A Higher Fructose Intake Is Associated with Greater Albuminuria in Subjects with Type 2 Diabetes Mellitus
The aim of this single center cross-sectional study was to investigate the association between fructose intake and albuminuria in subjects with type 2 diabetes mellitus (T2DM). This is a single center cross-sectional study. One hundred and forty-three subjects with T2DM were recruited from the Insti...
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2018-01-01
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| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2018/5459439 |
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| author | Miguel Ángel Gómez-Sámano Paloma Almeda-Valdes Daniel Cuevas-Ramos María Fernanda Navarro-Flores Héctor Donaldo Espinosa-Salazar Mayela Martínez-Saavedra Jefsi Argelia León-Domínguez Víctor Manuel Enríquez-Estrada Ana Laura López-González Ana Laura Sarmiento-Moreno Lucero Alejandra Rivera-González Óscar Alfredo Juárez-León Bernardo Pérez-González Yessica Ávila-Palacios Lineth Sigala-Pedroza Eira Huerta-Ávila María Angelina Vargas-Álvarez Carlos Sánchez-Jaimes Mariana Cárdenas-Vera Roopa Mehta Manuel Alejandro López-Flores A La Torre Iliana Manjarrez-Martínez Griselda Xochitl Brito-Córdova Julia M. Zuarth-Vázquez Arturo Vega-Beyhart Guadalupe López-Carrasco Richard J. Johnson Francisco Javier Gómez-Pérez |
| author_facet | Miguel Ángel Gómez-Sámano Paloma Almeda-Valdes Daniel Cuevas-Ramos María Fernanda Navarro-Flores Héctor Donaldo Espinosa-Salazar Mayela Martínez-Saavedra Jefsi Argelia León-Domínguez Víctor Manuel Enríquez-Estrada Ana Laura López-González Ana Laura Sarmiento-Moreno Lucero Alejandra Rivera-González Óscar Alfredo Juárez-León Bernardo Pérez-González Yessica Ávila-Palacios Lineth Sigala-Pedroza Eira Huerta-Ávila María Angelina Vargas-Álvarez Carlos Sánchez-Jaimes Mariana Cárdenas-Vera Roopa Mehta Manuel Alejandro López-Flores A La Torre Iliana Manjarrez-Martínez Griselda Xochitl Brito-Córdova Julia M. Zuarth-Vázquez Arturo Vega-Beyhart Guadalupe López-Carrasco Richard J. Johnson Francisco Javier Gómez-Pérez |
| author_sort | Miguel Ángel Gómez-Sámano |
| collection | DOAJ |
| description | The aim of this single center cross-sectional study was to investigate the association between fructose intake and albuminuria in subjects with type 2 diabetes mellitus (T2DM). This is a single center cross-sectional study. One hundred and forty-three subjects with T2DM were recruited from the Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran. The median daily fructose intake was estimated with a prospective food registry during 3 days (2 week-days and one weekend day) and they were divided into low fructose intake (<25 g/day) and high fructose intake (≥ 25 g/day). Complete clinical and biochemical evaluations were performed, including anthropometric variables and a 24-hour urine collection for albuminuria determination. One hundred and thirty-six subjects were analyzed in this study. We found a positive significant association between daily fructose intake and albuminuria (ρ= 0.178, p=0.038) in subjects with type 2 diabetes mellitus. Other variables significantly associated with albuminuria were body mass index (BMI) (ρ= 0.170, p=0.048), mean arterial pressure (MAP) (ρ= 0.280, p=0.001), glycated hemoglobin (A1c) (ρ= 0.197, p=0.022), and triglycerides (ρ= 0.219, p=0.010). After adjustment for confounding variables we found a significant and independent association between fructose intake and albuminuria (β= 13.96, p=0.006). We found a statistically significant higher albuminuria (60.8 [12.8-228.5] versus 232.2 [27.2-1273.0] mg/day, p 0.002), glycated hemoglobin (8.6±1.61 versus 9.6±2.1 %), p= 0.003, and uric acid (6.27±1.8 versus 7.2±1.5 mg/dL), p=0.012, in the group of high fructose intake versus the group with low fructose intake, and a statistically significant lower creatinine clearance (76.5±30.98 mL/min versus 94.9±36.8, p=0.014) in the group with high fructose intake versus the group with low fructose intake. In summary we found that a higher fructose intake is associated with greater albuminuria in subjects with T2DM. |
| format | Article |
| id | doaj-art-47e623b134874686abd7cf8a8667bdff |
| institution | Kabale University |
| issn | 2090-214X 2090-2158 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj-art-47e623b134874686abd7cf8a8667bdff2025-08-20T03:36:07ZengWileyInternational Journal of Nephrology2090-214X2090-21582018-01-01201810.1155/2018/54594395459439A Higher Fructose Intake Is Associated with Greater Albuminuria in Subjects with Type 2 Diabetes MellitusMiguel Ángel Gómez-Sámano0Paloma Almeda-Valdes1Daniel Cuevas-Ramos2María Fernanda Navarro-Flores3Héctor Donaldo Espinosa-Salazar4Mayela Martínez-Saavedra5Jefsi Argelia León-Domínguez6Víctor Manuel Enríquez-Estrada7Ana Laura López-González8Ana Laura Sarmiento-Moreno9Lucero Alejandra Rivera-González10Óscar Alfredo Juárez-León11Bernardo Pérez-González12Yessica Ávila-Palacios13Lineth Sigala-Pedroza14Eira Huerta-Ávila15María Angelina Vargas-Álvarez16Carlos Sánchez-Jaimes17Mariana Cárdenas-Vera18Roopa Mehta19Manuel Alejandro López-Flores A La Torre20Iliana Manjarrez-Martínez21Griselda Xochitl Brito-Córdova22Julia M. Zuarth-Vázquez23Arturo Vega-Beyhart24Guadalupe López-Carrasco25Richard J. Johnson26Francisco Javier Gómez-Pérez27Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, 14080 Mexico City, MexicoDepartment of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, 14080 Mexico City, MexicoDepartment of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, 14080 Mexico City, MexicoDepartment of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, 14080 Mexico City, MexicoDepartment of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, 14080 Mexico City, MexicoDepartment