Functional assessment of the glycoproteins of a novel Hendra virus variant reveals contrasting fusogenic capacities of the receptor-binding and fusion glycoproteins

Functional assessment of the glycoproteins of a novel Hendra virus variant reveals contrasting fusogenic capacities of the receptor-binding and fusion glycoproteins

ABSTRACT A novel Hendra virus (HeV) genotype (HeV genotype 2 [HeV-g2]) was recently isolated from a deceased horse, revealing high-sequence conservation and antigenic similarities with the prototypic strain, HeV-g1. As the receptor-binding (G) and fusion (F) glycoproteins of HeV are essential for me...

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Bibliographic Details
Main Authors: Andrew Z. Ma, Yao Yu Yeo, Jean F. Lee, Colin M. Kim, Shahrzad Ezzatpour, Carolina Menchaca, Viraj Upadhye, Edward J. Annand, John-Sebastian Eden, Raina K. Plowright, Alison J. Peel, David W. Buchholz, Hector C. Aguilar
Format: Article
Language:English
Published: American Society for Microbiology 2025-02-01
Series:mBio
Subjects:
Hendra virus
receptor-binding protein
fusion protein
receptor
syncytia
Henipavirus
Online Access:https://journals.asm.org/doi/10.1128/mbio.03482-23
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