eEF-2K Deficiency Boosts the Virus-Specific Effector CD8<sup>+</sup> T Cell Responses During Viral Infection

eEF-2K Deficiency Boosts the Virus-Specific Effector CD8<sup>+</sup> T Cell Responses During Viral Infection

In this study, we revealed a critical role of eukaryotic elongation factor-2 kinase (eEF-2K), a negative regulator of protein synthesis, in regulating T cells during vaccinia virus (VACV) infection. We found that eEF-2K-deficient (eEF-2K⁻/⁻) mice exhibited a significantly higher proportion of VACV-s...

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Bibliographic Details
Main Authors: Liqing Wang, Benny Shone Song, Rayansh Poojary, Xiaofang Xiong, Xingcong Ren, Jin-Ming Yang, Jianxun Song
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Viruses
Subjects:
eEF-2K
effector CD8<sup>+</sup> T cells
vaccinia virus (VACV)
T cell immunity
TRAF3
viral infection
Online Access:https://www.mdpi.com/1999-4915/17/1/26
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