The Influence of Different ECMO Cannulation Site and Blood Perfusion Conditions on the Aortic Hemodynamics: A Computational Fluid Dynamic Model
Extracorporeal Membrane Oxygenation (ECMO) is a medical device used to support patients with severe cardiac and/or respiratory failure. It is being used more frequently to offer percutaneous mechanical circulatory support, even though the intricate interactions between ECMO and the failing heart, as...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-11-01
|
| Series: | Fluids |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2311-5521/9/11/269 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850144867581165568 |
|---|---|
| author | Vera Gramigna Arrigo Palumbo Gionata Fragomeni |
| author_facet | Vera Gramigna Arrigo Palumbo Gionata Fragomeni |
| author_sort | Vera Gramigna |
| collection | DOAJ |
| description | Extracorporeal Membrane Oxygenation (ECMO) is a medical device used to support patients with severe cardiac and/or respiratory failure. It is being used more frequently to offer percutaneous mechanical circulatory support, even though the intricate interactions between ECMO and the failing heart, as well as its impact on hemodynamics and perfusion, are not yet fully understood. Within the two main types of ECMO support (the veno-venous ECMO (VV-ECMO), which is used to support only the lungs) and the veno-arterial ECMO (VA-ECMO), which is used to support the lungs and heart), consideration is given solely to the second approach. Indeed, this study focuses on the impact of different ECMO cannulation site and blood perfusion conditions on the aortic hemodynamics and organ perfusion in VA-ECMO. Using computed tomography (CT) images, we reconstructed specific aortic models based on clinical cannula configurations and placements. A detailed cannula-aorta integration model was developed to simulate the VA-ECMO blood supply environment. Employing computational fluid dynamics (CFD), we analyzed how varying ECMO perfusion levels and ECMO cannulation sites affect flow characteristics. This study provides insights into optimizing ECMO therapy by understanding its effects on blood flow and potential damage to blood and organs. |
| format | Article |
| id | doaj-art-4809662e7fd749498c9e6a73d9ea446e |
| institution | OA Journals |
| issn | 2311-5521 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Fluids |
| spelling | doaj-art-4809662e7fd749498c9e6a73d9ea446e2025-08-20T02:28:14ZengMDPI AGFluids2311-55212024-11-0191126910.3390/fluids9110269The Influence of Different ECMO Cannulation Site and Blood Perfusion Conditions on the Aortic Hemodynamics: A Computational Fluid Dynamic ModelVera Gramigna0Arrigo Palumbo1Gionata Fragomeni2Department of Medical and Surgical Sciences, University “Magna Graecia”, Viale Europa, 88100 Catanzaro, ItalyDepartment of Medical and Surgical Sciences, University “Magna Graecia”, Viale Europa, 88100 Catanzaro, ItalyDepartment of Medical and Surgical Sciences, University “Magna Graecia”, Viale Europa, 88100 Catanzaro, ItalyExtracorporeal Membrane Oxygenation (ECMO) is a medical device used to support patients with severe cardiac and/or respiratory failure. It is being used more frequently to offer percutaneous mechanical circulatory support, even though the intricate interactions between ECMO and the failing heart, as well as its impact on hemodynamics and perfusion, are not yet fully understood. Within the two main types of ECMO support (the veno-venous ECMO (VV-ECMO), which is used to support only the lungs) and the veno-arterial ECMO (VA-ECMO), which is used to support the lungs and heart), consideration is given solely to the second approach. Indeed, this study focuses on the impact of different ECMO cannulation site and blood perfusion conditions on the aortic hemodynamics and organ perfusion in VA-ECMO. Using computed tomography (CT) images, we reconstructed specific aortic models based on clinical cannula configurations and placements. A detailed cannula-aorta integration model was developed to simulate the VA-ECMO blood supply environment. Employing computational fluid dynamics (CFD), we analyzed how varying ECMO perfusion levels and ECMO cannulation sites affect flow characteristics. This study provides insights into optimizing ECMO therapy by understanding its effects on blood flow and potential damage to blood and organs.https://www.mdpi.com/2311-5521/9/11/269computational fluid dynamicsextracorporeal membrane oxygenationaortic hemodynamics |
| spellingShingle | Vera Gramigna Arrigo Palumbo Gionata Fragomeni The Influence of Different ECMO Cannulation Site and Blood Perfusion Conditions on the Aortic Hemodynamics: A Computational Fluid Dynamic Model Fluids computational fluid dynamics extracorporeal membrane oxygenation aortic hemodynamics |
| title | The Influence of Different ECMO Cannulation Site and Blood Perfusion Conditions on the Aortic Hemodynamics: A Computational Fluid Dynamic Model |
| title_full | The Influence of Different ECMO Cannulation Site and Blood Perfusion Conditions on the Aortic Hemodynamics: A Computational Fluid Dynamic Model |
| title_fullStr | The Influence of Different ECMO Cannulation Site and Blood Perfusion Conditions on the Aortic Hemodynamics: A Computational Fluid Dynamic Model |
| title_full_unstemmed | The Influence of Different ECMO Cannulation Site and Blood Perfusion Conditions on the Aortic Hemodynamics: A Computational Fluid Dynamic Model |
| title_short | The Influence of Different ECMO Cannulation Site and Blood Perfusion Conditions on the Aortic Hemodynamics: A Computational Fluid Dynamic Model |
| title_sort | influence of different ecmo cannulation site and blood perfusion conditions on the aortic hemodynamics a computational fluid dynamic model |
| topic | computational fluid dynamics extracorporeal membrane oxygenation aortic hemodynamics |
| url | https://www.mdpi.com/2311-5521/9/11/269 |
| work_keys_str_mv | AT veragramigna theinfluenceofdifferentecmocannulationsiteandbloodperfusionconditionsontheaortichemodynamicsacomputationalfluiddynamicmodel AT arrigopalumbo theinfluenceofdifferentecmocannulationsiteandbloodperfusionconditionsontheaortichemodynamicsacomputationalfluiddynamicmodel AT gionatafragomeni theinfluenceofdifferentecmocannulationsiteandbloodperfusionconditionsontheaortichemodynamicsacomputationalfluiddynamicmodel AT veragramigna influenceofdifferentecmocannulationsiteandbloodperfusionconditionsontheaortichemodynamicsacomputationalfluiddynamicmodel AT arrigopalumbo influenceofdifferentecmocannulationsiteandbloodperfusionconditionsontheaortichemodynamicsacomputationalfluiddynamicmodel AT gionatafragomeni influenceofdifferentecmocannulationsiteandbloodperfusionconditionsontheaortichemodynamicsacomputationalfluiddynamicmodel |