Clinical characteristics of 30 children with severe acute SARS‐CoV‐2 infection
Abstract Background To describe the characteristics of pediatric patients with severe COVID‐19 in China and identify the clinical variables associated with cardiovascular involvement, severe neurological complications, and disease prognosis. Methods A retrospective surveillance study were conducted...
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| Format: | Article |
| Language: | English |
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Wiley
2024-12-01
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| Series: | Hong Kong Journal of Emergency Medicine |
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| Online Access: | https://doi.org/10.1002/hkj2.12043 |
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| author | Weijun Li Danping Zhu Weiqiang Xiao Defeng Liang Huarong Deng Jipeng Zheng Qiang Wang Guangming Liu Peiqing Li |
| author_facet | Weijun Li Danping Zhu Weiqiang Xiao Defeng Liang Huarong Deng Jipeng Zheng Qiang Wang Guangming Liu Peiqing Li |
| author_sort | Weijun Li |
| collection | DOAJ |
| description | Abstract Background To describe the characteristics of pediatric patients with severe COVID‐19 in China and identify the clinical variables associated with cardiovascular involvement, severe neurological complications, and disease prognosis. Methods A retrospective surveillance study were conducted from December 1 to 31, 2022, in Guangzhou Women and Children's Medical Center. Clinical and laboratory characteristics were abstracted by medical record review and were further analyzed according to different manifestations. Results A total of 30 children (median age, 27.5 months; 36.7% female) met the criteria for the diagnosis of severe COVID‐19. The top five presented symptoms were fever, convulsions, cough, polypnea, and fatigue. Compared with shock absent patients, the cardiovascular involved patients had different laboratory features, including elevated aspartate aminotransferase (AST), lactic acid levels, and abnormalities in coagulation parameters. Higher levels of alanine aminotransferase, AST, lactic dehydrogenase, creatinine, lactic acid, and abnormal coagulant function were more common in patients with severe neurological complications and patients who died during hospitalization. Higher lymphocyte counts and serum sodium concentrations were also observed in non‐survivors. Conclusion Severe COVID‐19 pediatric patients had varied clinical characteristics. Laboratory features associated with cardiovascular involvement, severe neurological complications, and adverse outcomes may facilitate early identification of the severe patients. |
| format | Article |
| id | doaj-art-47e9bbea822e4dd08ee8d1e8aee603f6 |
| institution | OA Journals |
| issn | 1024-9079 2309-5407 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Hong Kong Journal of Emergency Medicine |
| spelling | doaj-art-47e9bbea822e4dd08ee8d1e8aee603f62025-08-20T01:57:15ZengWileyHong Kong Journal of Emergency Medicine1024-90792309-54072024-12-0131628529810.1002/hkj2.12043Clinical characteristics of 30 children with severe acute SARS‐CoV‐2 infectionWeijun Li0Danping Zhu1Weiqiang Xiao2Defeng Liang3Huarong Deng4Jipeng Zheng5Qiang Wang6Guangming Liu7Peiqing Li8Pediatric Emergency Department Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangdong Provincial Clinical Research Center for Child Health Guangzhou ChinaPediatric Emergency Department Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangdong Provincial Clinical Research Center for Child Health Guangzhou ChinaDepartment of Pediatric Radiology Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangdong Provincial Clinical Research Center for Child Health Guangzhou ChinaPediatric Emergency Department Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangdong Provincial Clinical Research Center for Child Health Guangzhou ChinaPediatric Emergency Department Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangdong Provincial Clinical Research Center for Child Health Guangzhou ChinaPediatric Emergency Department Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangdong Provincial Clinical Research Center for Child Health Guangzhou ChinaPediatric Emergency Department Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangdong Provincial Clinical Research Center for Child Health Guangzhou ChinaPediatric Emergency Department Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangdong Provincial Clinical Research Center for Child Health Guangzhou ChinaPediatric Emergency Department Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangdong Provincial Clinical Research Center for Child Health Guangzhou ChinaAbstract Background To describe the characteristics of pediatric patients with severe COVID‐19 in China and identify the clinical variables associated with cardiovascular involvement, severe neurological complications, and disease prognosis. Methods A retrospective surveillance study were conducted from December 1 to 31, 2022, in Guangzhou Women and Children's Medical Center. Clinical and laboratory characteristics were abstracted by medical record review and were further analyzed according to different manifestations. Results A total of 30 children (median age, 27.5 months; 36.7% female) met the criteria for the diagnosis of severe COVID‐19. The top five presented symptoms were fever, convulsions, cough, polypnea, and fatigue. Compared with shock absent patients, the cardiovascular involved patients had different laboratory features, including elevated aspartate aminotransferase (AST), lactic acid levels, and abnormalities in coagulation parameters. Higher levels of alanine aminotransferase, AST, lactic dehydrogenase, creatinine, lactic acid, and abnormal coagulant function were more common in patients with severe neurological complications and patients who died during hospitalization. Higher lymphocyte counts and serum sodium concentrations were also observed in non‐survivors. Conclusion Severe COVID‐19 pediatric patients had varied clinical characteristics. Laboratory features associated with cardiovascular involvement, severe neurological complications, and adverse outcomes may facilitate early identification of the severe patients.https://doi.org/10.1002/hkj2.12043childCOVID‐19neurological involvementSARS‐CoV‐2shock |
| spellingShingle | Weijun Li Danping Zhu Weiqiang Xiao Defeng Liang Huarong Deng Jipeng Zheng Qiang Wang Guangming Liu Peiqing Li Clinical characteristics of 30 children with severe acute SARS‐CoV‐2 infection Hong Kong Journal of Emergency Medicine child COVID‐19 neurological involvement SARS‐CoV‐2 shock |
| title | Clinical characteristics of 30 children with severe acute SARS‐CoV‐2 infection |
| title_full | Clinical characteristics of 30 children with severe acute SARS‐CoV‐2 infection |
| title_fullStr | Clinical characteristics of 30 children with severe acute SARS‐CoV‐2 infection |
| title_full_unstemmed | Clinical characteristics of 30 children with severe acute SARS‐CoV‐2 infection |
| title_short | Clinical characteristics of 30 children with severe acute SARS‐CoV‐2 infection |
| title_sort | clinical characteristics of 30 children with severe acute sars cov 2 infection |
| topic | child COVID‐19 neurological involvement SARS‐CoV‐2 shock |
| url | https://doi.org/10.1002/hkj2.12043 |
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