Digital health technologies in the accelerating medicines Partnership® Schizophrenia Program

Abstract Although meta-analytic studies have shown that 25-33% of those at Clinical High Risk (CHR) for psychosis transition to a first episode of psychosis within three years, less is known about estimating the risk of transition at an individual level. Digital phenotyping offers a novel approach t...

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Main Authors: Johanna T. W. Wigman, Ann Ee Ching, Yoonho Chung, Habiballah Rahimi Eichi, Erlend Lane, Carsten Langholm, Aditya Vaidyam, Andrew Jin Soo Byun, Anastasia Haidar, Jessica Hartmann, Angela Nunez, Dominic Dwyer, Adibah Amani Nasarudin, Owen Borders, Isabelle Scott, Zailyn Tamayo, Priya Matneja, Kang-Ik Cho, Jean Addington, Luis K. Alameda, Celso Arango, Nicholas J. K. Breitborde, Matthew R. Broome, Kristin S. Cadenhead, Monica E. Calkins, Eric Yu Hai Chen, Jimmy Choi, Philippe Conus, Cheryl M. Corcoran, Barbara A. Cornblatt, Covadonga M. Diaz-Caneja, Lauren M. Ellman, Paolo Fusar-Poli, Pablo A. Gaspar, Carla Gerber, Louise Birkedal Glenthøj, Leslie E. Horton, Christy Lai Ming Hui, Joseph Kambeitz, Lana Kambeitz-Ilankovic, Matcheri S. Keshavan, Sung-Wan Kim, Nikolaos Koutsouleris, Kerstin Langbein, Daniel Mamah, Daniel H. Mathalon, Vijay A. Mittal, Merete Nordentoft, Godfrey D. Pearlson, Jesus Perez, Diana O. Perkins, Albert R. Powers, Jack Rogers, Fred W. Sabb, Jason Schiffman, Jai L. Shah, Steven M. Silverstein, Stefan Smesny, Walid Yassin, William S. Stone, Gregory P. Strauss, Judy L. Thompson, Rachel Upthegrove, Swapna Verma, Jijun Wang, Daniel H. Wolf, Phillip Wolff, Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ), Laura M. Rowland, Simon D’Alfonso, Ofer Pasternak, Sylvain Bouix, Patrick D. McGorry, Rene S. Kahn, John M. Kane, Carrie E. Bearden, Scott W. Woods, Martha E. Shenton, Barnaby Nelson, Justin T. Baker, John Torous
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Schizophrenia
Online Access:https://doi.org/10.1038/s41537-025-00599-w
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author Johanna T. W. Wigman
Ann Ee Ching
Yoonho Chung
Habiballah Rahimi Eichi
Erlend Lane
Carsten Langholm
Aditya Vaidyam
Andrew Jin Soo Byun
Anastasia Haidar
Jessica Hartmann
Angela Nunez
Dominic Dwyer
Adibah Amani Nasarudin
Owen Borders
Isabelle Scott
Zailyn Tamayo
Priya Matneja
Kang-Ik Cho
Jean Addington
Luis K. Alameda
Celso Arango
Nicholas J. K. Breitborde
Matthew R. Broome
Kristin S. Cadenhead
Monica E. Calkins
Eric Yu Hai Chen
Jimmy Choi
Philippe Conus
Cheryl M. Corcoran
Barbara A. Cornblatt
Covadonga M. Diaz-Caneja
Lauren M. Ellman
Paolo Fusar-Poli
Pablo A. Gaspar
Carla Gerber
Louise Birkedal Glenthøj
Leslie E. Horton
Christy Lai Ming Hui
Joseph Kambeitz
Lana Kambeitz-Ilankovic
Matcheri S. Keshavan
Sung-Wan Kim
Nikolaos Koutsouleris
Kerstin Langbein
Daniel Mamah
Daniel H. Mathalon
Vijay A. Mittal
Merete Nordentoft
Godfrey D. Pearlson
Jesus Perez
Diana O. Perkins
Albert R. Powers
Jack Rogers
Fred W. Sabb
Jason Schiffman
Jai L. Shah
Steven M. Silverstein
Stefan Smesny
Walid Yassin
William S. Stone
Gregory P. Strauss
Judy L. Thompson
Rachel Upthegrove
Swapna Verma
Jijun Wang
Daniel H. Wolf
Phillip Wolff
Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ)
Laura M. Rowland
Simon D’Alfonso
Ofer Pasternak
Sylvain Bouix
Patrick D. McGorry
Rene S. Kahn
John M. Kane
Carrie E. Bearden
Scott W. Woods
Martha E. Shenton
Barnaby Nelson
Justin T. Baker
John Torous
author_facet Johanna T. W. Wigman
Ann Ee Ching
Yoonho Chung
Habiballah Rahimi Eichi
