Lipid Accumulation Product Is More Related to Insulin Resistance than the Visceral Adiposity Index in the Maracaibo City Population, Venezuela
Background. Visceral adiposity is related to insulin resistance (IR), a metabolic state considered as a risk factor for other cardiometabolic diseases. In that matter, mathematical indexes such as the visceral adiposity index (VAI) and the lipid accumulation product (LAP) could indirectly assess IR...
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Wiley
2021-01-01
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| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2021/5514901 |
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| author | Valmore Bermúdez Juan Salazar Jorge Fuenmayor Manuel Nava Ángel Ortega Pablo Duran Milagros Rojas Roberto Añez Alejandra Rivas-Montenegro Lissé Angarita Maricarmen Chacín Clímaco Cano Manuel Velasco Joselyn Rojas |
| author_facet | Valmore Bermúdez Juan Salazar Jorge Fuenmayor Manuel Nava Ángel Ortega Pablo Duran Milagros Rojas Roberto Añez Alejandra Rivas-Montenegro Lissé Angarita Maricarmen Chacín Clímaco Cano Manuel Velasco Joselyn Rojas |
| author_sort | Valmore Bermúdez |
| collection | DOAJ |
| description | Background. Visceral adiposity is related to insulin resistance (IR), a metabolic state considered as a risk factor for other cardiometabolic diseases. In that matter, mathematical indexes such as the visceral adiposity index (VAI) and the lipid accumulation product (LAP) could indirectly assess IR based on visceral adiposity. Objective. To evaluate the association and diagnostic accuracy of VAI and LAP to diagnose IR in the adult population of Maracaibo city. Methods. This is a cross-sectional descriptive study with multistage sampling. Receiver operating characteristic (ROC) curves were built to determine VAI and LAP cutoff points to predict IR. A set of logistic regression models was constructed according to sociodemographic, psychobiologic, and metabolic variables. Results. 1818 subjects were evaluated (51.4% women). The area under the curve (AUC) values for LAP and VAI were 0.689 (0.665–0.714) and 0.645 (0.619–0.670), respectively. Both indexes showed a higher IR risk in the upper tertile in bivariate analysis. However, in the logistic regression analysis for the IR risk, only the 2nd (OR: 1.91; 95% CI: 1.37–2.65; p<0.01) and 3rd (OR: 5.40; 95% CI: 3.48–8.39; p<0.01) LAP tertiles showed a significant increase. This behaviour was also observed after adjusting for hs-C-reactive protein (hs-CPR). Conclusion. Although both indexes show a low predictive capacity in individuals with IR in the Maracaibo city population, the LAP index was more strongly associated with IR. |
| format | Article |
| id | doaj-art-47dcc8884cc54adc94a384bcd38119ea |
| institution | OA Journals |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-47dcc8884cc54adc94a384bcd38119ea2025-08-20T02:37:54ZengWileyJournal of Obesity2090-07082090-07162021-01-01202110.1155/2021/55149015514901Lipid Accumulation Product Is More Related to Insulin Resistance than the Visceral Adiposity Index in the Maracaibo City Population, VenezuelaValmore Bermúdez0Juan Salazar1Jorge Fuenmayor2Manuel Nava3Ángel Ortega4Pablo Duran5Milagros Rojas6Roberto Añez7Alejandra Rivas-Montenegro8Lissé Angarita9Maricarmen Chacín10Clímaco Cano11Manuel Velasco12Joselyn Rojas13Universidad Simón Bolívar, Facultad de Ciencias de La Salud, Barranquilla, ColombiaEndocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo, VenezuelaEndocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo, VenezuelaEndocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo, VenezuelaEndocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo, VenezuelaEndocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo, VenezuelaEndocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo, VenezuelaDepartment of Endocrine and Nutrition, Gregorio Marañón General University Hospital, Madrid, SpainDepartment of Endocrine and Nutrition, Gregorio Marañón General University Hospital, Madrid, SpainUniversidad Andres Bello, Carrera de Nutrición, Concepción, ChileUniversidad Simón Bolívar, Facultad de Ciencias de La Salud, Barranquilla, ColombiaEndocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo, VenezuelaUniversidad Central de Venezuela, Escuela de Medicina José María Vargas, Caracas, VenezuelaDivision of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USABackground. Visceral adiposity is related to insulin resistance (IR), a metabolic state considered as a risk factor for other cardiometabolic diseases. In that matter, mathematical indexes such as the visceral adiposity index (VAI) and the lipid accumulation product (LAP) could indirectly assess IR based on visceral adiposity. Objective. To evaluate the association and diagnostic accuracy of VAI and LAP to diagnose IR in the adult population of Maracaibo city. Methods. This is a cross-sectional descriptive study with multistage sampling. Receiver operating characteristic (ROC) curves were built to determine VAI and LAP cutoff points to predict IR. A set of logistic regression models was constructed according to sociodemographic, psychobiologic, and metabolic variables. Results. 1818 subjects were evaluated (51.4% women). The area under the curve (AUC) values for LAP and VAI were 0.689 (0.665–0.714) and 0.645 (0.619–0.670), respectively. Both indexes showed a higher IR risk in the upper tertile in bivariate analysis. However, in the logistic regression analysis for the IR risk, only the 2nd (OR: 1.91; 95% CI: 1.37–2.65; p<0.01) and 3rd (OR: 5.40; 95% CI: 3.48–8.39; p<0.01) LAP tertiles showed a significant increase. This behaviour was also observed after adjusting for hs-C-reactive protein (hs-CPR). Conclusion. Although both indexes show a low predictive capacity in individuals with IR in the Maracaibo city population, the LAP index was more strongly associated with IR.http://dx.doi.org/10.1155/2021/5514901 |
| spellingShingle | Valmore Bermúdez Juan Salazar Jorge Fuenmayor Manuel Nava Ángel Ortega Pablo Duran Milagros Rojas Roberto Añez Alejandra Rivas-Montenegro Lissé Angarita Maricarmen Chacín Clímaco Cano Manuel Velasco Joselyn Rojas Lipid Accumulation Product Is More Related to Insulin Resistance than the Visceral Adiposity Index in the Maracaibo City Population, Venezuela Journal of Obesity |
| title | Lipid Accumulation Product Is More Related to Insulin Resistance than the Visceral Adiposity Index in the Maracaibo City Population, Venezuela |
| title_full | Lipid Accumulation Product Is More Related to Insulin Resistance than the Visceral Adiposity Index in the Maracaibo City Population, Venezuela |
| title_fullStr | Lipid Accumulation Product Is More Related to Insulin Resistance than the Visceral Adiposity Index in the Maracaibo City Population, Venezuela |
| title_full_unstemmed | Lipid Accumulation Product Is More Related to Insulin Resistance than the Visceral Adiposity Index in the Maracaibo City Population, Venezuela |
| title_short | Lipid Accumulation Product Is More Related to Insulin Resistance than the Visceral Adiposity Index in the Maracaibo City Population, Venezuela |
| title_sort | lipid accumulation product is more related to insulin resistance than the visceral adiposity index in the maracaibo city population venezuela |
| url | http://dx.doi.org/10.1155/2021/5514901 |
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