Update on the Use of Inhaled Nitric Oxide

A literature review on nitric oxide would identify thousands of citations on the biological implications of this molecule. From the perspective of respiratory care, the effect inhaled nitric oxide has on pulmonary vasculature is the most intriguing. Over the past five years inhaled nitric oxide has...

Full description

Saved in:
Bibliographic Details
Main Author: Robert M Kacmarek
Format: Article
Language:English
Published: Wiley 1996-01-01
Series:Canadian Respiratory Journal
Online Access:http://dx.doi.org/10.1155/1996/831514
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1832556331140120576
author Robert M Kacmarek
author_facet Robert M Kacmarek
author_sort Robert M Kacmarek
collection DOAJ
description A literature review on nitric oxide would identify thousands of citations on the biological implications of this molecule. From the perspective of respiratory care, the effect inhaled nitric oxide has on pulmonary vasculature is the most intriguing. Over the past five years inhaled nitric oxide has been shown to be useful in the management of oxygenation during acute respiratory distress syndrome, alternation of pulmonary vascular tone in persistent pulmonary hypertension in the newborn, and in the management of chronic pulmonary hypertension in both heart and lung transplant candidates, as well as other potential clinical uses. The key physioligical response is vasodilation of pulmonary vessels in communication with well ventilated lung units and the absence of systemic vascular effects by rapid binding to hemoglobin. Nitric oxide therapy is considered experimental. A delivery system is not commercially available. This has resulted in the development of makeshift delivery systems, many of which may have the potential for adverse effects.
format Article
id doaj-art-47e2c0ffa64f47c6b59ffebbddd13c43
institution Kabale University
issn 1198-2241
language English
publishDate 1996-01-01
publisher Wiley
record_format Article
series Canadian Respiratory Journal
spelling doaj-art-47e2c0ffa64f47c6b59ffebbddd13c432025-02-03T05:45:46ZengWileyCanadian Respiratory Journal1198-22411996-01-013637337610.1155/1996/831514Update on the Use of Inhaled Nitric OxideRobert M KacmarekA literature review on nitric oxide would identify thousands of citations on the biological implications of this molecule. From the perspective of respiratory care, the effect inhaled nitric oxide has on pulmonary vasculature is the most intriguing. Over the past five years inhaled nitric oxide has been shown to be useful in the management of oxygenation during acute respiratory distress syndrome, alternation of pulmonary vascular tone in persistent pulmonary hypertension in the newborn, and in the management of chronic pulmonary hypertension in both heart and lung transplant candidates, as well as other potential clinical uses. The key physioligical response is vasodilation of pulmonary vessels in communication with well ventilated lung units and the absence of systemic vascular effects by rapid binding to hemoglobin. Nitric oxide therapy is considered experimental. A delivery system is not commercially available. This has resulted in the development of makeshift delivery systems, many of which may have the potential for adverse effects.http://dx.doi.org/10.1155/1996/831514
spellingShingle Robert M Kacmarek
Update on the Use of Inhaled Nitric Oxide
Canadian Respiratory Journal
title Update on the Use of Inhaled Nitric Oxide
title_full Update on the Use of Inhaled Nitric Oxide
title_fullStr Update on the Use of Inhaled Nitric Oxide
title_full_unstemmed Update on the Use of Inhaled Nitric Oxide
title_short Update on the Use of Inhaled Nitric Oxide
title_sort update on the use of inhaled nitric oxide
url http://dx.doi.org/10.1155/1996/831514
work_keys_str_mv AT robertmkacmarek updateontheuseofinhalednitricoxide