Erlend Lane
Carsten Langholm
Aditya Vaidyam
Andrew Jin Soo Byun
Anastasia Haidar
Jessica Hartmann
Angela Nunez
Dominic Dwyer
Adibah Amani Nasarudin
Owen Borders
Isabelle Scott
Zailyn Tamayo
Priya Matneja
Kang-Ik Cho
Jean Addington
Luis K. Alameda
Celso Arango
Nicholas J. K. Breitborde
Matthew R. Broome
Kristin S. Cadenhead
Monica E. Calkins
Eric Yu Hai Chen
Jimmy Choi
Philippe Conus
Cheryl M. Corcoran
Barbara A. Cornblatt
Covadonga M. Diaz-Caneja
Lauren M. Ellman
Paolo Fusar-Poli
Pablo A. Gaspar
Carla Gerber
Louise Birkedal Glenthøj
Leslie E. Horton
Christy Lai Ming Hui
Joseph Kambeitz
Lana Kambeitz-Ilankovic
Matcheri S. Keshavan
Sung-Wan Kim
Nikolaos Koutsouleris
Kerstin Langbein
Daniel Mamah
Daniel H. Mathalon
Vijay A. Mittal
Merete Nordentoft
Godfrey D. Pearlson
Jesus Perez
Diana O. Perkins
Albert R. Powers
Jack Rogers
Fred W. Sabb
Jason Schiffman
Jai L. Shah
Steven M. Silverstein
Stefan Smesny
Walid Yassin
William S. Stone
Gregory P. Strauss
Judy L. Thompson
Rachel Upthegrove
Swapna Verma
Jijun Wang
Daniel H. Wolf
Phillip Wolff
Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ)
Laura M. Rowland
Simon D’Alfonso
Ofer Pasternak
Sylvain Bouix
Patrick D. McGorry
Rene S. Kahn
John M. Kane
Carrie E. Bearden
Scott W. Woods
Martha E. Shenton
Barnaby Nelson
Justin T. Baker
John Torous
author_sort Johanna T. W. Wigman
collection DOAJ
description Abstract Although meta-analytic studies have shown that 25-33% of those at Clinical High Risk (CHR) for psychosis transition to a first episode of psychosis within three years, less is known about estimating the risk of transition at an individual level. Digital phenotyping offers a novel approach to explore the nature of CHR and may help to improve personalized risk prediction. Specifically, digital data enable detailed mapping of experiences, moods and behaviors during longer periods of time (e.g., weeks, months) and offer more insight into patterns over time at the individual level across their routine daily life. However, while novel digital health technologies open up many new avenues of research, they also come with specific challenges, including replicability of results and the adherence of participants. This paper outlines the design of the digital component of the Accelerating Medicines Partnership® Schizophrenia Program (AMP SCZ) project, a large international collaborative project that follows individuals at CHR for psychosis over a period of two years. The digital component comprises one-year smartphone-based digital phenotyping and actigraphy. Smartphone-based digital phenotyping includes 30-item short daily self-report surveys and voice diaries as well as passive data capture (geolocation, on/off screen state, and accelerometer). Actigraphy data are collected via an Axivity wristwatch. The aim of this paper is to describe the design and the three goals of the digital measures used in AMP SCZ to: (i) better understand the symptoms, real-life experiences, and behaviors of those at CHR for psychosis, (ii) improve the prediction of transition to psychosis and other health outcomes in this population based on digital phenotyping and, (iii) serve as an example for replicable and ethical research across geographically diverse regions and cultures. Accordingly, we describe the rationale, protocol and implementation of these digital components of the AMP SCZ project. **Link to video interview: https://vimeo.com/1060935583 **
