Efficacy of ivabradine in patients with poor heart rate control after beta-blocker use in acute myocardial infarction: a pragmatic randomized controlled trial

Efficacy of ivabradine in patients with poor heart rate control after beta-blocker use in acute myocardial infarction: a pragmatic randomized controlled trial

IntroductionA rapid resting heart rate following acute myocardial infarction (AMI) predicts poor prognosis, making heart rate control crucial in treatment. Ivabradine is commonly used as a second-line therapy when beta-blockers are poorly tolerated. However, its efficacy in improving cardiac functio...

Full description

Saved in:

Bibliographic Details
Main Authors:	Yongbin Li, Ying Ren, Lisong Cheng, Xin Zhou, Wenting Li, Lingli Zhang, Jian Cui, Zhuhua Yao
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-04-01
Series:	Frontiers in Cardiovascular Medicine
Subjects:	ivabradine beta-blocker acute myocardial infarction heart rate real-world study pragmatic randomized controlled trial
Online Access:	https://www.frontiersin.org/articles/10.3389/fcvm.2025.1560639/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

IF CHANNEL INHIBITOR IVABRADINE AND CHRONIC HEART FAILURE MANAGEMENT: FROM DISCUSSION TO ACTION
by: Yu. M. Lopatin
Published: (2012-08-01)

Comparative efficacy of ivabradine and beta-blockers in the treatment of tachycardia in patients after COVID-19
by: V. I. Podzolkov, et al.
Published: (2022-08-01)

Heart rate-reducing agents ivabradine and beta-adrenoblockers in the management of patients with stable effort angina
by: Z. M. Galeeva, et al.
Published: (2011-02-01)

Beta blockers and their combinations in the management of hypertension
by: J.A. Ker
Published: (2012-10-01)

Possibilities of Combination of Beta-blockers and Ivabradine in Patients with Stable Angina Pectoris
by: V. V. Kashtalap, et al.
Published: (2019-11-01)

Beta-blockers in modern glaucoma therapy. Review
by: O. A. Kiseleva, et al.
Published: (2014-07-01)

Comparative study between oral and intralesional injection of beta-blocker in the treatment of infantile capillary hemangioma
by: Sahar S Sheta, et al.
Published: (2025-07-01)

Continuation vs Withdrawal of Beta-Blockers and Outcomes After Myocardial Infarction With Preserved Left Ventricular Function
by: Michael H. Chiu, MD, MSc, et al.
Published: (2025-06-01)

PRACTICE OF PRESCRIBING BETA-BLOCKERS AND ITS COMPLIANCE WITH CLINICAL GUIDELINES ACCORDING TO TWO REGISTERS OF CARDIOVASCULAR DISEASES
by: S. Yu. Martsevich, et al.
Published: (2016-06-01)

THE ROLE OF VASODILATING BETA-BLOCKERS IN PATIENTS WITH HYPERTENSION AND THE CARDIOMETABOLIC SYNDROME
by: A. A. Taylor, et al.
Published: (2011-08-01)

Combined use of beta-blockers and non-dihydropyridine calcium channel blockers: possible or contraindicated?
by: S. S. Yakushin, et al.
Published: (2024-02-01)

Successful treatment with ivabradine in a β‐blocker‐refractory patient with acute decompensated heart failure with reduced ejection fraction
by: Tomoko Inoue, et al.
Published: (2023-03-01)

Use of Beta-Blockers as a First-Line Treatment for Primary Hypertension
by: Maryam Izadi, et al.
Published: (2024-10-01)

Heart rate-lowering antianginal medications: what determines their choice?
by: Yu. M. Lopatin
Published: (1970-01-01)

THE BISOPROLOL — A HIGH SELECTIVE BETA-BLOCKER ACCORDING TO EVIDENCE BASED MEDICINE
by: Yu. V. Lukina, et al.
Published: (2016-01-01)

USE OF BETA-BLOCKERS IN THE PERIOPERATIVE PERIOD: HOW STRONG ARE THE EVIDENCES?
by: V. V. Samoylenko, et al.
Published: (2015-09-01)

WHY BETA-BLOCKERS ARE NOT PRESCRIBED TO PATIENTS WITH HEART FAILURE AND HOW TO IMPROVE IT?
by: S. N. Tereshchenko, et al.
Published: (2016-01-01)

