A case of unilateral focal choroidal excavation in Vogt-Koyanagi-Harada disease; case report
Purpose: To report a rare case of Vogt-Koyanagi-Harada (VKH) disease complicated by unilateral focal choroidal excavation (FCE). Methods: A 25-year-old male patient with bilateral blurred vision, tinnitus, and headache. Initial examination revealed multiple sensory retinal detachments in both eyes....
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Elsevier
2024-10-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024149286 |
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| author | Zhenbao Zhou Liying Zhao YuHuan Liu Nan Zhuo Han Chen ShouBi Wang YuYi Yang LiBo Wang XiangRu Zhou |
| author_facet | Zhenbao Zhou Liying Zhao YuHuan Liu Nan Zhuo Han Chen ShouBi Wang YuYi Yang LiBo Wang XiangRu Zhou |
| author_sort | Zhenbao Zhou |
| collection | DOAJ |
| description | Purpose: To report a rare case of Vogt-Koyanagi-Harada (VKH) disease complicated by unilateral focal choroidal excavation (FCE). Methods: A 25-year-old male patient with bilateral blurred vision, tinnitus, and headache. Initial examination revealed multiple sensory retinal detachments in both eyes. Optical coherence tomography (OCT), fundus fluorescein angiography (FFA), and other diagnostic tests confirmed VKH. The patient was treated with intravenous methylprednisolone followed by oral prednisolone. Results: Following treatment, the exudative retinal detachments resolved, and a subfoveal FCE was observed in the right eye. OCT imaging revealed choroidal inflammation and retinal pigment epithelium (RPE) disruption. The patient's visual acuity improved, but the FCE persisted during follow-up, suggesting a potential association between inflammation and the development of FCE in VKH. Conclusions: This case highlights the rare occurrence of FCE during the course of VKH disease, suggesting that inflammatory disruption of the RPE and choroidal atrophy may contribute to FCE formation. Comprehensive retinal imaging in VKH patients is essential for detecting such complications, which may influence long-term visual outcomes. This case adds to the limited literature on the relationship between ocular inflammation and choroidal excavation, providing valuable insights for future clinical management. |
| format | Article |
| id | doaj-art-47ff943950db49598b923521e6f802e7 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-47ff943950db49598b923521e6f802e72024-11-12T05:19:25ZengElsevierHeliyon2405-84402024-10-011020e38897A case of unilateral focal choroidal excavation in Vogt-Koyanagi-Harada disease; case reportZhenbao Zhou0Liying Zhao1YuHuan Liu2Nan Zhuo3Han Chen4ShouBi Wang5YuYi Yang6LiBo Wang7XiangRu Zhou8Department of Ophthalmology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Ophthalmology, HongQi Hospital, MuDanJiang Medical University, China; Corresponding author.Department of Ophthalmology, HuiGuang Aier Eye Hospital, ChinaDepartment of Ophthalmology, Traditional Chinese Medicine Hospital of Xiamen, ChinaDepartment of Ophthalmology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Ophthalmology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Ophthalmology, HuiGuang Aier Eye Hospital, ChinaDepartment of Ophthalmology, HuiGuang Aier Eye Hospital, ChinaDepartment of Ophthalmology, HongQi Hospital, MuDanJiang Medical University, ChinaPurpose: To report a rare case of Vogt-Koyanagi-Harada (VKH) disease complicated by unilateral focal choroidal excavation (FCE). Methods: A 25-year-old male patient with bilateral blurred vision, tinnitus, and headache. Initial examination revealed multiple sensory retinal detachments in both eyes. Optical coherence tomography (OCT), fundus fluorescein angiography (FFA), and other diagnostic tests confirmed VKH. The patient was treated with intravenous methylprednisolone followed by oral prednisolone. Results: Following treatment, the exudative retinal detachments resolved, and a subfoveal FCE was observed in the right eye. OCT imaging revealed choroidal inflammation and retinal pigment epithelium (RPE) disruption. The patient's visual acuity improved, but the FCE persisted during follow-up, suggesting a potential association between inflammation and the development of FCE in VKH. Conclusions: This case highlights the rare occurrence of FCE during the course of VKH disease, suggesting that inflammatory disruption of the RPE and choroidal atrophy may contribute to FCE formation. Comprehensive retinal imaging in VKH patients is essential for detecting such complications, which may influence long-term visual outcomes. This case adds to the limited literature on the relationship between ocular inflammation and choroidal excavation, providing valuable insights for future clinical management.http://www.sciencedirect.com/science/article/pii/S2405844024149286Focal choroidal excavation (FCE)Vogt–Koyanagi–Harada (VKH)Choroidal inflammationCase report |
| spellingShingle | Zhenbao Zhou Liying Zhao YuHuan Liu Nan Zhuo Han Chen ShouBi Wang YuYi Yang LiBo Wang XiangRu Zhou A case of unilateral focal choroidal excavation in Vogt-Koyanagi-Harada disease; case report Heliyon Focal choroidal excavation (FCE) Vogt–Koyanagi–Harada (VKH) Choroidal inflammation Case report |
| title | A case of unilateral focal choroidal excavation in Vogt-Koyanagi-Harada disease; case report |
| title_full | A case of unilateral focal choroidal excavation in Vogt-Koyanagi-Harada disease; case report |
| title_fullStr | A case of unilateral focal choroidal excavation in Vogt-Koyanagi-Harada disease; case report |
| title_full_unstemmed | A case of unilateral focal choroidal excavation in Vogt-Koyanagi-Harada disease; case report |
| title_short | A case of unilateral focal choroidal excavation in Vogt-Koyanagi-Harada disease; case report |
| title_sort | case of unilateral focal choroidal excavation in vogt koyanagi harada disease case report |
| topic | Focal choroidal excavation (FCE) Vogt–Koyanagi–Harada (VKH) Choroidal inflammation Case report |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024149286 |
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