Optimizing Bone Regeneration with Demineralized Dentin-Derived Graft Material: Impact of Demineralization Duration in a Rabbit Calvaria Model
This study evaluated the regenerative potential of demineralized dentin-derived matrix (DDM) as a bone graft material in rabbit calvaria. DDM, sourced from extracted teeth, is emerging as an alternative to traditional grafts like allografts and xenografts. We aimed to identify the most effective dem...
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MDPI AG
2024-11-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/15/11/331 |
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| author | Bounghoon Lee Hyunsuk Choi Dong-Seok Sohn |
| author_facet | Bounghoon Lee Hyunsuk Choi Dong-Seok Sohn |
| author_sort | Bounghoon Lee |
| collection | DOAJ |
| description | This study evaluated the regenerative potential of demineralized dentin-derived matrix (DDM) as a bone graft material in rabbit calvaria. DDM, sourced from extracted teeth, is emerging as an alternative to traditional grafts like allografts and xenografts. We aimed to identify the most effective demineralization protocol to optimize the regenerative capacity of DDM. Four groups were compared: a control group without grafts, a non-demineralized DDM group, and two demineralized DDM groups (15 and 30 min demineralization). Histomorphometric analysis was conducted in a randomized and blinded setting at 2, 4, and 8 weeks post-graft placement. The results revealed that the 15 min demineralized DDM group showed the most significant new bone formation (42.51% ± 6.40% at 8 weeks; <i>p</i> < 0.05), suggesting its potential as a highly effective regenerative graft material. |
| format | Article |
| id | doaj-art-47dbcd752e284d5d94a505ea8adb3dc3 |
| institution | OA Journals |
| issn | 2079-4983 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj-art-47dbcd752e284d5d94a505ea8adb3dc32025-08-20T02:04:58ZengMDPI AGJournal of Functional Biomaterials2079-49832024-11-01151133110.3390/jfb15110331Optimizing Bone Regeneration with Demineralized Dentin-Derived Graft Material: Impact of Demineralization Duration in a Rabbit Calvaria ModelBounghoon Lee0Hyunsuk Choi1Dong-Seok Sohn2Department of Dentistry and Oral and Maxillofacial Surgery, Daegu Catholic University Medical Center, Daegu 42472, Republic of KoreaDepartment of Dentistry and Prosthodontics, Daegu Catholic University School of Medicine, Daegu 42472, Republic of KoreaDepartment of Dentistry and Oral and Maxillofacial Surgery, Daegu Catholic University Medical Center, Daegu 42472, Republic of KoreaThis study evaluated the regenerative potential of demineralized dentin-derived matrix (DDM) as a bone graft material in rabbit calvaria. DDM, sourced from extracted teeth, is emerging as an alternative to traditional grafts like allografts and xenografts. We aimed to identify the most effective demineralization protocol to optimize the regenerative capacity of DDM. Four groups were compared: a control group without grafts, a non-demineralized DDM group, and two demineralized DDM groups (15 and 30 min demineralization). Histomorphometric analysis was conducted in a randomized and blinded setting at 2, 4, and 8 weeks post-graft placement. The results revealed that the 15 min demineralized DDM group showed the most significant new bone formation (42.51% ± 6.40% at 8 weeks; <i>p</i> < 0.05), suggesting its potential as a highly effective regenerative graft material.https://www.mdpi.com/2079-4983/15/11/331bone graftbone regenerationrabbit calvariahistologydentin-derived matrix |
| spellingShingle | Bounghoon Lee Hyunsuk Choi Dong-Seok Sohn Optimizing Bone Regeneration with Demineralized Dentin-Derived Graft Material: Impact of Demineralization Duration in a Rabbit Calvaria Model Journal of Functional Biomaterials bone graft bone regeneration rabbit calvaria histology dentin-derived matrix |
| title | Optimizing Bone Regeneration with Demineralized Dentin-Derived Graft Material: Impact of Demineralization Duration in a Rabbit Calvaria Model |
| title_full | Optimizing Bone Regeneration with Demineralized Dentin-Derived Graft Material: Impact of Demineralization Duration in a Rabbit Calvaria Model |
| title_fullStr | Optimizing Bone Regeneration with Demineralized Dentin-Derived Graft Material: Impact of Demineralization Duration in a Rabbit Calvaria Model |
| title_full_unstemmed | Optimizing Bone Regeneration with Demineralized Dentin-Derived Graft Material: Impact of Demineralization Duration in a Rabbit Calvaria Model |
| title_short | Optimizing Bone Regeneration with Demineralized Dentin-Derived Graft Material: Impact of Demineralization Duration in a Rabbit Calvaria Model |
| title_sort | optimizing bone regeneration with demineralized dentin derived graft material impact of demineralization duration in a rabbit calvaria model |
| topic | bone graft bone regeneration rabbit calvaria histology dentin-derived matrix |
| url | https://www.mdpi.com/2079-4983/15/11/331 |
| work_keys_str_mv | AT bounghoonlee optimizingboneregenerationwithdemineralizeddentinderivedgraftmaterialimpactofdemineralizationdurationinarabbitcalvariamodel AT hyunsukchoi optimizingboneregenerationwithdemineralizeddentinderivedgraftmaterialimpactofdemineralizationdurationinarabbitcalvariamodel AT dongseoksohn optimizingboneregenerationwithdemineralizeddentinderivedgraftmaterialimpactofdemineralizationdurationinarabbitcalvariamodel |