Piperine: Chemical, biological and nanotechnological applications
Piperine (PIP) is an alkaloid present in several species of piper, mainly Piper nigrum Linn. and P. longum, among other species. The present article provides a comprehensive review of PIP research in the last years concerning its chemical properties, synthesis, absorption, metabolism, bioavailabilit...
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| Format: | Article |
| Language: | English |
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Sciendo
2021-06-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2021-0015 |
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| author | Quijia Christian Rafael Araujo Victor Hugo Chorilli Marlus |
| author_facet | Quijia Christian Rafael Araujo Victor Hugo Chorilli Marlus |
| author_sort | Quijia Christian Rafael |
| collection | DOAJ |
| description | Piperine (PIP) is an alkaloid present in several species of piper, mainly Piper nigrum Linn. and P. longum, among other species. The present article provides a comprehensive review of PIP research in the last years concerning its chemical properties, synthesis, absorption, metabolism, bioavailability and toxicity. The reviewed PIP literature has shown many pharmacological properties, such as antidiabetic, antidiarrheal, antioxidant, antibacterial, and anti-parasitic activity of PIP. However, its low solubility and absorption make its application challenging. This review also includes advances in the development of nanosystems containing PIP, including liposomes, micelles, metal nanoparticles, nanofibers, polymeric nanoparticles, and solid-lipid nanoparticles. Finally, we discuss different in vitro and in vivo studies to evaluate the biological activity of this drug, as well as some methods for the synthesis of nanosystems and their physical characteristics. |
| format | Article |
| id | doaj-art-47cfb5e6b7144ca8b463f73d7e0b17c8 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2021-06-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-47cfb5e6b7144ca8b463f73d7e0b17c82025-02-02T17:48:08ZengSciendoActa Pharmaceutica1846-95582021-06-0171218521310.2478/acph-2021-0015acph-2021-0015Piperine: Chemical, biological and nanotechnological applicationsQuijia Christian Rafael0Araujo Victor Hugo1Chorilli Marlus2São Paulo State University (UNESP), School of Pharmaceutical Sciences, Department of Drugs and Medicines, Araraquara, São Paulo, BrazilSão Paulo State University (UNESP), School of Pharmaceutical Sciences, Department of Drugs and Medicines, Araraquara, São Paulo, BrazilSão Paulo State University (UNESP), School of Pharmaceutical Sciences, Department of Drugs and Medicines, Araraquara, São Paulo, BrazilPiperine (PIP) is an alkaloid present in several species of piper, mainly Piper nigrum Linn. and P. longum, among other species. The present article provides a comprehensive review of PIP research in the last years concerning its chemical properties, synthesis, absorption, metabolism, bioavailability and toxicity. The reviewed PIP literature has shown many pharmacological properties, such as antidiabetic, antidiarrheal, antioxidant, antibacterial, and anti-parasitic activity of PIP. However, its low solubility and absorption make its application challenging. This review also includes advances in the development of nanosystems containing PIP, including liposomes, micelles, metal nanoparticles, nanofibers, polymeric nanoparticles, and solid-lipid nanoparticles. Finally, we discuss different in vitro and in vivo studies to evaluate the biological activity of this drug, as well as some methods for the synthesis of nanosystems and their physical characteristics.https://doi.org/10.2478/acph-2021-0015absorptionmetabolismpharmacological activitynanosystems |
| spellingShingle | Quijia Christian Rafael Araujo Victor Hugo Chorilli Marlus Piperine: Chemical, biological and nanotechnological applications Acta Pharmaceutica absorption metabolism pharmacological activity nanosystems |
| title | Piperine: Chemical, biological and nanotechnological applications |
| title_full | Piperine: Chemical, biological and nanotechnological applications |
| title_fullStr | Piperine: Chemical, biological and nanotechnological applications |
| title_full_unstemmed | Piperine: Chemical, biological and nanotechnological applications |
| title_short | Piperine: Chemical, biological and nanotechnological applications |
| title_sort | piperine chemical biological and nanotechnological applications |
| topic | absorption metabolism pharmacological activity nanosystems |
| url | https://doi.org/10.2478/acph-2021-0015 |
| work_keys_str_mv | AT quijiachristianrafael piperinechemicalbiologicalandnanotechnologicalapplications AT araujovictorhugo piperinechemicalbiologicalandnanotechnologicalapplications AT chorillimarlus piperinechemicalbiologicalandnanotechnologicalapplications |