Matrix Metalloproteinase 9 in Epilepsy: The Role of Neuroinflammation in Seizure Development
Matrix metalloproteinase 9 is a proteolytic enzyme which is recently one of the more often studied biomarkers. Its possible use as a biomarker of neuronal damage in stroke, heart diseases, tumors, multiple sclerosis, and epilepsy is being widely indicated. In epilepsy, MMP-9 is suggested to play a r...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/7369020 |
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| _version_ | 1849407730679283712 |
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| author | Elżbieta Bronisz Iwona Kurkowska-Jastrzębska |
| author_facet | Elżbieta Bronisz Iwona Kurkowska-Jastrzębska |
| author_sort | Elżbieta Bronisz |
| collection | DOAJ |
| description | Matrix metalloproteinase 9 is a proteolytic enzyme which is recently one of the more often studied biomarkers. Its possible use as a biomarker of neuronal damage in stroke, heart diseases, tumors, multiple sclerosis, and epilepsy is being widely indicated. In epilepsy, MMP-9 is suggested to play a role in epileptic focus formation and in the stimulation of seizures. The increase of MMP-9 activity in the epileptic focus was observed both in animal models and in clinical studies. MMP-9 contributes to formation of epileptic focus, for example, by remodeling of synapses. Its proteolytic action on the elements of blood-brain barrier and activation of chemotactic processes facilitates accumulation of inflammatory cells and induces seizures. Also modification of glutamatergic transmission by MMP-9 is associated with seizures. In this review we will try to recapitulate the results of previous studies about MMP-9 in terms of its association with epilepsy. We will discuss the mechanisms of its actions and present the results revealed in animal models and clinical studies. We will also provide a comparison of the results of various studies on MMP-9 levels in the context of its possible use as a biomarker of the activity of epilepsy. |
| format | Article |
| id | doaj-art-479583dc6cfb4b2d8af0490d07e19c72 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-479583dc6cfb4b2d8af0490d07e19c722025-08-20T03:35:58ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/73690207369020Matrix Metalloproteinase 9 in Epilepsy: The Role of Neuroinflammation in Seizure DevelopmentElżbieta Bronisz0Iwona Kurkowska-Jastrzębska12nd Department of Neurology, Institute of Psychiatry and Neurology, Jana III Sobieskiego 9, 02-957 Warsaw, Poland2nd Department of Neurology, Institute of Psychiatry and Neurology, Jana III Sobieskiego 9, 02-957 Warsaw, PolandMatrix metalloproteinase 9 is a proteolytic enzyme which is recently one of the more often studied biomarkers. Its possible use as a biomarker of neuronal damage in stroke, heart diseases, tumors, multiple sclerosis, and epilepsy is being widely indicated. In epilepsy, MMP-9 is suggested to play a role in epileptic focus formation and in the stimulation of seizures. The increase of MMP-9 activity in the epileptic focus was observed both in animal models and in clinical studies. MMP-9 contributes to formation of epileptic focus, for example, by remodeling of synapses. Its proteolytic action on the elements of blood-brain barrier and activation of chemotactic processes facilitates accumulation of inflammatory cells and induces seizures. Also modification of glutamatergic transmission by MMP-9 is associated with seizures. In this review we will try to recapitulate the results of previous studies about MMP-9 in terms of its association with epilepsy. We will discuss the mechanisms of its actions and present the results revealed in animal models and clinical studies. We will also provide a comparison of the results of various studies on MMP-9 levels in the context of its possible use as a biomarker of the activity of epilepsy.http://dx.doi.org/10.1155/2016/7369020 |
| spellingShingle | Elżbieta Bronisz Iwona Kurkowska-Jastrzębska Matrix Metalloproteinase 9 in Epilepsy: The Role of Neuroinflammation in Seizure Development Mediators of Inflammation |
| title | Matrix Metalloproteinase 9 in Epilepsy: The Role of Neuroinflammation in Seizure Development |
| title_full | Matrix Metalloproteinase 9 in Epilepsy: The Role of Neuroinflammation in Seizure Development |
| title_fullStr | Matrix Metalloproteinase 9 in Epilepsy: The Role of Neuroinflammation in Seizure Development |
| title_full_unstemmed | Matrix Metalloproteinase 9 in Epilepsy: The Role of Neuroinflammation in Seizure Development |
| title_short | Matrix Metalloproteinase 9 in Epilepsy: The Role of Neuroinflammation in Seizure Development |
| title_sort | matrix metalloproteinase 9 in epilepsy the role of neuroinflammation in seizure development |
| url | http://dx.doi.org/10.1155/2016/7369020 |
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