Beta-blockers in Cardiovascular Therapy: A Review
by: Camelia C. Diaconu, et al.
Published: (2019-10-01)

Review: Investigation of the electrochemical properties of beta blockers and ACE inhibitors by cyclic voltammetry
by: Edhem Hasković, et al.
Published: (2020-06-01)

Off-Label Explorations: Beta Blockers Misuse among University Students in Jordan
by: Layla Nazzal, et al.
Published: (2025-05-01)

Experience of using topical beta-blockers in combination therapy of rosacea
by: Inna V. Il`ina, et al.
Published: (2025-01-01)

PENGARUH PENGGUNAAN BETA BLOCKER TOPIKAL JANGKA PANJANG TERHADAP SENSIBILITAS KORNEA PADA PASIEN GLAUKOMA
by: Tusita Devi, et al.
Published: (2017-06-01)

IVABRADIN AND ATENOLOL EFFECTIVENESS COMPARISON IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY
by: P. Kh. Dzhanashiya, et al.
Published: (2010-02-01)

THE CHOICE OF DRUG FROM THE STANDPOINT OF EVIDENCE-BASED MEDICINE: CASE STUDY OF BETA-BLOCKERS
by: S. Yu. Martsevich, et al.
Published: (2016-01-01)

Effectiveness of a selective If channel inhibitor ivabradine in patients with stable angina
by: E. V. Kuleshova
Published: (2009-10-01)

Effectiveness of beta-blockers in the treatment of idiopathic premature ventricular contractions in children
by: K. B. Alekseeva, et al.
Published: (2022-08-01)

IVABRADINE OUTSIDE THE CLINICAL GUIDELINES: INTEREST OF A PRACTITIONER
by: E. I. Tarlovskaya
Published: (2018-04-01)

Beta-blocker and calcium-channel blocker therapy in patients with cardiovascular pathologies during post-COVID period
by: A. G. Arutyunov, et al.
Published: (2022-01-01)

Persistent Beta‐Blocker Therapy Reduces Long‐Term Mortality in Patients With Acute Ischemic Stroke With Elevated Heart Rates
by: Keon‐Joo Lee, et al.
Published: (2025-03-01)

Ivabradine therapy and correction of the target organ pathology in patients with ischemic chronic heart failure
by: M. V. Surovtseva, et al.
Published: (2013-06-01)

Pre‐admission beta‐blocker therapy and outcomes in cardiogenic shock: Insights from the Altshock‐2 Registry
by: Matteo Pagnesi, et al.
Published: (2025-08-01)

Association between beta‐blocker atenolol use and prostate cancer upgrading in active surveillance1
by: Ali H. Zahalka, et al.
Published: (2024-11-01)

ENDOTHELIAL DYSFUNCTION AND ROLE NITRATES AND BETA-BLOCKERS IN ITS CORRECTION IN ISCHEMIC HEART DISEASE
by: A. N. Britov
Published: (2016-05-01)

Antianginal effectiveness and tolerability of ivabradine in patients with stable angina: CONTROL-2 Study results
by: Yu. A. Karpov, et al.
Published: (1970-01-01)

Effect of maternal beta-blocker treatment on mean fetal heart rateAJOG Global Reports at a Glance
by: Sarah Hautier, MD, et al.
Published: (2025-02-01)

Impact of Beta-Blockers on Pneumonia, Mortality and Functional Outcomes of Patients with Intracerebral Hemorrhage-A Retrospective Multicenter Study
by: Gao B, et al.
Published: (2025-07-01)

The Effectiveness of Liquid-Phase Microextraction of Beta-Blockers from Aqueous Matrices for Their Analysis by Chromatographic Techniques
by: Mihail Simion Beldean-Galea, et al.
Published: (2025-02-01)

Beta blocker use and breast cancer survival by subtypes: A population-based cohort study
by: Oliver William Scott, et al.
Published: (2025-06-01)

Peculiarities of Adverse Events Manifested by Injury of Skin and Skin Derivatives and Associated with Beta-blockers Use
by: A. V. Matveev, et al.
Published: (2021-11-01)

Selective If-channel inhibitor ivabradine in the treatment of sinus tachycardia in coronary heart disease patients with acute heart failure and inferior myocardial infarction
by: S. A. Sayganov, et al.
Published: (2010-06-01)