Secondary Hyperparathyroidism and Bone Turnover in Elderly with Bone Loss - Original Investigation
Bone loss is common in the elderly. Parathyroid hormone (PTH), which regulates serum calcium levels,calcitonin and vitamin D metabolites have various effects on skeletal system. The aim of this study was to assess secondary hyperparathyroidism (HPTH) and bone turnover in elderly with bone loss. Fif...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2006-12-01
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| Series: | Türk Osteoporoz Dergisi |
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| Online Access: | http://www.turkosteoporozdergisi.org/article_4143/Secondary-Hyperparathyroidism-And-Bone-Turnover-In-Elderly-With-Bone-Loss-Original-Investigation |
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| _version_ | 1849407300536631296 |
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| author | Nurdan Peker Demet Tekdöş Metin Erbil Betül Kaya Çağlayan Dere |
| author_facet | Nurdan Peker Demet Tekdöş Metin Erbil Betül Kaya Çağlayan Dere |
| author_sort | Nurdan Peker |
| collection | DOAJ |
| description | Bone loss is common in the elderly. Parathyroid hormone (PTH), which regulates serum calcium levels,calcitonin and vitamin D metabolites have various effects on skeletal system. The aim of this study was to assess secondary hyperparathyroidism (HPTH) and bone turnover in elderly with bone loss.
Fifty-five patients (9 men,46 women) older than 65 years with bone loss were included in the study. Bone mineral density was measured by dual energy x-ray absorptiomety (DXA) at L1-4 vertebrae and proximal femur regions. Patients with T scores <-1.5 at one of the measurement sites were included in the study. Study subjects were assessed in terms of fracture history, sunbathing and walking activity. Routine biochemical tests, serum osteocalcin (OC) and C-telopeptide type 1 collagen (CTX) and lateral thoracal and lumbar vertebrae radyographic evaluation was performed. Our results showed that 70.9% of the patients had HPTH. Total femur BMD values and femur neck T scores were significantly lower in HPTH group than PTH normal one (p=0.05, p=0.03). Serum OC and CTX levels were higher in both groups. There was a negative correlation with femur neck BMD and CTX (r=0,321).
There was no correlation between serum PTH levels and lumbar vertebrae and proximal femur BMD values. Serum PTH and alkaline phosphatase levels showed a significant positive correlation.
In conclusion secondary HPTH and increased bone turnover is common elderly with bone loss. Adequate calcium and vitamin D intake is important the older people. (Osteoporoz Dünyasından 2006; 12: 70-3) |
| format | Article |
| id | doaj-art-47fede3fe1284f4ba9281b6839c09e4b |
| institution | Kabale University |
| issn | 2147-2653 |
| language | English |
| publishDate | 2006-12-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Türk Osteoporoz Dergisi |
| spelling | doaj-art-47fede3fe1284f4ba9281b6839c09e4b2025-08-20T03:36:07ZengGalenos Publishing HouseTürk Osteoporoz Dergisi2147-26532006-12-011247073Secondary Hyperparathyroidism and Bone Turnover in Elderly with Bone Loss - Original InvestigationNurdan Peker0Demet Tekdöş1Metin Erbil2Betül Kaya3Çağlayan Dere4İstanbul 70. Yıl Fizik Tedavi ve Rehabilitasyon Eğitim ve Araştırma Hastanesi, İstanbul, Türkiyeİstanbul 70. Yıl Fizik Tedavi ve Rehabilitasyon Eğitim ve Araştırma Hastanesi, İstanbul, Türkiyeİstanbul 70. Yıl Fizik Tedavi ve Rehabilitasyon Eğitim ve Araştırma Hastanesi, İstanbul, Türkiyeİstanbul 70. Yıl Fizik Tedavi ve Rehabilitasyon Eğitim ve Araştırma Hastanesi, İstanbul, Türkiyeİstanbul 70. Yıl Fizik Tedavi ve Rehabilitasyon Eğitim ve Araştırma Hastanesi, İstanbul, TürkiyeBone loss is common in the elderly. Parathyroid hormone (PTH), which regulates serum calcium levels,calcitonin and vitamin D metabolites have various effects on skeletal system. The aim of this study was to assess secondary hyperparathyroidism (HPTH) and bone turnover in elderly with bone loss. Fifty-five patients (9 men,46 women) older than 65 years with bone loss were included in the study. Bone mineral density was measured by dual energy x-ray absorptiomety (DXA) at L1-4 vertebrae and proximal femur regions. Patients with T scores <-1.5 at one of the measurement sites were included in the study. Study subjects were assessed in terms of fracture history, sunbathing and walking activity. Routine biochemical tests, serum osteocalcin (OC) and C-telopeptide type 1 collagen (CTX) and lateral thoracal and lumbar vertebrae radyographic evaluation was performed. Our results showed that 70.9% of the patients had HPTH. Total femur BMD values and femur neck T scores were significantly lower in HPTH group than PTH normal one (p=0.05, p=0.03). Serum OC and CTX levels were higher in both groups. There was a negative correlation with femur neck BMD and CTX (r=0,321). There was no correlation between serum PTH levels and lumbar vertebrae and proximal femur BMD values. Serum PTH and alkaline phosphatase levels showed a significant positive correlation. In conclusion secondary HPTH and increased bone turnover is common elderly with bone loss. Adequate calcium and vitamin D intake is important the older people. (Osteoporoz Dünyasından 2006; 12: 70-3)http://www.turkosteoporozdergisi.org/article_4143/Secondary-Hyperparathyroidism-And-Bone-Turnover-In-Elderly-With-Bone-Loss-Original-InvestigationParathormonebone turnoverdual energy x ray absorbsiometryosteocalcinC-telopeptide type 1 collagen |
| spellingShingle | Nurdan Peker Demet Tekdöş Metin Erbil Betül Kaya Çağlayan Dere Secondary Hyperparathyroidism and Bone Turnover in Elderly with Bone Loss - Original Investigation Türk Osteoporoz Dergisi Parathormone bone turnover dual energy x ray absorbsiometry osteocalcin C-telopeptide type 1 collagen |
| title | Secondary Hyperparathyroidism and Bone Turnover in Elderly with Bone Loss - Original Investigation |
| title_full | Secondary Hyperparathyroidism and Bone Turnover in Elderly with Bone Loss - Original Investigation |
| title_fullStr | Secondary Hyperparathyroidism and Bone Turnover in Elderly with Bone Loss - Original Investigation |
| title_full_unstemmed | Secondary Hyperparathyroidism and Bone Turnover in Elderly with Bone Loss - Original Investigation |
| title_short | Secondary Hyperparathyroidism and Bone Turnover in Elderly with Bone Loss - Original Investigation |
| title_sort | secondary hyperparathyroidism and bone turnover in elderly with bone loss original investigation |
| topic | Parathormone bone turnover dual energy x ray absorbsiometry osteocalcin C-telopeptide type 1 collagen |
| url | http://www.turkosteoporozdergisi.org/article_4143/Secondary-Hyperparathyroidism-And-Bone-Turnover-In-Elderly-With-Bone-Loss-Original-Investigation |
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