Diagnosis of Superficial Gastric Lesions Together with Six Gastric Lymphoma Cases via Probe-Based Confocal Laser Endomicroscopy: A Retrospective Observational Study
Objective. To evaluate the performance of probe-based confocal laser endomicroscopy (pCLE) in diagnosis of gastric lesions. Methods. An outpatient department- (OPD-) based retrospective study was conducted for patients with suspected upper gastrointestinal (GI) tract lesions who underwent pCLE betwe...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2018/5073182 |
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| author | Qian Chen Heng-Hui Cheng Shuang Deng Dong Kuang Chang Shu Li Cao Guang-Quan Liao Qiao-Zhen Guo Qi Zhou |
| author_facet | Qian Chen Heng-Hui Cheng Shuang Deng Dong Kuang Chang Shu Li Cao Guang-Quan Liao Qiao-Zhen Guo Qi Zhou |
| author_sort | Qian Chen |
| collection | DOAJ |
| description | Objective. To evaluate the performance of probe-based confocal laser endomicroscopy (pCLE) in diagnosis of gastric lesions. Methods. An outpatient department- (OPD-) based retrospective study was conducted for patients with suspected upper gastrointestinal (GI) tract lesions who underwent pCLE between 2014 and 2016 at a tertiary hospital in China. Final diagnosis was based on the histopathological reports. CLE reports were compared to histopathological reports to evaluate the diagnostic ability, including sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and diagnostic accuracy. Results. 322 of 380 patients were diagnosed with gastric lesions via pCLE, including inflammation and benign ulcers (n=110), atrophy and intestinal metaplasia (n=152), intraepithelial neoplasia (n=27), adenocarcinoma (n=27), and lymphoma (n=6). In total, the diagnostic ability of CLE in evaluation of gastric lesions showed sensitivity 72.4% (95% confidence interval (CI): 67.1–77.2%); specificity 93.1% (95% CI: 5.6–8.4%); PPV 72.4% (95% CI: 67.1–77.2%); NPV 93.1% (95% CI: 5.6–8.4%); and accuracy 88.9% (95% CI: 87.3–90.4%), respectively. We further observed the capability of pCLE in diagnosing six gastric lymphoma showing those affected mucosa densely infiltrated with identical and round-shaped abnormal cells. Immunohistochemistry analysis confirmed one patient with diffuse large B-cell non-Hodgkin’s lymphoma (DLBCL) and five with mucosa-associated lymphoid tissue (MALT) lymphoma. Conclusion. pCLE is an accurate tool for the detection of gastric lesions and shows optimal values of sensitivity and negative predictivity. Moreover, combining pCLE with white light endoscopy (WLE) may be a promising adjunct to conventional biopsy sampling in evaluating GI tract with suspected lymphoma. |
| format | Article |
| id | doaj-art-47d9693449404990b5bb131a73cb048b |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-47d9693449404990b5bb131a73cb048b2025-02-03T06:07:52ZengWileyGastroenterology Research and Practice1687-61211687-630X2018-01-01201810.1155/2018/50731825073182Diagnosis of Superficial Gastric Lesions Together with Six Gastric Lymphoma Cases via Probe-Based Confocal Laser Endomicroscopy: A Retrospective Observational StudyQian Chen0Heng-Hui Cheng1Shuang Deng2Dong Kuang3Chang Shu4Li Cao5Guang-Quan Liao6Qiao-Zhen Guo7Qi Zhou8Endoscopic Unit, Department of Gastroenterology and Hepatology at Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan, ChinaDepartment of Pathology at Tongji Hospital, Tongji Medical College, HUST, Wuhan, ChinaTongji Medical College, HUST, Wuhan, ChinaDepartment of Pathology at Tongji Hospital, Tongji Medical College, HUST, Wuhan, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, HUST, Wuhan, ChinaEndoscopic Unit, Department of Gastroenterology and Hepatology at Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan, ChinaEndoscopic Unit, Department of Gastroenterology and Hepatology at Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan, ChinaEndoscopic Unit, Department of Gastroenterology and Hepatology at Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan, ChinaEndoscopic Unit, Department of Gastroenterology and Hepatology at Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan, ChinaObjective. To evaluate the performance of probe-based confocal laser endomicroscopy (pCLE) in diagnosis of gastric lesions. Methods. An outpatient department- (OPD-) based retrospective study was conducted for patients with suspected upper gastrointestinal (GI) tract lesions who underwent pCLE between 2014 and 2016 at a tertiary hospital in China. Final diagnosis was based on the histopathological reports. CLE reports were compared to histopathological reports to evaluate the diagnostic ability, including sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and diagnostic accuracy. Results. 322 of 380 patients were diagnosed with gastric lesions via pCLE, including inflammation and benign ulcers (n=110), atrophy and intestinal metaplasia (n=152), intraepithelial neoplasia (n=27), adenocarcinoma (n=27), and lymphoma (n=6). In total, the diagnostic ability of CLE in evaluation of gastric lesions showed sensitivity 72.4% (95% confidence interval (CI): 67.1–77.2%); specificity 93.1% (95% CI: 5.6–8.4%); PPV 72.4% (95% CI: 67.1–77.2%); NPV 93.1% (95% CI: 5.6–8.4%); and accuracy 88.9% (95% CI: 87.3–90.4%), respectively. We further observed the capability of pCLE in diagnosing six gastric lymphoma showing those affected mucosa densely infiltrated with identical and round-shaped abnormal cells. Immunohistochemistry analysis confirmed one patient with diffuse large B-cell non-Hodgkin’s lymphoma (DLBCL) and five with mucosa-associated lymphoid tissue (MALT) lymphoma. Conclusion. pCLE is an accurate tool for the detection of gastric lesions and shows optimal values of sensitivity and negative predictivity. Moreover, combining pCLE with white light endoscopy (WLE) may be a promising adjunct to conventional biopsy sampling in evaluating GI tract with suspected lymphoma.http://dx.doi.org/10.1155/2018/5073182 |
| spellingShingle | Qian Chen Heng-Hui Cheng Shuang Deng Dong Kuang Chang Shu Li Cao Guang-Quan Liao Qiao-Zhen Guo Qi Zhou Diagnosis of Superficial Gastric Lesions Together with Six Gastric Lymphoma Cases via Probe-Based Confocal Laser Endomicroscopy: A Retrospective Observational Study Gastroenterology Research and Practice |
| title | Diagnosis of Superficial Gastric Lesions Together with Six Gastric Lymphoma Cases via Probe-Based Confocal Laser Endomicroscopy: A Retrospective Observational Study |
| title_full | Diagnosis of Superficial Gastric Lesions Together with Six Gastric Lymphoma Cases via Probe-Based Confocal Laser Endomicroscopy: A Retrospective Observational Study |
| title_fullStr | Diagnosis of Superficial Gastric Lesions Together with Six Gastric Lymphoma Cases via Probe-Based Confocal Laser Endomicroscopy: A Retrospective Observational Study |
| title_full_unstemmed | Diagnosis of Superficial Gastric Lesions Together with Six Gastric Lymphoma Cases via Probe-Based Confocal Laser Endomicroscopy: A Retrospective Observational Study |
| title_short | Diagnosis of Superficial Gastric Lesions Together with Six Gastric Lymphoma Cases via Probe-Based Confocal Laser Endomicroscopy: A Retrospective Observational Study |
| title_sort | diagnosis of superficial gastric lesions together with six gastric lymphoma cases via probe based confocal laser endomicroscopy a retrospective observational study |
| url | http://dx.doi.org/10.1155/2018/5073182 |
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