-induced agranulocytosis was defined as a severe selective neutropenia caused by an unexpected drug reaction. Metamizole was the most common nonopioid analgesic drug associated with agranulocytosis. It was also associated with combined blood dyscrasias and other severe immunologic disorders. The...
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| Format: | Article |
| Language: | English |
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2005-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2005/0042-84500501079C.pdf |
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| _version_ | 1849407303572258816 |
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| author | Čeleketić Dušica Trpković Andreja Cvetković Zorica |
| author_facet | Čeleketić Dušica Trpković Andreja Cvetković Zorica |
| author_sort | Čeleketić Dušica |
| collection | DOAJ |
| description | Drug-induced agranulocytosis was defined as a severe selective neutropenia caused by an unexpected drug reaction. Metamizole was the most common nonopioid analgesic drug associated with agranulocytosis. It was also associated with combined blood dyscrasias and other severe immunologic disorders. The risk of agranulocytosis by metamizole seemed to be considerably higher than estimated formerly. Modern management with broad-spectrum antibiotics and haematopoietic growth factors reduced the mortality in those patients. Two cases of agranulocytosis caused by metamizole were reported. |
| format | Article |
| id | doaj-art-480a3e980e6344cab8635b3d34bc73f4 |
| institution | Kabale University |
| issn | 0042-8450 |
| language | English |
| publishDate | 2005-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-480a3e980e6344cab8635b3d34bc73f42025-08-20T03:36:07ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502005-01-01621798210.2298/VSP0501079CAgranulocytosis induced by metamizole and its management with granulocyte growth factorČeleketić DušicaTrpković AndrejaCvetković ZoricaDrug-induced agranulocytosis was defined as a severe selective neutropenia caused by an unexpected drug reaction. Metamizole was the most common nonopioid analgesic drug associated with agranulocytosis. It was also associated with combined blood dyscrasias and other severe immunologic disorders. The risk of agranulocytosis by metamizole seemed to be considerably higher than estimated formerly. Modern management with broad-spectrum antibiotics and haematopoietic growth factors reduced the mortality in those patients. Two cases of agranulocytosis caused by metamizole were reported.http://www.doiserbia.nb.rs/img/doi/0042-8450/2005/0042-84500501079C.pdfagranulocytosisdipyronegranulocyte colony-stimulating factor |
| spellingShingle | Čeleketić Dušica Trpković Andreja Cvetković Zorica Agranulocytosis induced by metamizole and its management with granulocyte growth factor Vojnosanitetski Pregled agranulocytosis dipyrone granulocyte colony-stimulating factor |
| title | Agranulocytosis induced by metamizole and its management with granulocyte growth factor |
| title_full | Agranulocytosis induced by metamizole and its management with granulocyte growth factor |
| title_fullStr | Agranulocytosis induced by metamizole and its management with granulocyte growth factor |
| title_full_unstemmed | Agranulocytosis induced by metamizole and its management with granulocyte growth factor |
| title_short | Agranulocytosis induced by metamizole and its management with granulocyte growth factor |
| title_sort | agranulocytosis induced by metamizole and its management with granulocyte growth factor |
| topic | agranulocytosis dipyrone granulocyte colony-stimulating factor |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2005/0042-84500501079C.pdf |
| work_keys_str_mv | AT celeketicdusica agranulocytosisinducedbymetamizoleanditsmanagementwithgranulocytegrowthfactor AT trpkovicandreja agranulocytosisinducedbymetamizoleanditsmanagementwithgranulocytegrowthfactor AT cvetkoviczorica agranulocytosisinducedbymetamizoleanditsmanagementwithgranulocytegrowthfactor |