Usefulness of Faecal Calprotectin Measurement in Children with Various Types of Inflammatory Bowel Disease
Introduction. The aim of the study was to assess the usefulness of the FC measurement in children with various types of IBD and relation to the disease activity. Patients and Methods. 91 patients (49 boys: 53.85% and 42 girls: 46.15%, mean age: 13.38 years, range 6–18 years) were included in the ana...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2012/608249 |
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| author | Marzena Komraus Halina Wos Sabina Wiecek Maciej Kajor Urszula Grzybowska-Chlebowczyk |
| author_facet | Marzena Komraus Halina Wos Sabina Wiecek Maciej Kajor Urszula Grzybowska-Chlebowczyk |
| author_sort | Marzena Komraus |
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| description | Introduction. The aim of the study was to assess the usefulness of the FC measurement in children with various types of IBD and relation to the disease activity. Patients and Methods. 91 patients (49 boys: 53.85% and 42 girls: 46.15%, mean age: 13.38 years, range 6–18 years) were included in the analysis. Patients were divided into the groups: B1—24 children with CD, B2—16 patients with UC, and a group comprising 31 children with other types of colitis; the control group (K) comprised 20 healthy children. FC was assayed by ELISA method, using Phical test (Calpro). Results. The mean faecal calprotectin concentrations were higher in children with CD and UC as compared to healthy controls, patients with eosinophilic, lymphocytic, and nonspecific colitis. A positive correlation was observed between FC concentrations and the disease activity (the PCDAI scale, the Truelove-Witts Scale, and the endoscopic Rachmilewitz Index). Conclusion. It seems that the FC concentrations can be a useful, safe, and noninvasive test in children suspected for IBD, since FC concentration is higher in children with CD and UC than in patients with other inflammatory diseases. |
| format | Article |
| id | doaj-art-47ba9461c9e149f8a259a5ae6eec8eec |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
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| series | Mediators of Inflammation |
| spelling | doaj-art-47ba9461c9e149f8a259a5ae6eec8eec2025-08-20T02:37:53ZengWileyMediators of Inflammation0962-93511466-18612012-01-01201210.1155/2012/608249608249Usefulness of Faecal Calprotectin Measurement in Children with Various Types of Inflammatory Bowel DiseaseMarzena Komraus0Halina Wos1Sabina Wiecek2Maciej Kajor3Urszula Grzybowska-Chlebowczyk4Department of Paediatrics, Medical University of Silesia, Medykow 16, 40-752 Katowice, PolandDepartment of Paediatrics, Medical University of Silesia, Medykow 16, 40-752 Katowice, PolandDepartment of Paediatrics, Medical University of Silesia, Medykow 16, 40-752 Katowice, PolandDepartment of Pathomorphology, Medical University of Silesia, 40-752 Katowice, PolandDepartment of Paediatrics, Medical University of Silesia, Medykow 16, 40-752 Katowice, PolandIntroduction. The aim of the study was to assess the usefulness of the FC measurement in children with various types of IBD and relation to the disease activity. Patients and Methods. 91 patients (49 boys: 53.85% and 42 girls: 46.15%, mean age: 13.38 years, range 6–18 years) were included in the analysis. Patients were divided into the groups: B1—24 children with CD, B2—16 patients with UC, and a group comprising 31 children with other types of colitis; the control group (K) comprised 20 healthy children. FC was assayed by ELISA method, using Phical test (Calpro). Results. The mean faecal calprotectin concentrations were higher in children with CD and UC as compared to healthy controls, patients with eosinophilic, lymphocytic, and nonspecific colitis. A positive correlation was observed between FC concentrations and the disease activity (the PCDAI scale, the Truelove-Witts Scale, and the endoscopic Rachmilewitz Index). Conclusion. It seems that the FC concentrations can be a useful, safe, and noninvasive test in children suspected for IBD, since FC concentration is higher in children with CD and UC than in patients with other inflammatory diseases.http://dx.doi.org/10.1155/2012/608249 |
| spellingShingle | Marzena Komraus Halina Wos Sabina Wiecek Maciej Kajor Urszula Grzybowska-Chlebowczyk Usefulness of Faecal Calprotectin Measurement in Children with Various Types of Inflammatory Bowel Disease Mediators of Inflammation |
| title | Usefulness of Faecal Calprotectin Measurement in Children with Various Types of Inflammatory Bowel Disease |
| title_full | Usefulness of Faecal Calprotectin Measurement in Children with Various Types of Inflammatory Bowel Disease |
| title_fullStr | Usefulness of Faecal Calprotectin Measurement in Children with Various Types of Inflammatory Bowel Disease |
| title_full_unstemmed | Usefulness of Faecal Calprotectin Measurement in Children with Various Types of Inflammatory Bowel Disease |
| title_short | Usefulness of Faecal Calprotectin Measurement in Children with Various Types of Inflammatory Bowel Disease |
| title_sort | usefulness of faecal calprotectin measurement in children with various types of inflammatory bowel disease |
| url | http://dx.doi.org/10.1155/2012/608249 |
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