Lysophosphatidic acid selectively modulates excitatory transmission in hippocampal neurons

Lysophosphatidic acid selectively modulates excitatory transmission in hippocampal neurons

Abstract Background Lysophosphatidic acid (LPA) is a bioactive phospholipid that affects hippocampal excitatory synaptic transmission. Results Here we provide in vitro evidence that LPA elicits intracellular calcium concentration ([Ca2+]i) transients by LPA2 receptor activation in primary cultured h...

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Bibliographic Details
Main Authors: Nicola Brandt, Arne Battefeld, Olga Suckau, Konstantin Stadler, Bhumika Singh, Pei Zhang, Junken Aoki, Jerold Chun, Christian Henneberger, Rosemarie Grantyn, Johannes Vogt, Robert Nitsch, Ulf Strauss, Anja U. Bräuer
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Cell & Bioscience
Subjects:
LPA
Calcium imaging
LPA2 receptor
mEPCS
Hippocampus
Neuron
Online Access:https://doi.org/10.1186/s13578-025-01458-y
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