Mitochondrial Quality Control Orchestrates the Symphony of B Cells and Plays Critical Roles in B Cell-Related Diseases
B cells are essential for humoral immune response due to their ability to secrete antibodies. The development of B cells from the bone marrow to the periphery is tightly regulated by a complex set of immune signals, and each subset of B cells has a unique metabolic profile. Mitochondria, which serve...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2024/5577506 |
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| author | Wuhao Li Peiyang Cai Ye Xu Weihong Tian Licong Jing Qiaoyi Lv Yangjing Zhao Hui Wang Qixiang Shao |
| author_facet | Wuhao Li Peiyang Cai Ye Xu Weihong Tian Licong Jing Qiaoyi Lv Yangjing Zhao Hui Wang Qixiang Shao |
| author_sort | Wuhao Li |
| collection | DOAJ |
| description | B cells are essential for humoral immune response due to their ability to secrete antibodies. The development of B cells from the bone marrow to the periphery is tightly regulated by a complex set of immune signals, and each subset of B cells has a unique metabolic profile. Mitochondria, which serve as cellular energy powerhouses, play an essential role in regulating cell survival and immune responses. To maintain metabolic homeostasis, mitochondria dynamically adjust their morphology, distribution, and mass via biogenesis, fusion and fission, translocation, and mitophagy. Despite its extreme importance, the role of mitochondrial quality control (MQC) in B cells has not been thoroughly summarized, unlike in T cells. This article aims to review the mechanism of MQC that shapes B cell fate and functions. In addition, we will discuss the physiological and pathological implications of MQC in B cells, providing new insights into potential therapeutic targets for diseases associated with B cell abnormalities. |
| format | Article |
| id | doaj-art-47e6e97ddc5d49439aa5c725cfbea342 |
| institution | Kabale University |
| issn | 2314-7156 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-47e6e97ddc5d49439aa5c725cfbea3422025-02-03T01:40:58ZengWileyJournal of Immunology Research2314-71562024-01-01202410.1155/2024/5577506Mitochondrial Quality Control Orchestrates the Symphony of B Cells and Plays Critical Roles in B Cell-Related DiseasesWuhao Li0Peiyang Cai1Ye Xu2Weihong Tian3Licong Jing4Qiaoyi Lv5Yangjing Zhao6Hui Wang7Qixiang Shao8Jiangsu Key Laboratory of Medical Science and Laboratory MedicineJiangsu Key Laboratory of Medical Science and Laboratory MedicineJiangsu Key Laboratory of Medical Science and Laboratory MedicineJiangsu Key Laboratory of Medical Science and Laboratory MedicineJiangsu Key Laboratory of Medical Science and Laboratory MedicineJiangsu Key Laboratory of Medical Science and Laboratory MedicineJiangsu Key Laboratory of Medical Science and Laboratory MedicineJiangsu Key Laboratory of Medical Science and Laboratory MedicineJiangsu Key Laboratory of Medical Science and Laboratory MedicineB cells are essential for humoral immune response due to their ability to secrete antibodies. The development of B cells from the bone marrow to the periphery is tightly regulated by a complex set of immune signals, and each subset of B cells has a unique metabolic profile. Mitochondria, which serve as cellular energy powerhouses, play an essential role in regulating cell survival and immune responses. To maintain metabolic homeostasis, mitochondria dynamically adjust their morphology, distribution, and mass via biogenesis, fusion and fission, translocation, and mitophagy. Despite its extreme importance, the role of mitochondrial quality control (MQC) in B cells has not been thoroughly summarized, unlike in T cells. This article aims to review the mechanism of MQC that shapes B cell fate and functions. In addition, we will discuss the physiological and pathological implications of MQC in B cells, providing new insights into potential therapeutic targets for diseases associated with B cell abnormalities.http://dx.doi.org/10.1155/2024/5577506 |
| spellingShingle | Wuhao Li Peiyang Cai Ye Xu Weihong Tian Licong Jing Qiaoyi Lv Yangjing Zhao Hui Wang Qixiang Shao Mitochondrial Quality Control Orchestrates the Symphony of B Cells and Plays Critical Roles in B Cell-Related Diseases Journal of Immunology Research |
| title | Mitochondrial Quality Control Orchestrates the Symphony of B Cells and Plays Critical Roles in B Cell-Related Diseases |
| title_full | Mitochondrial Quality Control Orchestrates the Symphony of B Cells and Plays Critical Roles in B Cell-Related Diseases |
| title_fullStr | Mitochondrial Quality Control Orchestrates the Symphony of B Cells and Plays Critical Roles in B Cell-Related Diseases |
| title_full_unstemmed | Mitochondrial Quality Control Orchestrates the Symphony of B Cells and Plays Critical Roles in B Cell-Related Diseases |
| title_short | Mitochondrial Quality Control Orchestrates the Symphony of B Cells and Plays Critical Roles in B Cell-Related Diseases |
| title_sort | mitochondrial quality control orchestrates the symphony of b cells and plays critical roles in b cell related diseases |
| url | http://dx.doi.org/10.1155/2024/5577506 |
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