Impact of Sleep Respiratory Disorders on Endothelial Function in Children
Obstructive sleep apnea syndrome (OSAS) in children can induce endothelial dysfunction, a well-known early marker of atherosclerosis. The study aimed to evaluate a link among endothelial function (measured by flow-mediated vasodilation (FMD)), obesity (evaluated by body mass index (BMI)), and sleep...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/719456 |
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| author | Luigia Brunetti Ruggiero Francavilla Pietro Scicchitano Valentina Tranchino Maria Loscialpo Michele Gesualdo Annapaola Zito Fara Fornarelli Marco Sassara Paola Giordano Vito Leonardo Miniello Marco Matteo Ciccone |
| author_facet | Luigia Brunetti Ruggiero Francavilla Pietro Scicchitano Valentina Tranchino Maria Loscialpo Michele Gesualdo Annapaola Zito Fara Fornarelli Marco Sassara Paola Giordano Vito Leonardo Miniello Marco Matteo Ciccone |
| author_sort | Luigia Brunetti |
| collection | DOAJ |
| description | Obstructive sleep apnea syndrome (OSAS) in children can induce endothelial dysfunction, a well-known early marker of atherosclerosis. The study aimed to evaluate a link among endothelial function (measured by flow-mediated vasodilation (FMD)), obesity (evaluated by body mass index (BMI)), and sleep disordered breathing (SDB), assessed with apnoea/hypopnoea index (AHI), in a paediatric population. We demonstrated that our little OSAS patients showed an impaired endothelial function as compared to controls. In particular, the higher the AHI, the worst the FMD values and thus the endothelial function. Although the population sample is small, this study demonstrated that OSAS could impair endothelial function and worsen cardiovascular risk profile since childhood. |
| format | Article |
| id | doaj-art-47ae648b01084f178b2a9fdfddf5a87e |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-47ae648b01084f178b2a9fdfddf5a87e2025-08-20T03:35:58ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/719456719456Impact of Sleep Respiratory Disorders on Endothelial Function in ChildrenLuigia Brunetti0Ruggiero Francavilla1Pietro Scicchitano2Valentina Tranchino3Maria Loscialpo4Michele Gesualdo5Annapaola Zito6Fara Fornarelli7Marco Sassara8Paola Giordano9Vito Leonardo Miniello10Marco Matteo Ciccone11Department of Biomedicine of the Developmental Age, Pediatric Unit “S. Maggiore”, University of Bari, Piazza G. Cesare 11, 70124 Bari, ItalyDepartment of Biomedicine of the Developmental Age, Pediatric Unit “S. Maggiore”, University of Bari, Piazza G. Cesare 11, 70124 Bari, ItalyCardiovascular Diseases Section, Department of Emergency and Organ Transplantation (DETO), University of Bari, Piazza G. Cesare 11, 70124 Bari, ItalyDepartment of Biomedicine of the Developmental Age, Pediatric Unit “S. Maggiore”, University of Bari, Piazza G. Cesare 11, 70124 Bari, ItalyDepartment of Biomedicine of the Developmental Age, Pediatric Unit “S. Maggiore”, University of Bari, Piazza G. Cesare 11, 70124 Bari, ItalyCardiovascular Diseases Section, Department of Emergency and Organ Transplantation (DETO), University of Bari, Piazza G. Cesare 11, 70124 Bari, ItalyCardiovascular Diseases Section, Department of Emergency and Organ Transplantation (DETO), University of Bari, Piazza G. Cesare 11, 70124 Bari, ItalyCardiovascular Diseases Section, Department of Emergency and Organ Transplantation (DETO), University of Bari, Piazza G. Cesare 11, 70124 Bari, ItalyCardiovascular Diseases Section, Department of Emergency and Organ Transplantation (DETO), University of Bari, Piazza G. Cesare 11, 70124 Bari, ItalyDepartment of Biomedicine of the Developmental Age, Pediatric Unit “S. Maggiore”, University of Bari, Piazza G. Cesare 11, 70124 Bari, ItalyDepartment of Biomedicine of the Developmental Age, Pediatric Unit “S. Maggiore”, University of Bari, Piazza G. Cesare 11, 70124 Bari, ItalyCardiovascular Diseases Section, Department of Emergency and Organ Transplantation (DETO), University of Bari, Piazza G. Cesare 11, 70124 Bari, ItalyObstructive sleep apnea syndrome (OSAS) in children can induce endothelial dysfunction, a well-known early marker of atherosclerosis. The study aimed to evaluate a link among endothelial function (measured by flow-mediated vasodilation (FMD)), obesity (evaluated by body mass index (BMI)), and sleep disordered breathing (SDB), assessed with apnoea/hypopnoea index (AHI), in a paediatric population. We demonstrated that our little OSAS patients showed an impaired endothelial function as compared to controls. In particular, the higher the AHI, the worst the FMD values and thus the endothelial function. Although the population sample is small, this study demonstrated that OSAS could impair endothelial function and worsen cardiovascular risk profile since childhood.http://dx.doi.org/10.1155/2013/719456 |
| spellingShingle | Luigia Brunetti Ruggiero Francavilla Pietro Scicchitano Valentina Tranchino Maria Loscialpo Michele Gesualdo Annapaola Zito Fara Fornarelli Marco Sassara Paola Giordano Vito Leonardo Miniello Marco Matteo Ciccone Impact of Sleep Respiratory Disorders on Endothelial Function in Children The Scientific World Journal |
| title | Impact of Sleep Respiratory Disorders on Endothelial Function in Children |
| title_full | Impact of Sleep Respiratory Disorders on Endothelial Function in Children |
| title_fullStr | Impact of Sleep Respiratory Disorders on Endothelial Function in Children |
| title_full_unstemmed | Impact of Sleep Respiratory Disorders on Endothelial Function in Children |
| title_short | Impact of Sleep Respiratory Disorders on Endothelial Function in Children |
| title_sort | impact of sleep respiratory disorders on endothelial function in children |
| url | http://dx.doi.org/10.1155/2013/719456 |
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