Fulminant Pseudomembranous Colitis Presenting as Sigmoid Stricture and Severe Polyposis with Clinical Response to Intracolonic Vancomycin
Clostridium difficile infection (CDI) is the most common cause of antibiotic-associated diarrhea. Severe diseases carry significant morbidities such as septic shock, acute kidney injury, bowel perforation, and mortality. Immunocompromising conditions increase the risk of developing the disease but w...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2016/4609824 |
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| _version_ | 1832545502753718272 |
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| author | Sai Wah Cheung Kin Kong Li |
| author_facet | Sai Wah Cheung Kin Kong Li |
| author_sort | Sai Wah Cheung |
| collection | DOAJ |
| description | Clostridium difficile infection (CDI) is the most common cause of antibiotic-associated diarrhea. Severe diseases carry significant morbidities such as septic shock, acute kidney injury, bowel perforation, and mortality. Immunocompromising conditions increase the risk of developing the disease but whether these individuals suffer a more fulminant course or warrant a more potent first-line treatment is still controversial issue. Hereby we report a case of a cirrhotic patient with life-threatening pseudomembranous colitis complicated by colonic stricture, initially refractory to standard treatment but with subsequent improvement on intracolonic vancomycin. |
| format | Article |
| id | doaj-art-47afc402b58340f98d88ad7bcb76622b |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-47afc402b58340f98d88ad7bcb76622b2025-02-03T07:25:39ZengWileyCase Reports in Medicine1687-96271687-96352016-01-01201610.1155/2016/46098244609824Fulminant Pseudomembranous Colitis Presenting as Sigmoid Stricture and Severe Polyposis with Clinical Response to Intracolonic VancomycinSai Wah Cheung0Kin Kong Li1Division of Gastroenterology and Hepatology, Department of Medicine and Geriatrics, Tuen Mun Hospital, Tsing Chung Koon Road, Tuen Mun, New Territories, Hong KongDivision of Gastroenterology and Hepatology, Department of Medicine and Geriatrics, Tuen Mun Hospital, Tsing Chung Koon Road, Tuen Mun, New Territories, Hong KongClostridium difficile infection (CDI) is the most common cause of antibiotic-associated diarrhea. Severe diseases carry significant morbidities such as septic shock, acute kidney injury, bowel perforation, and mortality. Immunocompromising conditions increase the risk of developing the disease but whether these individuals suffer a more fulminant course or warrant a more potent first-line treatment is still controversial issue. Hereby we report a case of a cirrhotic patient with life-threatening pseudomembranous colitis complicated by colonic stricture, initially refractory to standard treatment but with subsequent improvement on intracolonic vancomycin.http://dx.doi.org/10.1155/2016/4609824 |
| spellingShingle | Sai Wah Cheung Kin Kong Li Fulminant Pseudomembranous Colitis Presenting as Sigmoid Stricture and Severe Polyposis with Clinical Response to Intracolonic Vancomycin Case Reports in Medicine |
| title | Fulminant Pseudomembranous Colitis Presenting as Sigmoid Stricture and Severe Polyposis with Clinical Response to Intracolonic Vancomycin |
| title_full | Fulminant Pseudomembranous Colitis Presenting as Sigmoid Stricture and Severe Polyposis with Clinical Response to Intracolonic Vancomycin |
| title_fullStr | Fulminant Pseudomembranous Colitis Presenting as Sigmoid Stricture and Severe Polyposis with Clinical Response to Intracolonic Vancomycin |
| title_full_unstemmed | Fulminant Pseudomembranous Colitis Presenting as Sigmoid Stricture and Severe Polyposis with Clinical Response to Intracolonic Vancomycin |
| title_short | Fulminant Pseudomembranous Colitis Presenting as Sigmoid Stricture and Severe Polyposis with Clinical Response to Intracolonic Vancomycin |
| title_sort | fulminant pseudomembranous colitis presenting as sigmoid stricture and severe polyposis with clinical response to intracolonic vancomycin |
| url | http://dx.doi.org/10.1155/2016/4609824 |
| work_keys_str_mv | AT saiwahcheung fulminantpseudomembranouscolitispresentingassigmoidstrictureandseverepolyposiswithclinicalresponsetointracolonicvancomycin AT kinkongli fulminantpseudomembranouscolitispresentingassigmoidstrictureandseverepolyposiswithclinicalresponsetointracolonicvancomycin |