Iron and Liver Diseases
A mild to moderate iron excess is found in patients with liver diseases apparently unrelated to genetic hemochromatosis. Iron appears to affect the natural history of hepatitis C virus-related chronic liver diseases, alcoholic liver disease and nonalcoholic steatohepatitis by leading to a more sever...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2000-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2000/954802 |
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| _version_ | 1850110180000268288 |
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| author | Silvia Fargion Michela Mattioli Anna Ludovica Fracanzani Gemino Fiorelli |
| author_facet | Silvia Fargion Michela Mattioli Anna Ludovica Fracanzani Gemino Fiorelli |
| author_sort | Silvia Fargion |
| collection | DOAJ |
| description | A
mild to moderate iron excess is found in patients with liver diseases
apparently unrelated to genetic hemochromatosis. Iron appears to
affect the natural history of hepatitis C virus-related chronic liver
diseases, alcoholic liver disease and nonalcoholic steatohepatitis
by leading to a more severe fibrosis and thus aiding the evolution
to cirrhosis.Ahigher frequency of mutations of the HFE gene, the
gene responsible for hereditary hemochromatosis, is found in patients
with liver diseases and increased liver iron than in normal
patients. Patients with excess iron are potentially at a higher risk
of developing hepatocellular carcinoma. Iron depletion therapy
could interfere with fibrosis development and possibly reduce the
risk of liver cancer occurrence. |
| format | Article |
| id | doaj-art-47bb287e9dfc44d9b31fc3996b6582b7 |
| institution | OA Journals |
| issn | 0835-7900 |
| language | English |
| publishDate | 2000-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-47bb287e9dfc44d9b31fc3996b6582b72025-08-20T02:37:53ZengWileyCanadian Journal of Gastroenterology0835-79002000-01-0114Suppl D89D92D10.1155/2000/954802Iron and Liver DiseasesSilvia Fargion0Michela Mattioli1Anna Ludovica Fracanzani2Gemino Fiorelli3Dipartimento di Medicina Interna, Università di Milano, Ospedale Maggiore IRCCS, Milano, ItalyDipartimento di Medicina Interna, Università di Milano, Ospedale Maggiore IRCCS, Milano, ItalyDipartimento di Medicina Interna, Università di Milano, Ospedale Maggiore IRCCS, Milano, ItalyDipartimento di Medicina Interna, Università di Milano, Ospedale Maggiore IRCCS, Milano, ItalyA mild to moderate iron excess is found in patients with liver diseases apparently unrelated to genetic hemochromatosis. Iron appears to affect the natural history of hepatitis C virus-related chronic liver diseases, alcoholic liver disease and nonalcoholic steatohepatitis by leading to a more severe fibrosis and thus aiding the evolution to cirrhosis.Ahigher frequency of mutations of the HFE gene, the gene responsible for hereditary hemochromatosis, is found in patients with liver diseases and increased liver iron than in normal patients. Patients with excess iron are potentially at a higher risk of developing hepatocellular carcinoma. Iron depletion therapy could interfere with fibrosis development and possibly reduce the risk of liver cancer occurrence.http://dx.doi.org/10.1155/2000/954802 |
| spellingShingle | Silvia Fargion Michela Mattioli Anna Ludovica Fracanzani Gemino Fiorelli Iron and Liver Diseases Canadian Journal of Gastroenterology |
| title | Iron and Liver Diseases |
| title_full | Iron and Liver Diseases |
| title_fullStr | Iron and Liver Diseases |
| title_full_unstemmed | Iron and Liver Diseases |
| title_short | Iron and Liver Diseases |
| title_sort | iron and liver diseases |
| url | http://dx.doi.org/10.1155/2000/954802 |
| work_keys_str_mv | AT silviafargion ironandliverdiseases AT michelamattioli ironandliverdiseases AT annaludovicafracanzani ironandliverdiseases AT geminofiorelli ironandliverdiseases |