Ulcerative colitis combined with isolated superficially serrated adenoma: a Case Report
IntroductionSuperficially serrated adenoma (SuSA) is a recently identified type of serrated lesion characterized by a combination of adenomatous and serrated features. There are limited reports on SuSA currently, and its occurrence in conjunction with ulcerative colitis (UC) has not yet been documen...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1576166/full |
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| author | Hua Gao Jinshan Nie Lipin Zhang Chen Gong |
| author_facet | Hua Gao Jinshan Nie Lipin Zhang Chen Gong |
| author_sort | Hua Gao |
| collection | DOAJ |
| description | IntroductionSuperficially serrated adenoma (SuSA) is a recently identified type of serrated lesion characterized by a combination of adenomatous and serrated features. There are limited reports on SuSA currently, and its occurrence in conjunction with ulcerative colitis (UC) has not yet been documented.Case presentationWe present the case of a 38-year-old male with a 13-year history of ulcerative colitis (UC). During a routine follow-up colonoscopy, a superficial elevated lesion with a whitish surface was detected in the rectum, 10 cm from the anal verge. The lesion was removed en bloc via endoscopic submucosal dissection (ESD). Pathological analysis showed a combination of superficial serrated and vertically oriented adenomatoid glands. Immunohistochemistry indicated that the superficial epithelial cells exhibited serrated features and expressed CK20, while the middle and lower mucosal layers tested positive for Ki-67.ConclusionAlthough some studies have explored SuSA, many aspects of the disease remain unclear. This is the first reported case of UC combined with SuSA. Future reports are essential to enhance understanding of the potential link between UC and SuSA. |
| format | Article |
| id | doaj-art-47c26a99a6794ab9a80f61d59842a863 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-47c26a99a6794ab9a80f61d59842a8632025-08-20T03:45:18ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-06-011510.3389/fonc.2025.15761661576166Ulcerative colitis combined with isolated superficially serrated adenoma: a Case ReportHua Gao0Jinshan Nie1Lipin Zhang2Chen Gong3Department of Gastroenterology, Taicang Affiliated Hospital of Soochow University, The First People’s Hospital of Taicang, Taicang, Jiangsu, ChinaDepartment of Gastroenterology, Taicang Affiliated Hospital of Soochow University, The First People’s Hospital of Taicang, Taicang, Jiangsu, ChinaDepartment of Pathology, Taicang Affiliated Hospital of Soochow University, The First People’s Hospital of Taicang, Taicang, Jiangsu, ChinaDepartment of Gastroenterology, Taicang Affiliated Hospital of Soochow University, The First People’s Hospital of Taicang, Taicang, Jiangsu, ChinaIntroductionSuperficially serrated adenoma (SuSA) is a recently identified type of serrated lesion characterized by a combination of adenomatous and serrated features. There are limited reports on SuSA currently, and its occurrence in conjunction with ulcerative colitis (UC) has not yet been documented.Case presentationWe present the case of a 38-year-old male with a 13-year history of ulcerative colitis (UC). During a routine follow-up colonoscopy, a superficial elevated lesion with a whitish surface was detected in the rectum, 10 cm from the anal verge. The lesion was removed en bloc via endoscopic submucosal dissection (ESD). Pathological analysis showed a combination of superficial serrated and vertically oriented adenomatoid glands. Immunohistochemistry indicated that the superficial epithelial cells exhibited serrated features and expressed CK20, while the middle and lower mucosal layers tested positive for Ki-67.ConclusionAlthough some studies have explored SuSA, many aspects of the disease remain unclear. This is the first reported case of UC combined with SuSA. Future reports are essential to enhance understanding of the potential link between UC and SuSA.https://www.frontiersin.org/articles/10.3389/fonc.2025.1576166/fullsuperficial serrated adenomaulcerative colitisendoscopic resectionpathological diagnosiscase report |
| spellingShingle | Hua Gao Jinshan Nie Lipin Zhang Chen Gong Ulcerative colitis combined with isolated superficially serrated adenoma: a Case Report Frontiers in Oncology superficial serrated adenoma ulcerative colitis endoscopic resection pathological diagnosis case report |
| title | Ulcerative colitis combined with isolated superficially serrated adenoma: a Case Report |
| title_full | Ulcerative colitis combined with isolated superficially serrated adenoma: a Case Report |
| title_fullStr | Ulcerative colitis combined with isolated superficially serrated adenoma: a Case Report |
| title_full_unstemmed | Ulcerative colitis combined with isolated superficially serrated adenoma: a Case Report |
| title_short | Ulcerative colitis combined with isolated superficially serrated adenoma: a Case Report |
| title_sort | ulcerative colitis combined with isolated superficially serrated adenoma a case report |
| topic | superficial serrated adenoma ulcerative colitis endoscopic resection pathological diagnosis case report |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1576166/full |
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