Doxorubicin synergizes bortezomib-induced multiple myeloma cell death by inhibiting aggresome formation and augmenting endoplasmic reticulum/Golgi stress and apoptosis

Doxorubicin synergizes bortezomib-induced multiple myeloma cell death by inhibiting aggresome formation and augmenting endoplasmic reticulum/Golgi stress and apoptosis

Abstract Background Bortezomib is a standard treatment for multiple myeloma (MM), working by the accumulation of toxic misfolded proteins in cancer cells. However, a significant clinical challenge arises from the development of resistance to bortezomib in MM treatment. Aggresome, a subcellular struc...

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Main Authors: Chang-Tze Ricky Yu, Yu-Ting Amber Liao, Chi-Yin Nina Chiang, Jo-Mei Maureen Chen, Hsin-Yu Bella Pan, Chia-Yun Pan, Wei-Jun Jiang, Jia-Rung Tsai, Tsung-Ying Yang, Chieh-Lin Jerry Teng
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Journal of Translational Medicine
Subjects:
Bortezomib
Doxorubicin
Multiple myeloma
Aggresome
Golgi stress
Online Access:https://doi.org/10.1186/s12967-024-05920-2
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