Functions and mechanisms of non-histone post-translational modifications in cancer progression
Abstract Protein post-translational modifications (PTMs) refer to covalent and enzymatic alterations to folded or nascent proteins during or after protein biosynthesis to alter the properties and functions of proteins. PTMs are modified in a variety of types and affect almost all aspects of cell bio...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2025-03-01
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| Series: | Cell Death Discovery |
| Online Access: | https://doi.org/10.1038/s41420-025-02410-2 |
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| _version_ | 1850154036949417984 |
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| author | Zongyang Li Tao Zhu Yushu Wu Yongbo Yu Yunjiang Zang Lebo Yu Zhilei Zhang |
| author_facet | Zongyang Li Tao Zhu Yushu Wu Yongbo Yu Yunjiang Zang Lebo Yu Zhilei Zhang |
| author_sort | Zongyang Li |
| collection | DOAJ |
| description | Abstract Protein post-translational modifications (PTMs) refer to covalent and enzymatic alterations to folded or nascent proteins during or after protein biosynthesis to alter the properties and functions of proteins. PTMs are modified in a variety of types and affect almost all aspects of cell biology. PTMs have been reported to be involved in cancer progression by influencing multiple signaling pathways. The mechanism of action of histone PTMs in cancer has been extensively studied. Notably, evidence is mounting that PTMs of non-histone proteins also play a vital role in cancer progression. In this review, we provide a systematic description of main non-histone PTMs associated with cancer progression, including acetylation, lactylation, methylation, ubiquitination, phosphorylation, and SUMOylation, based on recent studies. |
| format | Article |
| id | doaj-art-47c751ddf723496a8a414d4f416fccaf |
| institution | OA Journals |
| issn | 2058-7716 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death Discovery |
| spelling | doaj-art-47c751ddf723496a8a414d4f416fccaf2025-08-20T02:25:34ZengNature Publishing GroupCell Death Discovery2058-77162025-03-0111111010.1038/s41420-025-02410-2Functions and mechanisms of non-histone post-translational modifications in cancer progressionZongyang Li0Tao Zhu1Yushu Wu2Yongbo Yu3Yunjiang Zang4Lebo Yu5Zhilei Zhang6Department of Urology, The First Affiliated Hospital of Shandong Second Medical UniversityDepartment of Urology, The First Affiliated Hospital of Shandong Second Medical UniversitySchool of Clinical Medicine, Shandong Second Medical UniversityDepartment of Urology, The First Affiliated Hospital of Shandong Second Medical UniversityDepartment of Urology, The First Affiliated Hospital of Shandong Second Medical UniversityDepartment of Urology, The First Affiliated Hospital of Shandong Second Medical UniversityDepartment of Urology, The First Affiliated Hospital of Shandong Second Medical UniversityAbstract Protein post-translational modifications (PTMs) refer to covalent and enzymatic alterations to folded or nascent proteins during or after protein biosynthesis to alter the properties and functions of proteins. PTMs are modified in a variety of types and affect almost all aspects of cell biology. PTMs have been reported to be involved in cancer progression by influencing multiple signaling pathways. The mechanism of action of histone PTMs in cancer has been extensively studied. Notably, evidence is mounting that PTMs of non-histone proteins also play a vital role in cancer progression. In this review, we provide a systematic description of main non-histone PTMs associated with cancer progression, including acetylation, lactylation, methylation, ubiquitination, phosphorylation, and SUMOylation, based on recent studies.https://doi.org/10.1038/s41420-025-02410-2 |
| spellingShingle | Zongyang Li Tao Zhu Yushu Wu Yongbo Yu Yunjiang Zang Lebo Yu Zhilei Zhang Functions and mechanisms of non-histone post-translational modifications in cancer progression Cell Death Discovery |
| title | Functions and mechanisms of non-histone post-translational modifications in cancer progression |
| title_full | Functions and mechanisms of non-histone post-translational modifications in cancer progression |
| title_fullStr | Functions and mechanisms of non-histone post-translational modifications in cancer progression |
| title_full_unstemmed | Functions and mechanisms of non-histone post-translational modifications in cancer progression |
| title_short | Functions and mechanisms of non-histone post-translational modifications in cancer progression |
| title_sort | functions and mechanisms of non histone post translational modifications in cancer progression |
| url | https://doi.org/10.1038/s41420-025-02410-2 |
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