Design, Synthesis, enzyme inhibitory activity and molecular docking studies of new 1,2,3-triazole linked nucleobases

Design, Synthesis, enzyme inhibitory activity and molecular docking studies of new 1,2,3-triazole linked nucleobases

Thirteen novel 1,2,3-triazole linked nucleobases (5a-m) were designed and efficiently synthesized as potential human enzyme inhibitors. The target compounds were synthesized by using Copper (I)-catalysed Huisgen-Sharpless-Meldal 1,3-dipolar cycloaddition reaction of propargylated nucleobases and sub...

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Bibliographic Details
Main Authors: Aditya Aggarwal, Chanchal Vashisth, Komal Bharti, Neera Raghav, Surender Kumar
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Results in Chemistry
Subjects:
1
2
3-Triazole
3-Dipolar cycloaddition
Nucleobases
Enzyme inhibitor
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715624007070
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