Echocardiographic Findings in Patients with Atrial Septal Aneurysm: A Prospective Case-Control Study

Background. Atrial septal aneurysm (ASA) is a congenital deformity of the interatrial septum with a prevalence of 1-2% in the adult population. Although ASA has been supposed to be an incidental finding in echocardiographic examination, its structural and clinical associations have gained an increas...

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Main Authors: Ramazan Atak, Mehmet Ileri, Selcuk Ozturk, Ahmet Korkmaz, Ertan Yetkin
Format: Article
Language:English
Published: Wiley 2019-01-01
Series:Cardiology Research and Practice
Online Access:http://dx.doi.org/10.1155/2019/3215765
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author Ramazan Atak
Mehmet Ileri
Selcuk Ozturk
Ahmet Korkmaz
Ertan Yetkin
author_facet Ramazan Atak
Mehmet Ileri
Selcuk Ozturk
Ahmet Korkmaz
Ertan Yetkin
author_sort Ramazan Atak
collection DOAJ
description Background. Atrial septal aneurysm (ASA) is a congenital deformity of the interatrial septum with a prevalence of 1-2% in the adult population. Although ASA has been supposed to be an incidental finding in echocardiographic examination, its structural and clinical associations have gained an increasing interest. Aim. To investigate and compare the clinical features and echocardiographic parameters between ASA patients and age- and gender-matched control group patients. Methods. 410 patients with ASA were enrolled in the study, prospectively. After the exclusion of 33 patients, the remaining 377 patients comprised the study group. The control group consisted of 377 age- and gender-matched patients without ASA. Results. Aortic valve regurgitation and mitral valve regurgitation were more often observed in patients with ASA, and percentages of patients with ascending aortic aneurysm (AAA), patent foramen ovale (PFO), and atrial septal defect (ASD) were higher in ASA patients compared to control group patients. Aortic root diameter was larger in ASA patients compared to control group patients (29.2 ± 3.9, 28.6 ± 3.1, p=0.05, respectively). Ascending aorta diameter was higher in ASA patients compared to patients without ASA (44 ± 0.3, 41.5 ± 0.2, p=0.02). Logistic regression analysis revealed that mitral valve regurgitation (OR: 2.05, 95% CI : 1.44–2.92, p<0.001) and PFO (OR: 11.62, 95% CI : 2.64–51.02, p=0.001) were positively and independently associated with the presence of ASA. AAA tended to be statistically and independently associated with ASA (OR: 2.69, 95% CI : 0.97–7.47, p=0.05). Conclusions. We have demonstrated a higher incidence of mitral/aortic valvular regurgitations, AAA, PFO, and ASD in ASA patients compared to age- and gender-matched control group patients. In addition, we have shown that ASA is significantly and positively associated with mild mitral regurgitation and PFO.
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spelling doaj-art-47c62511bdb44d77a66867ff8e26c42c2025-02-03T01:02:21ZengWileyCardiology Research and Practice2090-80162090-05972019-01-01201910.1155/2019/32157653215765Echocardiographic Findings in Patients with Atrial Septal Aneurysm: A Prospective Case-Control StudyRamazan Atak0Mehmet Ileri1Selcuk Ozturk2Ahmet Korkmaz3Ertan Yetkin4Lokman Hekim Akay Hospital, Department of Cardiology, Ankara, TurkeyAnkara Numune Education and Research Hospital, Department of Cardiology, Ankara, TurkeyAnkara Education and Research Hospital, Department of Cardiology, Ankara, TurkeyAnkara Numune Education and Research Hospital, Department of Cardiology, Ankara, TurkeyIstinye University Liv Hospital, Department of Cardiology, Istanbul, TurkeyBackground. Atrial septal aneurysm (ASA) is a congenital deformity of the interatrial septum with a prevalence of 1-2% in the adult population. Although ASA has been supposed to be an incidental finding in echocardiographic examination, its structural and clinical associations have gained an increasing interest. Aim. To investigate and compare the clinical features and echocardiographic parameters between ASA patients and age- and gender-matched control group patients. Methods. 410 patients with ASA were enrolled in the study, prospectively. After the exclusion of 33 patients, the remaining 377 patients comprised the study group. The control group consisted of 377 age- and gender-matched patients without ASA. Results. Aortic valve regurgitation and mitral valve regurgitation were more often observed in patients with ASA, and percentages of patients with ascending aortic aneurysm (AAA), patent foramen ovale (PFO), and atrial septal defect (ASD) were higher in ASA patients compared to control group patients. Aortic root diameter was larger in ASA patients compared to control group patients (29.2 ± 3.9, 28.6 ± 3.1, p=0.05, respectively). Ascending aorta diameter was higher in ASA patients compared to patients without ASA (44 ± 0.3, 41.5 ± 0.2, p=0.02). Logistic regression analysis revealed that mitral valve regurgitation (OR: 2.05, 95% CI : 1.44–2.92, p<0.001) and PFO (OR: 11.62, 95% CI : 2.64–51.02, p=0.001) were positively and independently associated with the presence of ASA. AAA tended to be statistically and independently associated with ASA (OR: 2.69, 95% CI : 0.97–7.47, p=0.05). Conclusions. We have demonstrated a higher incidence of mitral/aortic valvular regurgitations, AAA, PFO, and ASD in ASA patients compared to age- and gender-matched control group patients. In addition, we have shown that ASA is significantly and positively associated with mild mitral regurgitation and PFO.http://dx.doi.org/10.1155/2019/3215765
spellingShingle Ramazan Atak
Mehmet Ileri
Selcuk Ozturk
Ahmet Korkmaz
Ertan Yetkin
Echocardiographic Findings in Patients with Atrial Septal Aneurysm: A Prospective Case-Control Study
Cardiology Research and Practice
title Echocardiographic Findings in Patients with Atrial Septal Aneurysm: A Prospective Case-Control Study
title_full Echocardiographic Findings in Patients with Atrial Septal Aneurysm: A Prospective Case-Control Study
title_fullStr Echocardiographic Findings in Patients with Atrial Septal Aneurysm: A Prospective Case-Control Study
title_full_unstemmed Echocardiographic Findings in Patients with Atrial Septal Aneurysm: A Prospective Case-Control Study
title_short Echocardiographic Findings in Patients with Atrial Septal Aneurysm: A Prospective Case-Control Study
title_sort echocardiographic findings in patients with atrial septal aneurysm a prospective case control study
url http://dx.doi.org/10.1155/2019/3215765
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AT mehmetileri echocardiographicfindingsinpatientswithatrialseptalaneurysmaprospectivecasecontrolstudy
AT selcukozturk echocardiographicfindingsinpatientswithatrialseptalaneurysmaprospectivecasecontrolstudy
AT ahmetkorkmaz echocardiographicfindingsinpatientswithatrialseptalaneurysmaprospectivecasecontrolstudy
AT ertanyetkin echocardiographicfindingsinpatientswithatrialseptalaneurysmaprospectivecasecontrolstudy