Clinical stabilization of a highly refractory acute myeloid leukaemia under individualized treatment with immune response modifying drugs by in vivo generation of dendritic cells of leukaemic origin (DCleu) and modulation of effector cells and immune escape mechanisms

Clinical stabilization of a highly refractory acute myeloid leukaemia under individualized treatment with immune response modifying drugs by in vivo generation of dendritic cells of leukaemic origin (DCleu) and modulation of effector cells and immune escape mechanisms

Abstract The conversion of leukemic blasts into antigen-presenting dendritic cells of leukemic origin (DCleu) by GM-CSF and PGE1 has demonstrated preclinical efficacy in eliciting leukaemia-specific immune responses, offering a promising immunotherapeutic strategy for relapsed/refractory AML. We rep...

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Main Authors: Giuliano Filippini Velázquez, Philipp Anand, Joudi Abdulmajid, Xiaojia Feng, Jan Frederic Weller, Klaus Hirschbühl, Helga Schmetzer, Christoph Schmid
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Biomarker Research
Online Access:https://doi.org/10.1186/s40364-025-00817-8
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