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spelling doaj-art-47cc7cf97af44f929e85ef9ca6fa098d2025-08-20T02:05:41ZengNature PortfolioSchizophrenia2754-69932025-06-0111111010.1038/s41537-025-00599-wDigital health technologies in the accelerating medicines Partnership® Schizophrenia ProgramJohanna T. W. Wigman0Ann Ee Ching1Yoonho Chung2Habiballah Rahimi Eichi3Erlend Lane4Carsten Langholm5Aditya Vaidyam6Andrew Jin Soo Byun7Anastasia Haidar8Jessica Hartmann9Angela Nunez10Dominic Dwyer11Adibah Amani Nasarudin12Owen Borders13Isabelle Scott14Zailyn Tamayo15Priya Matneja16Kang-Ik Cho17Jean Addington18Luis K. Alameda19Celso Arango20Nicholas J. K. Breitborde21Matthew R. Broome22Kristin S. Cadenhead23Monica E. Calkins24Eric Yu Hai Chen25Jimmy Choi26Philippe Conus27Cheryl M. Corcoran28Barbara A. Cornblatt29Covadonga M. Diaz-Caneja30Lauren M. Ellman31Paolo Fusar-Poli32Pablo A. Gaspar33Carla Gerber34Louise Birkedal Glenthøj35Leslie E. Horton36Christy Lai Ming Hui37Joseph Kambeitz38Lana Kambeitz-Ilankovic39Matcheri S. Keshavan40Sung-Wan Kim41Nikolaos Koutsouleris42Kerstin Langbein43Daniel Mamah44Daniel H. Mathalon45Vijay A. Mittal46Merete Nordentoft47Godfrey D. Pearlson48Jesus Perez49Diana O. Perkins50Albert R. Powers51Jack Rogers52Fred W. Sabb53Jason Schiffman54Jai L. Shah55Steven M. Silverstein56Stefan Smesny57Walid Yassin58William S. Stone59Gregory P. Strauss60Judy L. Thompson61Rachel Upthegrove62Swapna Verma63Jijun Wang64Daniel H. Wolf65Phillip Wolff66Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ)Laura M. Rowland67Simon D’Alfonso68Ofer Pasternak69Sylvain Bouix70Patrick D. McGorry71Rene S. Kahn72John M. Kane73Carrie E. Bearden74Scott W. Woods75Martha E. Shenton76Barnaby Nelson77Justin T. Baker78John Torous79University of Groningen, University Medical Center Groningen, Department of Psychiatry, Interdisciplinary Centre of Psychopathology and Emotion regulationCentre for Youth Mental Health, The University of MelbourneMcLean HospitalMcLean HospitalBeth Israel Deaconess Medical Center, Harvard Medical SchoolBeth Israel Deaconess Medical Center, Harvard Medical SchoolBeth Israel Deaconess Medical Center, Harvard Medical SchoolBeth Israel Deaconess Medical Center, Harvard Medical SchoolBrigham and Women’s Hospital, Harvard Medical SchoolOrygenYale UniversityCentre for Youth Mental Health, The University of MelbourneCentre for Youth Mental Health, The University of MelbourneBrigham and Women’s Hospital, Harvard Medical SchoolCentre for Youth Mental Health, The University of MelbourneYale UniversityNorthwell HealthHarvard Medical SchoolDepartment of Psychiatry, Hotchkiss Brain Institute, University of CalgaryService de Psychiatrie Générale Dép. de Psychiatrie CHUV LausanneDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), CIBERSAM, ISCIII, School of Medicine, Universidad ComplutenseDepartment of Psychiatry and Behavioral Health, Ohio State UniversityInstitute for Mental Health, School of Psychology, University of BirminghamUniversity of CaliforniaDepartment of Psychiatry, Perelman School of Medicine, University of PennsylvaniaDepartment of Psychiatry, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, University of Hong KongOlin Neuropsychiatry Research Center, Hartford HealthCare Behavioral Health NetworkService de Psychiatrie Générale Dép. de Psychiatrie CHUV LausanneDepartment of Psychiatry, Icahn School of Medicine at Mount SinaiDepartment of Psychiatry, Donald and Barbara Zucker School of MedicineDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), CIBERSAM, ISCIII, School of Medicine, Universidad ComplutenseDepartment of Psychology & Neuroscience, Temple UniversityDepartment of Psychosis