SAFETY PROFILE OF DIPEPTIDYL PEPTIDASE-4 INHIBITORS
Dipeptidyl peptidase-4 inhibitors (DPP-4 inhibitors) are oral antidiabetic agents commonly used for the treatment of type 2 diabetes mellitus. More than ten years of clinical experience with this group of drugs provides evidence of their efficacy and good tolerability especially in patients at ris...
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| Language: | English |
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Trakia University
2023-03-01
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| Series: | Trakia Journal of Sciences |
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| Online Access: | http://tru.uni-sz.bg/tsj/Volume%2021,%202023,%20Number%201,%20Series%20Biomedical%20Sciences/9_M.Ganeva.pdf |
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| author | M. Ganeva |
| author_facet | M. Ganeva |
| author_sort | M. Ganeva |
| collection | DOAJ |
| description | Dipeptidyl peptidase-4 inhibitors (DPP-4 inhibitors) are oral antidiabetic agents commonly used for the
treatment of type 2 diabetes mellitus. More than ten years of clinical experience with this group of drugs
provides evidence of their efficacy and good tolerability especially in patients at risk of hypoglycemia. DPP4 inhibitors act by increasing the levels of the incretins glucagon-like peptide-1 (GLP-1) and glucosedependent insulinotropic peptide (GIP) and thus augmenting glucose-induced insulin secretion. The enzyme
DPP-4 degrades plenty of substrates including chemokines, cytokines, and neuropeptides. Thus the inhibition
of DPP-4 may affect many biological and pathological processes. Although rarely DPP-4 inhibitors have
been reported to induce the development of infections, heart failure, liver injury and pancreatitis. The longterm effects of DPP-4 inhibition on the immune function are still not clarified. The close monitoring of
polymorbid patients using DPP-4 inhibitors, and the reporting of possible adverse reactions associated with
these drugs is warranted. |
| format | Article |
| id | doaj-art-47e52630a4de40409d2adc1c3b2a07d1 |
| institution | DOAJ |
| issn | 1313-3551 |
| language | English |
| publishDate | 2023-03-01 |
| publisher | Trakia University |
| record_format | Article |
| series | Trakia Journal of Sciences |
| spelling | doaj-art-47e52630a4de40409d2adc1c3b2a07d12025-08-20T02:54:53ZengTrakia UniversityTrakia Journal of Sciences1313-35512023-03-01211546210.15547/tjs.2023.01.009SAFETY PROFILE OF DIPEPTIDYL PEPTIDASE-4 INHIBITORSM. GanevaDipeptidyl peptidase-4 inhibitors (DPP-4 inhibitors) are oral antidiabetic agents commonly used for the treatment of type 2 diabetes mellitus. More than ten years of clinical experience with this group of drugs provides evidence of their efficacy and good tolerability especially in patients at risk of hypoglycemia. DPP4 inhibitors act by increasing the levels of the incretins glucagon-like peptide-1 (GLP-1) and glucosedependent insulinotropic peptide (GIP) and thus augmenting glucose-induced insulin secretion. The enzyme DPP-4 degrades plenty of substrates including chemokines, cytokines, and neuropeptides. Thus the inhibition of DPP-4 may affect many biological and pathological processes. Although rarely DPP-4 inhibitors have been reported to induce the development of infections, heart failure, liver injury and pancreatitis. The longterm effects of DPP-4 inhibition on the immune function are still not clarified. The close monitoring of polymorbid patients using DPP-4 inhibitors, and the reporting of possible adverse reactions associated with these drugs is warranted.http://tru.uni-sz.bg/tsj/Volume%2021,%202023,%20Number%201,%20Series%20Biomedical%20Sciences/9_M.Ganeva.pdf: dipeptidyl peptidase-4 inhibitorsdiabetes mellitusadverse reaction |
| spellingShingle | M. Ganeva SAFETY PROFILE OF DIPEPTIDYL PEPTIDASE-4 INHIBITORS Trakia Journal of Sciences : dipeptidyl peptidase-4 inhibitors diabetes mellitus adverse reaction |
| title | SAFETY PROFILE OF DIPEPTIDYL PEPTIDASE-4 INHIBITORS |
| title_full | SAFETY PROFILE OF DIPEPTIDYL PEPTIDASE-4 INHIBITORS |
| title_fullStr | SAFETY PROFILE OF DIPEPTIDYL PEPTIDASE-4 INHIBITORS |
| title_full_unstemmed | SAFETY PROFILE OF DIPEPTIDYL PEPTIDASE-4 INHIBITORS |
| title_short | SAFETY PROFILE OF DIPEPTIDYL PEPTIDASE-4 INHIBITORS |
| title_sort | safety profile of dipeptidyl peptidase 4 inhibitors |
| topic | : dipeptidyl peptidase-4 inhibitors diabetes mellitus adverse reaction |
| url | http://tru.uni-sz.bg/tsj/Volume%2021,%202023,%20Number%201,%20Series%20Biomedical%20Sciences/9_M.Ganeva.pdf |
| work_keys_str_mv | AT mganeva safetyprofileofdipeptidylpeptidase4inhibitors |