Scaling-up molecular logic to meso-systems via self-assembly
Abstract Due to the small size and biocompatibility of molecules, molecular logic-based computation is a gateway to the informational basis of life processes. Logic-based computation operates widely with discrete molecules of up to nanometric sizes. The contribution of molecule-based bulk materials...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-03-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-58379-0 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849392190599462912 |
|---|---|
| author | Ze-Qing Chen Brian Daly Chao-Yi Yao Hannah S. N. Crory Yikai Xu Ziwei Ye H. Q. Nimal Gunaratne Ayumi Kimura Seiichi Uchiyama Steven E. J. Bell Eric V. Anslyn A. Prasanna de Silva |
| author_facet | Ze-Qing Chen Brian Daly Chao-Yi Yao Hannah S. N. Crory Yikai Xu Ziwei Ye H. Q. Nimal Gunaratne Ayumi Kimura Seiichi Uchiyama Steven E. J. Bell Eric V. Anslyn A. Prasanna de Silva |
| author_sort | Ze-Qing Chen |
| collection | DOAJ |
| description | Abstract Due to the small size and biocompatibility of molecules, molecular logic-based computation is a gateway to the informational basis of life processes. Logic-based computation operates widely with discrete molecules of up to nanometric sizes. The contribution of molecule-based bulk materials of milli/centimetric size to the field has begun in more recent years. However, artificial molecule-based meso-scale systems which intrinsically perform logic operations are very rare. Here, we show that self-assembled systems consisting of cyclophane octacarboxylates and a cationic surfactant can perform such functions, where a membrane itself behaves as a Reset-Set Flip-Flop which is integrated with 7 more logic elements. Now that molecular logic-based computation operates across a wide range of contiguous size-scales, the way opens for its general use in information processing aspects of biology and synthetic biology. |
| format | Article |
| id | doaj-art-47998db514b448abb10bb627132c81c6 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-47998db514b448abb10bb627132c81c62025-08-20T03:40:50ZengNature PortfolioNature Communications2041-17232025-03-011611710.1038/s41467-025-58379-0Scaling-up molecular logic to meso-systems via self-assemblyZe-Qing Chen0Brian Daly1Chao-Yi Yao2Hannah S. N. Crory3Yikai Xu4Ziwei Ye5H. Q. Nimal Gunaratne6Ayumi Kimura7Seiichi Uchiyama8Steven E. J. Bell9Eric V. Anslyn10A. Prasanna de Silva11School of Chemistry and Chemical Engineering, Queen’s UniversitySchool of Chemistry and Chemical Engineering, Queen’s UniversitySchool of Chemistry and Chemical Engineering, Central South University, Yuelu DistrictSchool of Chemistry and Chemical Engineering, Queen’s UniversitySchool of Chemistry and Chemical Engineering, Queen’s UniversitySchool of Chemistry and Chemical Engineering, Queen’s UniversitySchool of Chemistry and Chemical Engineering, Queen’s UniversityInstitute of Engineering Innovation, The University of TokyoGraduate School of Pharmaceutical Sciences, The University of TokyoSchool of Chemistry and Chemical Engineering, Queen’s UniversitySchool of Chemistry and Chemical Engineering, Queen’s UniversitySchool of Chemistry and Chemical Engineering, Queen’s UniversityAbstract Due to the small size and biocompatibility of molecules, molecular logic-based computation is a gateway to the informational basis of life processes. Logic-based computation operates widely with discrete molecules of up to nanometric sizes. The contribution of molecule-based bulk materials of milli/centimetric size to the field has begun in more recent years. However, artificial molecule-based meso-scale systems which intrinsically perform logic operations are very rare. Here, we show that self-assembled systems consisting of cyclophane octacarboxylates and a cationic surfactant can perform such functions, where a membrane itself behaves as a Reset-Set Flip-Flop which is integrated with 7 more logic elements. Now that molecular logic-based computation operates across a wide range of contiguous size-scales, the way opens for its general use in information processing aspects of biology and synthetic biology.https://doi.org/10.1038/s41467-025-58379-0 |
| spellingShingle | Ze-Qing Chen Brian Daly Chao-Yi Yao Hannah S. N. Crory Yikai Xu Ziwei Ye H. Q. Nimal Gunaratne Ayumi Kimura Seiichi Uchiyama Steven E. J. Bell Eric V. Anslyn A. Prasanna de Silva Scaling-up molecular logic to meso-systems via self-assembly Nature Communications |
| title | Scaling-up molecular logic to meso-systems via self-assembly |
| title_full | Scaling-up molecular logic to meso-systems via self-assembly |
| title_fullStr | Scaling-up molecular logic to meso-systems via self-assembly |
| title_full_unstemmed | Scaling-up molecular logic to meso-systems via self-assembly |
| title_short | Scaling-up molecular logic to meso-systems via self-assembly |
| title_sort | scaling up molecular logic to meso systems via self assembly |
| url | https://doi.org/10.1038/s41467-025-58379-0 |
| work_keys_str_mv | AT zeqingchen scalingupmolecularlogictomesosystemsviaselfassembly AT briandaly scalingupmolecularlogictomesosystemsviaselfassembly AT chaoyiyao scalingupmolecularlogictomesosystemsviaselfassembly AT hannahsncrory scalingupmolecularlogictomesosystemsviaselfassembly AT yikaixu scalingupmolecularlogictomesosystemsviaselfassembly AT ziweiye scalingupmolecularlogictomesosystemsviaselfassembly AT hqnimalgunaratne scalingupmolecularlogictomesosystemsviaselfassembly AT ayumikimura scalingupmolecularlogictomesosystemsviaselfassembly AT seiichiuchiyama scalingupmolecularlogictomesosystemsviaselfassembly AT stevenejbell scalingupmolecularlogictomesosystemsviaselfassembly AT ericvanslyn scalingupmolecularlogictomesosystemsviaselfassembly AT aprasannadesilva scalingupmolecularlogictomesosystemsviaselfassembly |