Studies, King’s College LondonDepartment of Psychiatry, IMHAY, University of ChileBehavioral Health Services, PeaceHealth Medical GroupCopenhagen Research Centre for Mental Health, Mental Health Copenhagen, Department of Psychology, University of CopenhagenDepartment of Psychiatry, University of Pittsburgh School of MedicineDepartment of Psychiatry, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, University of Hong KongDepartment of Psychiatry, Faculty of Medicine and University Hospital Cologne, University of CologneDepartment of Psychiatry, Faculty of Medicine and University Hospital Cologne, University of CologneHarvard Medical SchoolDepartment of Psychiatry, Chonnam National University Medical SchoolDepartment of Psychosis Studies, King’s College LondonDepartment of Psychiatry and Psychotherapy, Jena University HospitalDepartment of Psychiatry, Washington University School of MedicineDepartment of Psychiatry and Behavioral Sciences and Weill Institute for Neurosciences, University of California, San FranciscoDepartment of Psychology, Northwestern UniversityMental Health Services in the Capital RegionOlin Neuropsychiatry Research Center, Institute of Living, Hartford HospitalMcLean HospitalDepartment of Psychiatry, University of North CarolinaYale UniversityCentre for Human Brain Health, University of BirminghamDepartment of Psychiatry, University of ChileDepartment of Psychological Science, University of CaliforniaPEPP-Montreal, Douglas Research Centre, MontrealDepartment of Psychiatry, University of Rochester Medical CenterDepartment of Psychiatry and Psychotherapy, Jena University HospitalHarvard Medical SchoolHarvard Medical SchoolDepartment of Psychology, University of GeorgiaDepartment of Psychiatry, University of Rochester Medical Center, RochesterInstitute for Mental Health, School of Psychology, University of BirminghamInstitute of Mental HealthShanghai Mental Health Center, Shanghai Jiaotong University School of MedicineDepartment of Psychiatry, Perelman School of Medicine, University of PennsylvaniaDepartment of Psychology, Emory UniversityNational Institute of Mental HealthSchool of Computing and Information Systems, The University of MelbourneBrigham and Women’s Hospital, Harvard Medical SchoolBrigham and Women’s Hospital, Harvard Medical SchoolCentre for Youth Mental Health, The University of MelbourneDepartment of Psychiatry, Icahn School of Medicine at Mount SinaiDepartment of Psychiatry, Donald and Barbara Zucker School of MedicineDepartments of Psychiatry and Biobehavioral Sciences & Psychology, Semel Institute for Neuroscience and Human Behavior, University of CaliforniaYale UniversityHarvard Medical SchoolCentre for Youth Mental Health, The University of MelbourneMcLean HospitalHarvard Medical SchoolAbstract Although meta-analytic studies have shown that 25-33% of those at Clinical High Risk (CHR) for psychosis transition to a first episode of psychosis within three years, less is known about estimating the risk of transition at an individual level. Digital phenotyping offers a novel approach to explore the nature of CHR and may help to improve personalized risk prediction. Specifically, digital data enable detailed mapping of experiences, moods and behaviors during longer periods of time (e.g., weeks, months) and offer more insight into patterns over time at the individual level across their routine daily life. However, while novel digital health technologies open up many new avenues of research, they also come with specific challenges, including replicability of