C-reactive protein-to-prealbumin ratio as prognostic marker in hemodialysis patients with Omicron infection
Background Hemodialysis patients frequently experience chronic inflammation and malnutrition, while C-reactive protein to prealbumin ratio (CP ratio) is a comprehensive assessment approach of inflammatory and nutritional status. Howerer, there is limited research on the prognostic value of the CP ra...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2025.2512404 |
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| author | Quanchao Zhang Caibao Lu Zhifen Wu Shaofa Wu Lili Jiang Han Wang Jin He Bingshuang Tang Bingfeng Yang Shengli Liao Liao Wang Hongwei Chen Moqi Li Wenchang He Yiqin Wang Jie Li Jinghong Zhao Ling Nie |
| author_facet | Quanchao Zhang Caibao Lu Zhifen Wu Shaofa Wu Lili Jiang Han Wang Jin He Bingshuang Tang Bingfeng Yang Shengli Liao Liao Wang Hongwei Chen Moqi Li Wenchang He Yiqin Wang Jie Li Jinghong Zhao Ling Nie |
| author_sort | Quanchao Zhang |
| collection | DOAJ |
| description | Background Hemodialysis patients frequently experience chronic inflammation and malnutrition, while C-reactive protein to prealbumin ratio (CP ratio) is a comprehensive assessment approach of inflammatory and nutritional status. Howerer, there is limited research on the prognostic value of the CP ratio specifically in hemodialysis patients infected with the Omicron variant.Methods Data from 847 hemodialysis patients, diagnosed with Omicron across 6 hemodialysis centers between December 2022 and February 2023, were analyzed. Hazard ratios were estimated using univariate and multivariable Cox regression, and receiver operating characteristic curves were used to evaluate the predictive abilities. Survival rate differences between higher and lower CP ratio groups were analyzed using the Kaplan-Meier method.Results From the total, 98 patients (11.6%) succumbed, with a majority (80/98) within a month post-infection. C-reactive protein, prealbumin, and CP ratio were all associated with all-cause mortality in the crude model. After adjusting for other confounding factors, the CP ratio remained an independent risk factor for all-cause mortality (HR 1.97; 95% CI 1.07–3.63; p = 0.029). In addition, we also found that the CP ratio has better discriminatory ability, than the C-reactive protein to albumin ratio (areas under the curve; 0.84 vs. 0.80; Z-test; p = 0.001).Conclusions This study underscores that CP ratio substantially influence the mortality rates in hemodialysis patients following Omicron infection. Careful monitoring and consideration of the CP ratio could inform more effective patient management strategies, potentially leading to reduced mortality rates in this vulnerable group. |
| format | Article |
| id | doaj-art-47f968192fba4337a6d959c8df9fb472 |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-47f968192fba4337a6d959c8df9fb4722025-08-20T03:47:21ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492025-12-0147110.1080/0886022X.2025.2512404C-reactive protein-to-prealbumin ratio as prognostic marker in hemodialysis patients with Omicron infectionQuanchao Zhang0Caibao Lu1Zhifen Wu2Shaofa Wu3Lili Jiang4Han Wang5Jin He6Bingshuang Tang7Bingfeng Yang8Shengli Liao9Liao Wang10Hongwei Chen11Moqi Li12Wenchang He13Yiqin Wang14Jie Li15Jinghong Zhao16Ling Nie17Department of Nephrology, the Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing, Chongqing Clinical Research Center of Kidney and Urology Diseases, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, ChinaDepartment of Nephrology, the Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing, Chongqing Clinical Research Center of Kidney and Urology Diseases, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, ChinaUrology and Kidney Disease Center, Yongchuan People’s Hospital of Chongqing, Chongqing, ChinaDepartment of Nephrology, Youyang Hospital, A Branch of the First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Nephrology, Youyang Hospital, A Branch of the First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Endocrinology and Nephrology, Chongqing General Hospital, Chongqing, ChinaDepartment of Endocrinology and Nephrology, Chongqing General Hospital, Chongqing, ChinaDepartment of Nephrology and Endocrinology, ChongQingBishan District Hospital of Traditional Chinese Medicine, Chongqing, ChinaDepartment of Nephrology and Endocrinology, ChongQingBishan District Hospital of Traditional Chinese Medicine, Chongqing, ChinaHemodialysis Center of Nanchuan Hospital of Traditional Chinese Medicine, Chongqing, ChinaHemodialysis Center of Nanchuan Hospital of