Vasculitis After a Vaccine: Rare Adverse Reaction Following a COVID-19 Vaccine
Fatigue, fever, localized soreness, urticaria, and rash are common adverse reactions of COVID-19 vaccines. However, the occurrence of serious autoimmune reactions is quite rare. Cutaneous small-vessel vasculitis is an autoimmune disorder that manifests with palpable purpura and petechiae involving e...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
American College of Physicians
2023-10-01
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| Series: | Annals of Internal Medicine: Clinical Cases |
| Online Access: | https://www.acpjournals.org/doi/10.7326/aimcc.2022.1043 |
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| Summary: | Fatigue, fever, localized soreness, urticaria, and rash are common adverse reactions of COVID-19 vaccines. However, the occurrence of serious autoimmune reactions is quite rare. Cutaneous small-vessel vasculitis is an autoimmune disorder that manifests with palpable purpura and petechiae involving extremities. It results from neutrophilic inflammation within and around dermal vessels and is usually self-limited. We report a 55-year-old woman presenting with a rash 48 hours after receiving the third (Moderna) COVID-19 vaccine dose. Blood investigations and a skin punch biopsy confirmed the diagnosis of COVID-19 vaccine–induced cutaneous small-vessel vasculitis. The patient ultimately improved after inpatient treatment with systemic steroids. |
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| ISSN: | 2767-7664 |