of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, 14080 Mexico City, MexicoDepartment of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, 14080 Mexico City, MexicoDepartment of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, 14080 Mexico City, MexicoDepartment of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, 14080 Mexico City, MexicoDepartment of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, 14080 Mexico City, MexicoDepartment of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, 14080 Mexico City, MexicoDepartment of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, 14080 Mexico City, MexicoDepartment of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, 14080 Mexico City, MexicoDepartment of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, 14080 Mexico City, MexicoDepartment of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, 14080 Mexico City, MexicoDepartment of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, 14080 Mexico City, MexicoDepartment of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, 14080 Mexico City, MexicoDepartment of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, 14080 Mexico City, MexicoDepartment of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, 14080 Mexico City, MexicoDepartment of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, 14080 Mexico City, MexicoDepartment of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, 14080 Mexico City, MexicoDepartment of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, 14080 Mexico City, MexicoDepartment of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, 14080 Mexico City, MexicoDepartment of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, 14080 Mexico City, MexicoDepartment of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, 14080 Mexico City, MexicoDepartment of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, 14080 Mexico City, MexicoDivision of Renal Diseases and Hypertension, University of Colorado, Denver 12631, Aurora, USADepartment of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, 14080 Mexico City, MexicoThe aim of this single center cross-sectional study was to investigate the association between fructose intake and albuminuria in subjects with type 2 diabetes mellitus (T2DM). This is a single center cross-sectional study. One hundred and forty-three subjects with T2DM were recruited from the Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran. The median daily fructose intake was estimated with a prospective food registry during 3 days (2 week-days and one weekend day) and they were divided into low fructose intake (<25 g/day) and high fructose intake (≥ 25 g/day). Complete clinical and biochemical evaluations were performed, including anthropometric variables and a 24-hour urine collection for albuminuria determination. One hundred and thirty-six subjects were analyzed in this study. We found a positive significant association between daily fructose intake and albuminuria (ρ= 0.178, p=0.038) in subjects with type 2 diabetes mellitus. Other variables significantly associated with albuminuria were body mass index (BMI) (ρ= 0.170, p=0.048), mean arterial pressure (MAP) (ρ= 0.280, p=0.001), glycated hemoglobin (A1c) (ρ= 0.197, p=0.022), and triglycerides (ρ= 0.219, p=0.010). After adjustment for confounding variables we found a significant and independent association between fructose intake and albuminuria (β= 13.96, p=0.006). We found a statistically significant higher albuminuria (60.8 [12.8-228.5] versus 232.2 [27.2-1273.0] mg/day, p 0.002), glycated hemoglobin (8.6±1.61 versus 9.6±2.1 %), p= 0.003, and uric acid (6.27±1.8 versus 7.2±1.5 mg/dL), p=0.012, in the group of high fructose intake versus the group with low fructose intake, and a statistically significant lower creatinine clearance (76.5±30.98 mL/min versus 94.9±36.8, p=0.014) in the group with high fructose intake versus the group with low fructose intake. In summary we found that a higher fructose intake is associated with greater albuminuria in subjects with T2DM.http://dx.doi.org/10.1155/2018/5459439 |
| spellingShingle | Miguel Ángel Gómez-Sámano Paloma Almeda-Valdes Daniel Cuevas-Ramos María Fernanda Navarro-Flores Héctor Donaldo Espinosa-Salazar Mayela Martínez-Saavedra Jefsi Argelia León-Domínguez Víctor Manuel Enríquez-Estrada Ana Laura López-González Ana Laura Sarmiento-Moreno Lucero Alejandra Rivera-González Óscar Alfredo Juárez-León Bernardo Pérez-González Yessica Ávila-Palacios Lineth Sigala-Pedroza Eira Huerta-Ávila María Angelina Vargas-Álvarez Carlos Sánchez-Jaimes Mariana Cárdenas-Vera Roopa Mehta Manuel Alejandro López-Flores A La Torre Iliana Manjarrez-Martínez Griselda Xochitl Brito-Córdova Julia M. Zuarth-Vázquez Arturo Vega-Beyhart Guadalupe López-Carrasco Richard J. Johnson Francisco Javier Gómez-Pérez A Higher Fructose Intake Is Associated with Greater Albuminuria in Subjects with Type 2 Diabetes Mellitus International Journal of Nephrology |
| title | A Higher Fructose Intake Is Associated with Greater Albuminuria in Subjects with Type 2 Diabetes Mellitus |
| title_full | A Higher Fructose Intake Is Associated with Greater Albuminuria in Subjects with Type 2 Diabetes Mellitus |
| title_fullStr | A Higher Fructose Intake Is Associated with Greater Albuminuria in Subjects with Type 2 Diabetes Mellitus |
| title_full_unstemmed | A Higher Fructose Intake Is Associated with Greater Albuminuria in Subjects with Type 2 Diabetes Mellitus |
| title_short | A Higher Fructose Intake Is Associated with Greater Albuminuria in Subjects with Type 2 Diabetes Mellitus |
| title_sort | higher fructose intake is associated with greater albuminuria in subjects with type 2 diabetes mellitus |
| url | http://dx.doi.org/10.1155/2018/5459439 |
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