Piperine: Chemical, biological and nanotechnological applications

Piperine (PIP) is an alkaloid present in several species of piper, mainly Piper nigrum Linn. and P. longum, among other species. The present article provides a comprehensive review of PIP research in the last years concerning its chemical properties, synthesis, absorption, metabolism, bioavailabilit...

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Main Authors: Quijia Christian Rafael, Araujo Victor Hugo, Chorilli Marlus
Format: Article
Language:English
Published: Sciendo 2021-06-01
Series:Acta Pharmaceutica
Subjects:
Online Access:https://doi.org/10.2478/acph-2021-0015
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author Quijia Christian Rafael
Araujo Victor Hugo
Chorilli Marlus
author_facet Quijia Christian Rafael
Araujo Victor Hugo
Chorilli Marlus
author_sort Quijia Christian Rafael
collection DOAJ
description Piperine (PIP) is an alkaloid present in several species of piper, mainly Piper nigrum Linn. and P. longum, among other species. The present article provides a comprehensive review of PIP research in the last years concerning its chemical properties, synthesis, absorption, metabolism, bioavailability and toxicity. The reviewed PIP literature has shown many pharmacological properties, such as antidiabetic, antidiarrheal, antioxidant, antibacterial, and anti-parasitic activity of PIP. However, its low solubility and absorption make its application challenging. This review also includes advances in the development of nanosystems containing PIP, including liposomes, micelles, metal nanoparticles, nanofibers, polymeric nanoparticles, and solid-lipid nanoparticles. Finally, we discuss different in vitro and in vivo studies to evaluate the biological activity of this drug, as well as some methods for the synthesis of nanosystems and their physical characteristics.
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publishDate 2021-06-01
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series Acta Pharmaceutica
spelling doaj-art-47cfb5e6b7144ca8b463f73d7e0b17c82025-02-02T17:48:08ZengSciendoActa Pharmaceutica1846-95582021-06-0171218521310.2478/acph-2021-0015acph-2021-0015Piperine: Chemical, biological and nanotechnological applicationsQuijia Christian Rafael0Araujo Victor Hugo1Chorilli Marlus2São Paulo State University (UNESP), School of Pharmaceutical Sciences, Department of Drugs and Medicines, Araraquara, São Paulo, BrazilSão Paulo State University (UNESP), School of Pharmaceutical Sciences, Department of Drugs and Medicines, Araraquara, São Paulo, BrazilSão Paulo State University (UNESP), School of Pharmaceutical Sciences, Department of Drugs and Medicines, Araraquara, São Paulo, BrazilPiperine (PIP) is an alkaloid present in several species of piper, mainly Piper nigrum Linn. and P. longum, among other species. The present article provides a comprehensive review of PIP research in the last years concerning its chemical properties, synthesis, absorption, metabolism, bioavailability and toxicity. The reviewed PIP literature has shown many pharmacological properties, such as antidiabetic, antidiarrheal, antioxidant, antibacterial, and anti-parasitic activity of PIP. However, its low solubility and absorption make its application challenging. This review also includes advances in the development of nanosystems containing PIP, including liposomes, micelles, metal nanoparticles, nanofibers, polymeric nanoparticles, and solid-lipid nanoparticles. Finally, we discuss different in vitro and in vivo studies to evaluate the biological activity of this drug, as well as some methods for the synthesis of nanosystems and their physical characteristics.https://doi.org/10.2478/acph-2021-0015absorptionmetabolismpharmacological activitynanosystems
spellingShingle Quijia Christian Rafael
Araujo Victor Hugo
Chorilli Marlus
Piperine: Chemical, biological and nanotechnological applications
Acta Pharmaceutica
absorption
metabolism
pharmacological activity
nanosystems
title Piperine: Chemical, biological and nanotechnological applications
title_full Piperine: Chemical, biological and nanotechnological applications
title_fullStr Piperine: Chemical, biological and nanotechnological applications
title_full_unstemmed Piperine: Chemical, biological and nanotechnological applications
title_short Piperine: Chemical, biological and nanotechnological applications
title_sort piperine chemical biological and nanotechnological applications
topic absorption
metabolism
pharmacological activity
nanosystems
url https://doi.org/10.2478/acph-2021-0015
work_keys_str_mv AT quijiachristianrafael piperinechemicalbiologicalandnanotechnologicalapplications
AT araujovictorhugo piperinechemicalbiologicalandnanotechnologicalapplications
AT chorillimarlus piperinechemicalbiologicalandnanotechnologicalapplications