results and the adherence of participants. This paper outlines the design of the digital component of the Accelerating Medicines Partnership® Schizophrenia Program (AMP SCZ) project, a large international collaborative project that follows individuals at CHR for psychosis over a period of two years. The digital component comprises one-year smartphone-based digital phenotyping and actigraphy. Smartphone-based digital phenotyping includes 30-item short daily self-report surveys and voice diaries as well as passive data capture (geolocation, on/off screen state, and accelerometer). Actigraphy data are collected via an Axivity wristwatch. The aim of this paper is to describe the design and the three goals of the digital measures used in AMP SCZ to: (i) better understand the symptoms, real-life experiences, and behaviors of those at CHR for psychosis, (ii) improve the prediction of transition to psychosis and other health outcomes in this population based on digital phenotyping and, (iii) serve as an example for replicable and ethical research across geographically diverse regions and cultures. Accordingly, we describe the rationale, protocol and implementation of these digital components of the AMP SCZ project. **Link to video interview: https://vimeo.com/1060935583 **https://doi.org/10.1038/s41537-025-00599-w
spellingShingle Johanna T. W. Wigman
Ann Ee Ching
Yoonho Chung
Habiballah Rahimi Eichi
Erlend Lane
Carsten Langholm
Aditya Vaidyam
Andrew Jin Soo Byun
Anastasia Haidar
Jessica Hartmann
Angela Nunez
Dominic Dwyer
Adibah Amani Nasarudin
Owen Borders
Isabelle Scott
Zailyn Tamayo
Priya Matneja
Kang-Ik Cho
Jean Addington
Luis K. Alameda
Celso Arango
Nicholas J. K. Breitborde
Matthew R. Broome
Kristin S. Cadenhead
Monica E. Calkins
Eric Yu Hai Chen
Jimmy Choi
Philippe Conus
Cheryl M. Corcoran
Barbara A. Cornblatt
Covadonga M. Diaz-Caneja
Lauren M. Ellman
Paolo Fusar-Poli
Pablo A. Gaspar
Carla Gerber
Louise Birkedal Glenthøj
Leslie E. Horton
Christy Lai Ming Hui
Joseph Kambeitz
Lana Kambeitz-Ilankovic
Matcheri S. Keshavan
Sung-Wan Kim
Nikolaos Koutsouleris
Kerstin Langbein
Daniel Mamah
Daniel H. Mathalon
Vijay A. Mittal
Merete Nordentoft
Godfrey D. Pearlson
Jesus Perez
Diana O. Perkins
Albert R. Powers
Jack Rogers
Fred W. Sabb
Jason Schiffman
Jai L. Shah
Steven M. Silverstein
Stefan Smesny
Walid Yassin
William S. Stone
Gregory P. Strauss
Judy L. Thompson
Rachel Upthegrove
Swapna Verma
Jijun Wang
Daniel H. Wolf
Phillip Wolff
Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ)
Laura M. Rowland
Simon D’Alfonso
Ofer Pasternak
Sylvain Bouix
Patrick D. McGorry
Rene S. Kahn
John M. Kane
Carrie E. Bearden
Scott W. Woods
Martha E. Shenton
Barnaby Nelson
Justin T. Baker
John Torous
Digital health technologies in the accelerating medicines Partnership® Schizophrenia Program
Schizophrenia
title Digital health technologies in the accelerating medicines Partnership® Schizophrenia Program
title_full Digital health technologies in the accelerating medicines Partnership® Schizophrenia Program
title_fullStr Digital health technologies in the accelerating medicines Partnership® Schizophrenia Program
title_full_unstemmed Digital health technologies in the accelerating medicines Partnership® Schizophrenia Program
title_short Digital health technologies in the accelerating medicines Partnership® Schizophrenia Program
title_sort digital health technologies in the accelerating medicines partnership r schizophrenia program
url https://doi.org/10.1038/s41537-025-00599-w
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