Fabrication of Gliadin–Carboxymethyl Chitosan Composite Nanoparticles to Improve the Stability and Antioxidant Activity of Curcumin
The antisolvent precipitation method was employed to synthesize curcumin-loaded gliadin–carboxymethyl chitosan (CMCS) composite nanoparticles (GCC NPs). When the gliadin/CMCS weight ratio was 2:1, the GCC NPs with an ideal negative charge (−27.57 ± 1.07 mV) and the minimum particle size (184.13 ± 5....
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2025-05-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/30/11/2414 |
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| author | Xinyue Zhang Mengdie Mo Haiqi Yu Hua Yang Xu Liu Yaping Xu Xiaohui Zheng Jie Wei Fei Yu Xiaodong Chen |
| author_facet | Xinyue Zhang Mengdie Mo Haiqi Yu Hua Yang Xu Liu Yaping Xu Xiaohui Zheng Jie Wei Fei Yu Xiaodong Chen |
| author_sort | Xinyue Zhang |
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| description | The antisolvent precipitation method was employed to synthesize curcumin-loaded gliadin–carboxymethyl chitosan (CMCS) composite nanoparticles (GCC NPs). When the gliadin/CMCS weight ratio was 2:1, the GCC NPs with an ideal negative charge (−27.57 ± 1.07 mV) and the minimum particle size (184.13 ± 5.49 nm) were obtained. With the addition of CMCS, the encapsulation efficiency (EE) of Cur was markedly improved from 77.46 ± 1.54% to 93.88 ± 1.31%. Under various pH values and salt concentrations, the GCC NPs displayed excellent colloidal stability. Specifically, after encapsulation within the GCC NPs, the antioxidant activity of Cur was markedly improved. In ABTS and DPPH assays, the SC<sub data-eusoft-scrollable-element="1">50</sub> values of the GCC NPs were 4.98 ± 0.07 µg/mL and 9.86 ± 0.29 µg/mL, respectively. In summary, the GCC NPs would be an effective platform for the delivery of Cur in food and pharmaceutical preparations. |
| format | Article |
| id | doaj-art-47b0da751c174d44b7a534a63690cb10 |
| institution | OA Journals |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-47b0da751c174d44b7a534a63690cb102025-08-20T02:23:08ZengMDPI AGMolecules1420-30492025-05-013011241410.3390/molecules30112414Fabrication of Gliadin–Carboxymethyl Chitosan Composite Nanoparticles to Improve the Stability and Antioxidant Activity of CurcuminXinyue Zhang0Mengdie Mo1Haiqi Yu2Hua Yang3Xu Liu4Yaping Xu5Xiaohui Zheng6Jie Wei7Fei Yu8Xiaodong Chen9Medical College, Guangxi University, Nanning 530004, ChinaMedical College, Guangxi University, Nanning 530004, ChinaMedical College, Guangxi University, Nanning 530004, ChinaMedical College, Guangxi University, Nanning 530004, ChinaMedical College, Guangxi University, Nanning 530004, ChinaKey Laboratory of Functional and Clinical Translational Medicine, Xiamen Medical College, Fujian Provincial University, Xiamen 361023, ChinaKey Laboratory of Functional and Clinical Translational Medicine, Xiamen Medical College, Fujian Provincial University, Xiamen 361023, ChinaCollege of Agriculture, Guangxi University, Nanning 530004, ChinaMedical College, Guangxi University, Nanning 530004, ChinaSuzhou Key Lab of Green Chemical Engineering, School of Chemical and Environmental Engineering, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, ChinaThe antisolvent precipitation method was employed to synthesize curcumin-loaded gliadin–carboxymethyl chitosan (CMCS) composite nanoparticles (GCC NPs). When the gliadin/CMCS weight ratio was 2:1, the GCC NPs with an ideal negative charge (−27.57 ± 1.07 mV) and the minimum particle size (184.13 ± 5.49 nm) were obtained. With the addition of CMCS, the encapsulation efficiency (EE) of Cur was markedly improved from 77.46 ± 1.54% to 93.88 ± 1.31%. Under various pH values and salt concentrations, the GCC NPs displayed excellent colloidal stability. Specifically, after encapsulation within the GCC NPs, the antioxidant activity of Cur was markedly improved. In ABTS and DPPH assays, the SC<sub data-eusoft-scrollable-element="1">50</sub> values of the GCC NPs were 4.98 ± 0.07 µg/mL and 9.86 ± 0.29 µg/mL, respectively. In summary, the GCC NPs would be an effective platform for the delivery of Cur in food and pharmaceutical preparations.https://www.mdpi.com/1420-3049/30/11/2414gliadincurcumincarboxymethyl chitosannanoparticlesantioxidant activityfood |
| spellingShingle | Xinyue Zhang Mengdie Mo Haiqi Yu Hua Yang Xu Liu Yaping Xu Xiaohui Zheng Jie Wei Fei Yu Xiaodong Chen Fabrication of Gliadin–Carboxymethyl Chitosan Composite Nanoparticles to Improve the Stability and Antioxidant Activity of Curcumin Molecules gliadin curcumin carboxymethyl chitosan nanoparticles antioxidant activity food |
| title | Fabrication of Gliadin–Carboxymethyl Chitosan Composite Nanoparticles to Improve the Stability and Antioxidant Activity of Curcumin |
| title_full | Fabrication of Gliadin–Carboxymethyl Chitosan Composite Nanoparticles to Improve the Stability and Antioxidant Activity of Curcumin |
| title_fullStr | Fabrication of Gliadin–Carboxymethyl Chitosan Composite Nanoparticles to Improve the Stability and Antioxidant Activity of Curcumin |
| title_full_unstemmed | Fabrication of Gliadin–Carboxymethyl Chitosan Composite Nanoparticles to Improve the Stability and Antioxidant Activity of Curcumin |
| title_short | Fabrication of Gliadin–Carboxymethyl Chitosan Composite Nanoparticles to Improve the Stability and Antioxidant Activity of Curcumin |
| title_sort | fabrication of gliadin carboxymethyl chitosan composite nanoparticles to improve the stability and antioxidant activity of curcumin |
| topic | gliadin curcumin carboxymethyl chitosan nanoparticles antioxidant activity food |
| url | https://www.mdpi.com/1420-3049/30/11/2414 |
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