Plasmapheresis for lowering the risks of placenta-associated complications in antiphospholipid syndrome
Aim: to study plasmapheresis (PP) effect on antiphospholipid syndrome (APS) treatment during preconception preparation and pregnancy.Materials and Methods. A single-center, prospective, randomized, uncontrolled study was conducted. A total of 137 women aged 22 to 32 years diagnosed with APS-related...
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| Format: | Article |
| Language: | Russian |
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IRBIS LLC
2025-03-01
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| Series: | Акушерство, гинекология и репродукция |
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| Online Access: | https://www.gynecology.su/jour/article/view/2346 |
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| author | N. F. Kuneshko V. V. Kim E. M. Lyadnova A. R. Metkina M. N. Velieva A. V. Lazarchuk V. O. Bitsadze M. V. Tretyakova D. V. Blinov |
| author_facet | N. F. Kuneshko V. V. Kim E. M. Lyadnova A. R. Metkina M. N. Velieva A. V. Lazarchuk V. O. Bitsadze M. V. Tretyakova D. V. Blinov |
| author_sort | N. F. Kuneshko |
| collection | DOAJ |
| description | Aim: to study plasmapheresis (PP) effect on antiphospholipid syndrome (APS) treatment during preconception preparation and pregnancy.Materials and Methods. A single-center, prospective, randomized, uncontrolled study was conducted. A total of 137 women aged 22 to 32 years diagnosed with APS-related habitual miscarriage were examined. The patients were stratified as follows: main group consisted of 73 patients underwent a PF course (7 procedures at preconception preparation stage); comparison group – 64 patients not underwent efferent therapy. Antiphospholipid antibodies (APA) circulation was determined by solid-phase immunofluorescence. PР was performed using an intermittent technique. The laboratory study included assessing titers of lupus anticoagulant (LA), anti-cardiolipin antibodies (aCL), anti-β2-glycoprotein 1 antibodies (anti-β2-GP1) and anti-annexin V antibodies (anti-ANX). Antibody titers were measured before and after pregravid preparation.Results. After PР, anti-β2-GР1 titers decreased by 66.6 % (p = 0.00001) in main group. In patients who underwent standard therapy without PР, no significant changes in circulation level of anti-β2-GР1 were noted. LA frequency in main and comparison group decreased by 57.3 % (p = 0.042) and 10.9 % (p = 0.69), respectively.Conclusion. The frequency of detecting elevated AРA levels in women after a course of efferent therapy decreased significantly, whereas standard therapy showed no such effects. PР as part of complex therapy is more appropriate for achieving maximum effect. |
| format | Article |
| id | doaj-art-47b98c9cbf194f3abf332dbd6d71a3f6 |
| institution | DOAJ |
| issn | 2313-7347 2500-3194 |
| language | Russian |
| publishDate | 2025-03-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Акушерство, гинекология и репродукция |
| spelling | doaj-art-47b98c9cbf194f3abf332dbd6d71a3f62025-08-20T02:53:58ZrusIRBIS LLCАкушерство, гинекология и репродукция2313-73472500-31942025-03-01191475810.17749/2313-7347/ob.gyn.rep.2025.584949Plasmapheresis for lowering the risks of placenta-associated complications in antiphospholipid syndromeN. F. Kuneshko0V. V. Kim1E. M. Lyadnova2A. R. Metkina3M. N. Velieva4A. V. Lazarchuk5V. O. Bitsadze6M. V. Tretyakova7D. V. Blinov8Odintsovo Regional HospitalRussian University of Medicine, Ministry of Health of the Russian FederationSechenov UniversitySechenov UniversitySechenov UniversitySechenov UniversitySechenov UniversitySechenov UniversityInstitute for Preventive and Social Medicine; Moscow Haass Medical – Social Institute; Federal Scientific and Clinical Center for Medical Rehabilitation and Balneology, Federal Medical-Biological AgencyAim: to study plasmapheresis (PP) effect on antiphospholipid syndrome (APS) treatment during preconception preparation and pregnancy.Materials and Methods. A single-center, prospective, randomized, uncontrolled study was conducted. A total of 137 women aged 22 to 32 years diagnosed with APS-related habitual miscarriage were examined. The patients were stratified as follows: main group consisted of 73 patients underwent a PF course (7 procedures at preconception preparation stage); comparison group – 64 patients not underwent efferent therapy. Antiphospholipid antibodies (APA) circulation was determined by solid-phase immunofluorescence. PР was performed using an intermittent technique. The laboratory study included assessing titers of lupus anticoagulant (LA), anti-cardiolipin antibodies (aCL), anti-β2-glycoprotein 1 antibodies (anti-β2-GP1) and anti-annexin V antibodies (anti-ANX). Antibody titers were measured before and after pregravid preparation.Results. After PР, anti-β2-GР1 titers decreased by 66.6 % (p = 0.00001) in main group. In patients who underwent standard therapy without PР, no significant changes in circulation level of anti-β2-GР1 were noted. LA frequency in main and comparison group decreased by 57.3 % (p = 0.042) and 10.9 % (p = 0.69), respectively.Conclusion. The frequency of detecting elevated AРA levels in women after a course of efferent therapy decreased significantly, whereas standard therapy showed no such effects. PР as part of complex therapy is more appropriate for achieving maximum effect.https://www.gynecology.su/jour/article/view/2346obstetric antiphospholipid syndromeapsplasmapheresispрlupus anticoagulantlaanti-cardiolipin antibodiesaclanti-β2-glycoprotein 1 antibodiesanti-β2-gр1anti-annexin v antibodiesanti-anxplacenta-associated complications |
| spellingShingle | N. F. Kuneshko V. V. Kim E. M. Lyadnova A. R. Metkina M. N. Velieva A. V. Lazarchuk V. O. Bitsadze M. V. Tretyakova D. V. Blinov Plasmapheresis for lowering the risks of placenta-associated complications in antiphospholipid syndrome Акушерство, гинекология и репродукция obstetric antiphospholipid syndrome aps plasmapheresis pр lupus anticoagulant la anti-cardiolipin antibodies acl anti-β2-glycoprotein 1 antibodies anti-β2-gр1 anti-annexin v antibodies anti-anx placenta-associated complications |
| title | Plasmapheresis for lowering the risks of placenta-associated complications in antiphospholipid syndrome |
| title_full | Plasmapheresis for lowering the risks of placenta-associated complications in antiphospholipid syndrome |
| title_fullStr | Plasmapheresis for lowering the risks of placenta-associated complications in antiphospholipid syndrome |
| title_full_unstemmed | Plasmapheresis for lowering the risks of placenta-associated complications in antiphospholipid syndrome |
| title_short | Plasmapheresis for lowering the risks of placenta-associated complications in antiphospholipid syndrome |
| title_sort | plasmapheresis for lowering the risks of placenta associated complications in antiphospholipid syndrome |
| topic | obstetric antiphospholipid syndrome aps plasmapheresis pр lupus anticoagulant la anti-cardiolipin antibodies acl anti-β2-glycoprotein 1 antibodies anti-β2-gр1 anti-annexin v antibodies anti-anx placenta-associated complications |
| url | https://www.gynecology.su/jour/article/view/2346 |
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