Traditional Chinese Medicine, Chongqing, ChinaDepartment of Nephrology, the Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing, Chongqing Clinical Research Center of Kidney and Urology Diseases, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, ChinaDepartment of Nephrology, the Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing, Chongqing Clinical Research Center of Kidney and Urology Diseases, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, ChinaDepartment of Nephrology, the Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing, Chongqing Clinical Research Center of Kidney and Urology Diseases, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, ChinaDepartment of Nephrology, the Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing, Chongqing Clinical Research Center of Kidney and Urology Diseases, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, ChinaUrology and Kidney Disease Center, Yongchuan People’s Hospital of Chongqing, Chongqing, ChinaDepartment of Nephrology, the Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing, Chongqing Clinical Research Center of Kidney and Urology Diseases, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, ChinaDepartment of Nephrology, the Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing, Chongqing Clinical Research Center of Kidney and Urology Diseases, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, ChinaBackground Hemodialysis patients frequently experience chronic inflammation and malnutrition, while C-reactive protein to prealbumin ratio (CP ratio) is a comprehensive assessment approach of inflammatory and nutritional status. Howerer, there is limited research on the prognostic value of the CP ratio specifically in hemodialysis patients infected with the Omicron variant.Methods Data from 847 hemodialysis patients, diagnosed with Omicron across 6 hemodialysis centers between December 2022 and February 2023, were analyzed. Hazard ratios were estimated using univariate and multivariable Cox regression, and receiver operating characteristic curves were used to evaluate the predictive abilities. Survival rate differences between higher and lower CP ratio groups were analyzed using the Kaplan-Meier method.Results From the total, 98 patients (11.6%) succumbed, with a majority (80/98) within a month post-infection. C-reactive protein, prealbumin, and CP ratio were all associated with all-cause mortality in the crude model. After adjusting for other confounding factors, the CP ratio remained an independent risk factor for all-cause mortality (HR 1.97; 95% CI 1.07–3.63; p = 0.029). In addition, we also found that the CP ratio has better discriminatory ability, than the C-reactive protein to albumin ratio (areas under the curve; 0.84 vs. 0.80; Z-test; p = 0.001).Conclusions This study underscores that CP ratio substantially influence the mortality rates in hemodialysis patients following Omicron infection. Careful monitoring and consideration of the CP ratio could inform more effective patient management strategies, potentially leading to reduced mortality rates in this vulnerable group.https://www.tandfonline.com/doi/10.1080/0886022X.2025.2512404HemodialysisomicronC-reactive protein to prealbumin ratiomortality |
| spellingShingle | Quanchao Zhang Caibao Lu Zhifen Wu Shaofa Wu Lili Jiang Han Wang Jin He Bingshuang Tang Bingfeng Yang Shengli Liao Liao Wang Hongwei Chen Moqi Li Wenchang He Yiqin Wang Jie Li Jinghong Zhao Ling Nie C-reactive protein-to-prealbumin ratio as prognostic marker in hemodialysis patients with Omicron infection Renal Failure Hemodialysis omicron C-reactive protein to prealbumin ratio mortality |
| title | C-reactive protein-to-prealbumin ratio as prognostic marker in hemodialysis patients with Omicron infection |
| title_full | C-reactive protein-to-prealbumin ratio as prognostic marker in hemodialysis patients with Omicron infection |
| title_fullStr | C-reactive protein-to-prealbumin ratio as prognostic marker in hemodialysis patients with Omicron infection |
| title_full_unstemmed | C-reactive protein-to-prealbumin ratio as prognostic marker in hemodialysis patients with Omicron infection |
| title_short | C-reactive protein-to-prealbumin ratio as prognostic marker in hemodialysis patients with Omicron infection |
| title_sort | c reactive protein to prealbumin ratio as prognostic marker in hemodialysis patients with omicron infection |
| topic | Hemodialysis omicron C-reactive protein to prealbumin ratio mortality |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2025.2512404 |
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